We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Hepatic multi-level responses to polyethylene microplastics in Lateolabrax maculatus: Insights from transcriptomics, antioxidant enzyme activity, and histopathology
ClearThe effects of exposure to microplastics on grass carp (Ctenopharyngodon idella) at the physiological, biochemical, and transcriptomic levels
Researchers exposed grass carp to microplastics at two concentrations for 21 days and observed liver damage, inhibited growth, and increased oxidative stress. Transcriptome analysis revealed over 1,500 differentially expressed genes related to immune response, metabolism, and cellular stress pathways. The study suggests that microplastic exposure can trigger broad physiological and molecular disruptions in freshwater fish.
Exploring the detrimental effects of microplastics on Asian seabass (Lates calcarifer) fingerlings survival and health
Researchers exposed Asian seabass fingerlings to different concentrations of polyethylene microplastics in their diet and observed significant increases in mortality. Tissue analysis revealed serious liver damage including hepatocyte degeneration and inflammation in fish fed microplastic-contaminated diets. The study provides evidence that dietary microplastic exposure poses a direct threat to the survival and health of farmed fish species.
Dietary administration of PVC and PE microplastics produces histological damage, oxidative stress and immunoregulation in European sea bass (Dicentrarchus labrax L.)
Researchers fed European sea bass diets containing PVC and polyethylene microplastics for three weeks and examined the effects on their organs and immune systems. They found significant tissue damage in the liver and intestine, along with signs of oxidative stress and altered immune function. The study suggests that even short-to-medium-term microplastic ingestion can compromise fish health, with longer exposures potentially leading to irreversible organ damage.
Comprehensive understanding the impacts of dietary exposure to polyethylene microplastics on genetically improved farmed tilapia (Oreochromis niloticus): tracking from growth, microbiota, metabolism to gene expressions
Researchers investigated the impacts of dietary polyethylene microplastics on genetically improved farmed tilapia over nine weeks, tracking effects on growth, gut microbiota, liver metabolism, and gene expression. The study found that microplastic exposure altered gut microbial communities, disrupted liver metabolic processes, and affected gene expression in brain and liver tissues. The findings suggest that microplastic contamination in fish feed and aquatic environments poses risks to farmed fish health.
Hazards of microplastics exposure to liver function in fishes: A systematic review and meta-analysis
This meta-analysis found that microplastic exposure significantly impairs fish liver function, elevating key liver enzymes (AST, ALT, ALP, LDH) and triggering oxidative stress markers in liver tissue. The toxicological mechanisms include inflammation, apoptosis, and metabolic disruption, raising concerns about the health of fish populations in microplastic-contaminated waters and the safety of fish as a human food source.
Toxic effects of polyethylene microplastics on transcriptional changes, biochemical response, and oxidative stress in common carp (Cyprinus carpio)
Researchers exposed common carp to varying concentrations of polyethylene microplastics and assessed biochemical, oxidative, and gene expression changes. The study found that microplastic exposure caused significant oxidative stress, altered liver enzyme activity, and modified the expression of stress-related genes in a dose-dependent manner.
Lipid Metabolism and Oxidative Stress Altered in Crucian Carp (Carassius auratus) Following Exposure to Microplastics Under Laboratory and Field Conditions
Researchers used high-throughput sequencing to assess the impact of microplastics on crucian carp under both field and laboratory conditions. After four weeks of in-situ exposure, intestinal microplastic levels slightly increased, and transcriptome analysis revealed over 3,000 differentially expressed genes in the liver, with notable enrichment in pathways related to lipid metabolism and oxidative stress.
Long-term exposure to virgin and seawater exposed microplastic enriched-diet causes liver oxidative stress and inflammation in gilthead seabream Sparus aurata, Linnaeus 1758
Researchers fed gilthead seabream fish a diet containing low-density polyethylene microplastics for 90 days to study long-term effects on liver health. The study found progressive increases in oxidative stress and inflammation markers in the liver, with seawater-exposed microplastics causing more damage than pristine ones, likely due to pollutants absorbed from the ocean. Encouragingly, these harmful effects were reversed after 30 days of feeding the fish a clean diet.
