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61,005 resultsShowing papers similar to Direct Quantification of Nanoplastics Neurotoxicity by Single‐Vesicle Electrochemistry
ClearDirect Quantification of Nanoplastics Neurotoxicity by Single‐Vesicle Electrochemistry
Using single-vesicle electrochemistry, this study provides the first direct measurement of how nanoplastics disrupt neurotransmitter release at the level of individual nerve cells. Polystyrene nanoplastics taken up by neurons disrupted the cellular machinery controlling how vesicles fuse and release catecholamines (like dopamine and norepinephrine), reducing both the amount of neurotransmitter released and the frequency of release events. These findings are concerning because they suggest nanoplastic exposure could interfere with normal brain signaling at concentrations that don't immediately kill cells.
Exposure to Nanoplastics Disrupts Neurotransmitter Release in Rat Hippocampal Neurons
Researchers exposed rat hippocampal neurons to polystyrene nanoplastics and measured neurotransmitter release using electrophysiology. Nanoplastic exposure disrupted synaptic transmission by impairing calcium-dependent neurotransmitter release at hippocampal synapses, providing direct evidence of nanoplastic interference with the neural signaling machinery involved in memory and cognition.
The Effects of Nanoplastics on the Dopamine System of Cerebrocortical Neurons
Researchers studied how nanoplastics affect the dopamine system in brain neurons grown in the lab. They found that nanoplastics accumulated inside neurons in a dose-dependent manner and altered the levels of proteins involved in dopamine signaling. These results suggest that nanoplastic exposure could potentially interfere with brain chemistry, though more research is needed to understand what this means for human health.
Miniature Electrochemical Sensing Accelerates Detection of Toxic Responses Induced by Nanoplastics
This perspective article discusses how miniature electrochemical sensors can accelerate the detection of toxic responses caused by nanoplastics in living organisms. The authors highlight that conventional methods struggle to monitor the chronic, low-level toxicity that nanoplastics cause over time. They advocate for multiplexed electrochemical techniques that can provide real-time, sensitive monitoring of how organisms respond to long-term nanoplastic exposure.
Electrochemical sensing for real-time monitoring of nanoplastics – Induced toxicity: Dynamic measurements at the exposure-organism interface
This perspective paper explores how electrochemical sensors could be used to monitor the toxic effects of nanoplastics on living organisms in real time, rather than only measuring outcomes after exposure ends. Researchers outline how these sensors could track dynamic biological responses at the interface where nanoplastics first contact cells and tissues. The approach could transform how scientists study nanoplastic toxicity by capturing the full timeline of biological changes as they happen.
Alleviation of neurotoxicity induced by polystyrene nanoplastics by increased exocytosis from neurons
Researchers investigated how polystyrene nanoplastics accumulate in neurons and cause toxic effects on brain cells. They found that inhibiting a specific protein involved in transporting particles within cells promoted the export of nanoplastics from neurons, reducing their harmful effects. The study suggests that enhancing the cell's natural ability to expel nanoplastics could be a potential strategy for alleviating their neurotoxic impact.
Micro-nanoplastics in the central nervous system: Evidence, mechanisms and perspectives
This review examines evidence that micro- and nanoplastics can cross the blood-brain barrier and cause neurotoxicity through oxidative stress, neuroinflammation, and disruption of neurotransmitter signaling. While clinical studies have confirmed the presence of plastic particles in human brain tissue and cerebrospinal fluid, the authors note that methodological limitations and inconsistent quality controls currently prevent establishing a definitive causal link to neurological conditions.
Recent progress and future directions of the research on nanoplastic-induced neurotoxicity
This review summarizes current research on how nanoplastics cause damage to the nervous system, covering studies in cell cultures, zebrafish, mice, and other models. Nanoplastics can cross the blood-brain barrier, trigger oxidative stress and inflammation in brain tissue, and disrupt nerve cell function. The authors highlight that understanding these mechanisms is crucial for assessing the long-term neurological risks of human exposure to nanoplastics through food, water, and air.
Neurotoxicityof Micro- and Nanoplastics: A ComprehensiveReview of Central Nervous System Impacts
This comprehensive review examines neurotoxicity of micro- and nanoplastics, synthesizing evidence that MNP exposure disrupts neural signaling, promotes neuroinflammation, crosses the blood-brain barrier, and may contribute to neurodegenerative and neurodevelopmental disorders.
The plastic brain: neurotoxicity of micro- and nanoplastics
This review examines the emerging evidence that micro- and nanoplastics can reach the brain in both aquatic animals and mammals, potentially causing neurotoxic effects. Researchers found that exposure to these particles induces oxidative stress, inhibits key enzymes involved in nerve signaling, and alters neurotransmitter levels, which may contribute to behavioral changes. The study highlights that systematic research comparing different particle types, sizes, and exposure conditions is urgently needed to understand the neurological risks.
Neurotoxicity of nanoplastics: A review
This review examines the growing body of evidence on how nanoplastics may affect the nervous system. Researchers summarized findings showing that nanoplastics can cross biological barriers, accumulate in brain tissue, and trigger oxidative stress and inflammation in nerve cells. The evidence indicates that nanoplastic exposure may contribute to neurotoxic effects, though more research is needed to fully understand the risks to human brain health.
