We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Papers
61,005 resultsShowing papers similar to Integrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos
ClearIntegrated mRNA- and miRNA-sequencing analyses unveil the underlying mechanism of tobacco pollutant-induced developmental toxicity in zebrafish embryos
Researchers exposed zebrafish embryos to cigarette smoke extract and used gene and microRNA analysis to uncover how tobacco pollutants cause developmental defects, finding disruptions in DNA repair, cell death regulation, and fat metabolism. These results help explain why prenatal tobacco exposure harms fetal development and point to specific genes that could be targeted to reduce those effects.
Transcriptional effects of polyethylene microplastics ingestion in developing zebrafish (Danio rerio)
Researchers exposed developing zebrafish to polyethylene microplastics and used transcriptomic analysis to identify changes in gene expression related to immune function, lipid metabolism, and oxidative stress. The study suggests that even at relatively low concentrations, ingested microplastics can alter key biological pathways during early fish development.
Regulation of Gene Expression in Fish
This paper is not relevant to microplastics research — it is a broad review of how environmental pollutants regulate gene expression in fish, covering heavy metals, pesticides, and endocrine disruptors.
Unravelling the developmental toxicity of heavy metals using zebrafish as a model: a narrative review
This review summarizes research on how heavy metals, including cadmium, lead, mercury, and arsenic, harm developing zebrafish embryos, which share about 80% of their genes with humans. These metals cause oxidative stress, disrupt brain development, and trigger cell death at environmentally relevant levels. The findings are relevant to microplastics research because microplastics can carry and concentrate these same heavy metals, potentially worsening their toxic effects on human development.
Single‐Cell Transcriptomic Analysis Reveals Hair Cell‐Specific Molecular Responses to Polystyrene Nanoplastics in a Zebrafish Embryo Model
Researchers exposed zebrafish embryos to polystyrene nanoplastics at environmentally relevant concentrations and used single-cell RNA sequencing to identify hair cell-specific transcriptional changes in the inner ear, finding molecular-level effects without overt developmental phenotypes.
New insight into long-term effects of phthalates microplastics in developing zebrafish: Evidence from genomic alteration and organ development
Researchers investigated the long-term developmental effects of three common plasticizers (DBP, DEP, and DEHP) leaching from microplastics on zebrafish larvae. The study found that phthalate exposure caused higher mortality, morphological abnormalities, and significant changes in genes related to cardiovascular development, tail formation, and other critical developmental pathways.
The time-dependent variations of zebrafish intestine and gill after polyethylene microplastics exposure
Researchers found that polyethylene microplastic exposure caused time-dependent changes in zebrafish intestinal and gill gene expression, with 186 differentially expressed genes in the intestine revealing molecular mechanisms of MP-induced organ damage.
Research progress of model animal zebrafish in toxicity evaluation of microplastics
This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.
Effects of Nanoplastics and Butyl Methoxydibenzoylmethane on Early Zebrafish Embryos Identified by Single-Cell RNA Sequencing
Researchers used single-cell RNA sequencing to study how polystyrene nanoplastics and the sunscreen chemical BMDBM affect early zebrafish embryo development. The study found that both pollutants targeted neural cells and disrupted brain development pathways, though combined exposure appeared to reduce some adverse effects compared to individual exposures, highlighting the complexity of nanoplastic interactions with co-occurring contaminants.
Prediction and validation of regulatory role of microRNAs in zebrafish (Danio rerio) responses to nanoparticle exposure with in silico and in vitro toxicological approaches
This thesis developed in silico and in vitro methods to predict how microRNAs regulate zebrafish responses to nanoparticle exposure, providing new tools for assessing nanoparticle toxicity. As nanoplastics are a type of nanoparticle, these methods have direct application to understanding how nanoplastics affect aquatic organisms at the molecular level.
Acute toxic effects of polyethylene microplastic on adult zebrafish
Researchers exposed adult zebrafish to polyethylene microplastics of various sizes to identify physical effects, behavioral changes, and gene expression impacts. They found that microplastic ingestion varied by particle size and that exposure altered expression of detoxification and reproduction-related genes. The study suggests that microplastic pollution at environmentally relevant concentrations could affect both the health and reproductive capacity of fish.
Effects of microplastics on the toxicity of co-existing pollutants to fish: A meta-analysis
Meta-analysis of 1,380 biological endpoints from 55 studies found that microplastics in co-existing pollutant solutions significantly increased toxicity to fish beyond what the pollutants caused alone, particularly elevating immune system damage, metabolic disruption, and oxidative stress. The effect depended on fish life stage and microplastic size, but not on pollutant or polymer type.
Surgical face masks as a source of emergent pollutants in aquatic systems: Analysis of their degradation product effects in Danio rerio through RNA-Seq.
Researchers used RNA-Seq analysis to reveal that degradation products from surgical face masks caused significant toxicogenomic effects in zebrafish, identifying these pandemic-era disposable masks as an emerging source of microplastic and chemical pollution in aquatic systems.
Toxicological impacts of nanopolystyrene on zebrafish oocyte with insight into the mechanism of action: An expression-based analysis
Researchers investigated the mechanism by which nanopolystyrene causes toxicity in zebrafish oocytes, finding it triggers oxidative stress, immune disruption, and mitochondrial dysfunction through changes in key gene expression pathways.
Polystyrene microplastics alleviate the developmental toxicity of silver nanoparticles in embryo-larval zebrafish (Danio rerio) at the transcriptomic level
In a surprising finding, researchers discovered that when zebrafish embryos were exposed to both silver nanoparticles and polystyrene microplastics together, the microplastics actually reduced the toxic effects of the silver nanoparticles. The study suggests that microplastics may interact with other pollutants in complex ways, sometimes lessening rather than amplifying their harmful impacts on developing organisms.
Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos
This review summarizes research on how micro- and nanoplastics harm embryo development using zebrafish as a model organism that shares genetic similarities with humans. Studies show these tiny plastic particles cause damage to the brain, heart, gut, and immune system of developing embryos, largely through oxidative stress and cell death pathways.
Deposition of microplastics associated with bioaccumulation of heavy metals in human lungs of smokers: Implications of adsorption and mobilization of metals via microplastics
Researchers compared lung tissue from smokers and non-smokers and found that smokers accumulated more microplastics alongside elevated levels of heavy metals in lung tissue, suggesting that tobacco smoke enhances chelation of heavy metals to airborne microplastics, increasing lung bioaccumulation.
Effects of microplastics on the accumulation and neurotoxicity of methylmercury in zebrafish larvae
Researchers found that microplastics can adsorb methylmercury and act as carriers, increasing its accumulation in zebrafish larvae and worsening neurotoxicity by disrupting locomotor activity and triggering oxidative stress.