Effects of Polystyrene Microplastic Exposure on Liver Cell Damage, Oxidative Stress, and Gene Expression in Juvenile Crucian Carp (Carassius auratus)
Researchers exposed young crucian carp to polystyrene microplastics at different concentrations and found dose-dependent liver damage, with higher concentrations causing more severe tissue injury and weaker antioxidant defenses. The microplastics disrupted genes involved in detoxification and stress response in liver cells. Since crucian carp is a commonly consumed freshwater fish, these findings raise questions about whether microplastic-contaminated fish could affect the health of people who eat them.
Subchronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)
Gilthead seabream fed polystyrene microplastics for 21 days developed signs of liver damage including fat buildup, inflammation, and oxidative stress -- changes similar to early-stage fatty liver disease. Since fish liver responds to microplastics in ways comparable to mammalian livers, these findings raise concerns about what chronic microplastic exposure might do to liver health in humans and other animals.
Polystyrene nanospheres-induced hepatotoxicity in swamp eel (Monopterus albus): From biochemical, pathological and transcriptomic perspectives
Researchers exposed swamp eels to polystyrene nanoplastics for 28 days and found significant liver damage including oxidative stress, tissue abnormalities, and disrupted gene expression related to immune response and metabolism. Higher concentrations caused more severe liver injury, with changes detectable at both the biochemical and genetic levels. This study adds evidence that nanoplastic exposure can harm liver function in freshwater species important to aquaculture and local food supplies.
Impact of microplastics exposure on liver health: A comprehensive meta-analysis
This meta-analysis of 70 studies across mice, fish, crabs, and shrimp found that microplastic exposure significantly increases liver enzymes (ALT, AST), oxidative stress marker MDA, and pro-inflammatory cytokines (IL-6, TNF-alpha), while reducing protective antioxidant enzymes (SOD, CAT, GSH, GPx). The findings demonstrate that microplastics disrupt liver function through oxidative stress and inflammation across multiple animal species.
Assessment of microplastic-contaminated liver through gene expression profiling of four commercial fish species in the Lagos Lagoon, Nigeria
Researchers analyzed the livers of four commercial fish species from the Lagos Lagoon in Nigeria and found microplastic contamination in all of them. Gene expression analysis revealed that the microplastic accumulation triggered changes in genes related to stress response and immune function. The study raises concerns about potential health risks for people who regularly consume fish from polluted urban waterways.
PET microplastics alter the transcriptome profile and oxidative stress markers in the liver of immature piglets: an in vivo study
Researchers fed immature piglets PET microplastics for four weeks and examined the effects on their livers. They found that microplastic exposure altered gene expression patterns related to metabolism and immune response, and increased markers of oxidative stress in the liver. The study suggests that even relatively short-term microplastic ingestion may disrupt liver function at the molecular level.
Biochemical, Genotoxic and Histological Implications of Polypropylene Microplastics on Freshwater Fish Oreochromis mossambicus: An Aquatic Eco-Toxicological Assessment
Researchers fed polypropylene microplastics to freshwater tilapia and found they caused oxidative stress, DNA damage, and liver tissue deterioration, with more severe effects after 14 days compared to acute 96-hour exposure. The microplastics disrupted antioxidant enzyme systems and neurotransmitter activity in the fish. The study demonstrates that prolonged microplastic ingestion poses a significant ecological threat to freshwater fish species.
[Effects of Microplastic Exposure on Crucian Growth, Liver Damage, and Gut Microbiome Composition].
Researchers exposed crucian carp to varying concentrations of polyethylene microplastics in feed for 30 days and found that low-concentration exposure increased body weight while higher concentrations caused liver damage and altered gut microbiome composition, suggesting dose-dependent effects.