Crossing barriers – tracking micro- and nanoplastic pathways into the human brain
Researchers tracked potential pathways by which micro- and nanoplastics may enter the human brain, examining both in vitro cell models and post-mortem brain tissue. They found that human monocytes rapidly internalized polystyrene particles into endocytic vesicles and mitochondria, and detected plastic particles in brain tissue samples, providing evidence that nanoplastics may be capable of crossing brain barriers.
Multidimensional Unraveling Insights from an Enzyme-Nanozyme Cascade-Based Electrochemical Biosensor for Screening Microplastic Neurotoxicity
Researchers developed a rapid electrochemical biosensor that can simultaneously detect three key biomarkers in neuronal cells within minutes, enabling assessment of microplastic neurotoxicity. Using this sensor, they found that different types of microplastics affect neurons through distinct mechanisms, and that neurotoxic effects were amplified under high-glucose conditions. The study provides a new tool for quickly evaluating how microplastics impact nervous system health.
Bioeffects of Inhaled Nanoplastics on Neurons and Alteration of Animal Behaviors through Deposition in the Brain
Researchers demonstrated that nanoplastics inhaled through the nose can travel along the olfactory nerve and deposit directly in the brain, causing neuron damage and altered behavior in mice. Using a microfluidic chip to study neuron interactions, they found that smaller particles with specific surface charges caused the most severe cell damage. The study provides direct evidence that airborne nanoplastics can reach the brain through inhalation and may pose neurotoxic risks.
Nanoplastics induce SH-SY5Y cell damage through oxidative stress and disruption of amino acid metabolism
Researchers exposed human neuronal cells to five types of nanoplastics and found that polyethylene and polypropylene particles caused the most significant reductions in cell viability. The nanoplastics induced oxidative stress, disrupted mitochondrial membrane potential, and triggered cell death pathways. Transcriptomic analysis revealed that amino acid metabolism was particularly affected, suggesting a specific mechanism by which nanoplastics may damage nerve cells.
Micro- and nanoplastics in neurological dysfunction
This review examines growing evidence that micro- and nanoplastic particles can interfere with the nervous system across multiple species, including humans. Researchers found that plastic particles may disrupt cellular metabolism, affect brain development, and increase vulnerability to neurodevelopmental disorders and neurodegeneration. The authors highlight significant knowledge gaps that need to be addressed to understand the long-term neurological impacts of plastic particle exposure.
Assessing the Impact of Microplastics on Brain Chemistry: The Need for a Comprehensive Policy Framework to Mitigate Toxicity
This review examines the growing evidence that microplastics can cross biological barriers, accumulate in brain tissue, and affect neurological function. Researchers found that microplastic exposure has been linked to neurotoxicity, oxidative stress, and inflammation in the brain, with potential implications for neurotransmitter systems and cognitive function. The study calls for comprehensive regulatory measures to limit microplastic pollution and further research into the long-term neurological health effects.
A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown
This critical review of 234 studies found that micro- and nanoplastics can reach the brain via olfactory translocation or by crossing the blood-brain barrier, where they may cause neuroinflammation, oxidative damage, and behavioral changes in animal models. The evidence raises significant concerns about potential neurotoxic effects of chronic microplastic exposure in humans, though major knowledge gaps remain.
The neurotoxic threat of micro- and nanoplastics: evidence from In Vitro and In Vivo models
This systematic review examined 26 studies showing that micro- and nanoplastics can cross into the brain, damage neurons, and trigger inflammation in lab and animal models. These findings raise concerns that long-term plastic exposure could contribute to neurological problems in humans, though more research is needed.
Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
Researchers exposed zebrafish to environmentally realistic levels of polystyrene nanoplastics and found they caused both brain and reproductive damage. The nanoplastics disrupted neurotransmitter signaling and impaired the hormonal pathway connecting the brain to reproductive organs, with different effects in males and females. These findings suggest that even low-level nanoplastic exposure could affect both brain function and fertility in aquatic life that humans may consume.
Neurotoxicity induced by aged microplastics from plastic bowls: Abnormal neurotransmission in Caenorhabditis elegans
Researchers found that microplastics released from aged plastic bowls caused nerve damage in the roundworm C. elegans at environmentally realistic concentrations. The aged microplastics disrupted neurotransmitter systems including dopamine and serotonin, leading to impaired movement. This study is concerning because it shows that everyday plastic items we use for food can release microplastics that have neurotoxic effects.
Brain under siege: the role of micro and nanoplastics in neuroinflammation and oxidative stress
This review examines emerging evidence that micro- and nanoplastics can cross the blood-brain barrier and accumulate in nervous tissue, potentially triggering neuroinflammation and oxidative stress. Researchers summarized findings showing these particles may act as neurotoxicants that contribute to synaptic dysfunction and pathological changes in brain cells. The study highlights the need for further research into how chronic plastic particle exposure may affect central nervous system health over time.
Polystyrene nanoplastics target electron transport chain complexes in brain mitochondria
Researchers investigated the effects of polystyrene nanoplastics on mitochondrial function in rat brain tissue. They found that nanoplastic exposure significantly impaired the electron transport chain, specifically disrupting electron flow between respiratory complexes I-III and II-III in both synaptic and non-synaptic mitochondria. The findings reveal a potential mechanism by which nanoplastics could contribute to brain energy metabolism deficits and neurotoxicity.
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation
This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.