Assessment of the effect of long-term exposure to microplastics and depuration period in Sparus aurata Linnaeus, 1758: Liver and blood biomarkers
Researchers assessed the effects of 90-day microplastic exposure followed by a 30-day recovery period on gilthead sea bream (Sparus aurata). The study found that long-term ingestion of low-density polyethylene microplastics induced oxidative stress and inflammatory responses in the liver and blood, and that some biomarkers did not fully recover during the depuration period, suggesting persistent biological effects.
Enrichment of polystyrene microplastics induces histological damage, oxidative stress, Keap1-Nrf2 signaling pathway-related gene expression in loach juveniles (Paramisgurnus dabryanus)
Researchers studied how polystyrene microplastics accumulate in loach juveniles raised in ponds lined with plastic film, finding dose-dependent enrichment in the fish. The study found that microplastic exposure caused liver tissue damage, disrupted antioxidant enzyme activity, and altered the expression of genes involved in oxidative stress defense pathways.
Scruitinizing the Effects of Microplastic (Polyethylene) on Minerals and Liver Enzyme Profile Of Common Carp (Cyprinus carpio)
Researchers exposed common carp to polyethylene microplastics at three concentrations over 7 and 14 days and measured changes in blood minerals and liver enzymes. They found dose- and time-dependent increases in liver damage markers and significant ionic imbalances, including consistent drops in potassium levels. The study suggests that even short-term microplastic exposure can disrupt fish liver function and the ability to maintain proper electrolyte balance.
Nanoplastic Exposure at Environmental Concentrations Disrupts Hepatic Lipid Metabolism through Oxidative Stress Induction and Endoplasmic Reticulum Homeostasis Perturbation
A study in fish found that nanoplastics at environmentally realistic concentrations accumulated in the liver and disrupted fat metabolism, causing a condition similar to fatty liver disease. Smaller nanoplastics (100 nanometers) caused more severe damage than larger microplastics by disrupting protein processing in cells and triggering oxidative stress. These findings raise concerns that nanoplastics in the environment could affect liver health in fish and potentially in humans who consume contaminated seafood.
Long-term exposure to microplastics induces oxidative stress and a pro-inflammatory response in the gut of Sparus aurata Linnaeus, 1758
Researchers fed gilthead seabream a diet containing low-density polyethylene microplastics for 90 days and found progressive increases in oxidative stress biomarkers, inflammatory enzyme activity, and tissue damage in the gut. After a 30-day depuration period, most biomarker values returned toward normal levels, indicating some recovery capacity. The study demonstrates that long-term microplastic ingestion can induce sustained oxidative stress and inflammation in fish intestines.
Bioaccumulation of chemical pollutants from environmental microplastics in European sea bass
Researchers designed a feeding experiment to determine whether chemical contaminants from environmental microplastics undergo trophic transfer to the liver of European sea bass (Dicentrarchus labrax), testing two feeding treatments with realistic microplastic concentrations to evaluate bioaccumulation risk.
Intestinal alterations in European sea bass Dicentrarchus labrax (Linnaeus, 1758) exposed to microplastics: Preliminary results
Researchers fed European sea bass diets containing virgin and pollutant-contaminated PVC microplastic pellets for 90 days and examined the effects on their intestines. They found moderate tissue damage and increased mucus cell activity in fish exposed to both types of microplastics, with pollutant-laden particles causing the most pronounced changes. The study provides early evidence that chronic microplastic ingestion can alter gut health in commercially important fish species.
Microplastic Presence in the Digestive Tract of Pearly Razorfish Xyrichtys novacula Causes Oxidative Stress in Liver Tissue
Microplastics were found in 89% of pearly razorfish (Xyrichtys novacula) specimens from the Balearic Islands, with fish carrying more than 4 MPs showing elevated activities of glutathione peroxidase, glutathione reductase, and glutathione S-transferase in liver tissue, indicating oxidative stress and detoxification responses.