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61,005 resultsShowing papers similar to Molecular Mechanisms of Environmental Pollutants in Human Health for Unravelling the Pathophysiology of Chronic Diseases
ClearUnravelling the signaling power of pollutants
Researchers reviewed how environmental pollutants enter the body, cross biological barriers including the blood-brain barrier, and trigger cellular damage through oxidative stress, mitochondrial dysfunction, and inflammation, emphasizing that pollutant-receptor signaling interactions may compromise drug therapies for chronic diseases.
Immune–Epigenetic Effects of Environmental Pollutants: Mechanisms, Biomarkers, and Transgenerational Impact
This review examines how environmental pollutants, including microplastics, heavy metals, and endocrine-disrupting chemicals, can alter immune function through epigenetic changes that modify gene expression without changing DNA itself. Researchers identified common molecular pathways through which these pollutants trigger inflammation and immune disruption. The study also highlights evidence that some of these epigenetic changes may be passed to future generations.
Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations
This review examined the mechanisms by which environmental xenobiotics—including heavy metals, persistent organic pollutants, pesticides, phthalates, and microplastics—contribute to cancer development, synthesizing evidence across multiple tumor types. The authors found that chronic low-dose exposures to plastic-associated chemicals are increasingly implicated in carcinogenesis via DNA damage, hormonal disruption, and epigenetic mechanisms.
Microplastics and human health: unraveling the toxicological pathways and implications for public health
This review pulls together recent research on how microplastics enter the human body and cause cellular damage through inflammation, oxidative stress, and direct cell injury. The authors highlight that microplastics can also amplify the harmful effects of other environmental pollutants they carry, creating combined health risks that are greater than either threat alone.
Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases.
This review examined how environmental toxins—including microplastics, heavy metals, air pollutants, and endocrine disruptors—contribute to cardiovascular disease through oxidative stress mechanisms. It argued that environmental toxin exposure accounts for a meaningful share of cardiovascular morbidity that traditional risk factor models fail to capture.
Facing stress and inflammation: From the cell to the planet.
This review examines stress and inflammation as interconnected biological responses at scales from the cell to the whole planet, tracing how environmental stressors including pollution drive inflammatory disease. The paper positions microplastic contamination and other anthropogenic pollutants as systemic stressors that may be contributing to rising rates of chronic inflammatory conditions.
Chronic diseases: Origin and cell mechanisms involved
This paper is not about microplastics; it is a broad review of cellular mechanisms — DNA damage, oxidative stress, inflammation — underlying chronic diseases such as cardiovascular disease, cancer, and diabetes, with no substantive focus on microplastics.
Environmental Xenobiotics and Epigenetic Modifications: Implications for Human Health and Disease
This review examines how environmental pollutants, including microplastics, can change gene activity through epigenetic modifications without altering DNA itself. These changes to how genes are turned on and off can contribute to cancer, brain diseases, and developmental problems, and may even be passed down to future generations. The research highlights that microplastics and other common pollutants could have long-lasting health effects that go beyond direct chemical toxicity.
Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases
This review explores the concept of the exposome -- the total of all environmental exposures a person encounters throughout their lifetime, including chemical pollutants, microplastics, air pollution, and stress. It highlights how these combined exposures interact to drive chronic diseases like cancer, heart disease, and diabetes, emphasizing that microplastics are one piece of a larger puzzle of environmental health threats.
Microplastics, Endocrine Disruptors, and Oxidative Stress: Mechanisms and Health Implications
This review examines how microplastics and nanoplastics trigger oxidative stress as a central mechanism of toxicity across multiple organ systems, including reproductive, cardiovascular, hepatic, and neurological tissues. The study highlights that these particles often carry endocrine-disrupting chemicals like bisphenol A and phthalates, which together generate reactive oxygen species, impair mitochondrial function, and compromise antioxidant defenses.
Elucidating the Neurotoxicopathological Impact of Micro and Nanoplastics: Mechanistic Insights Into Oxidative Stress-mediated Neurodegeneration and Implications for Public Health in a Plastic Pervasive Era
Researchers reviewed the growing evidence linking micro- and nanoplastic exposure to neurodegenerative diseases, identifying oxidative stress, neuroinflammation, DNA damage, and protein misfolding as key mechanisms of harm to the brain. The review highlights critical knowledge gaps — especially around chronic low-dose exposure — and calls for better detection tools and public health policies to address the emerging neurological threat from plastic pollution.
Environmental Pollutants and Oxidative Stress in Terrestrial and Aquatic Organisms: Examination of the Total Picture and Implications for Human Health
This comprehensive review examines how various environmental pollutants, including microplastics, toxic metals, and pesticides, induce oxidative stress in both terrestrial and aquatic organisms. The study highlights the interconnected pathways through which pollution-driven oxidative damage in wildlife may carry implications for understanding broader environmental health risks.
Molecular mechanisms underlying mitochondrial damage, endoplasmic reticulum stress, and oxidative stress induced by environmental pollutants
This review examines how environmental pollutants including microplastics, heavy metals, and pesticides damage cells by disrupting mitochondria, triggering endoplasmic reticulum stress, and generating harmful reactive oxygen species. Researchers describe the molecular signaling pathways through which these pollutants cause cell dysfunction and death. The study highlights the interconnected nature of these cellular stress responses and their relevance to understanding pollution-related health effects.
Exposure to environmental xenobiotics and lung tissue function: A comprehensive review on biological mechanisms and pathways
This comprehensive review examines how environmental pollutants including microplastics, heavy metals, and volatile organic compounds damage lung tissue through mechanisms like oxidative stress, inflammation, and disruption of cellular barriers. The study suggests these pollutants contribute to chronic respiratory diseases and highlights how they can also cause epigenetic changes that may affect future generations.
The impact of environmental microplastics as emerging carcinogens: A public health concern
This review investigated the mechanisms by which microplastics may contribute to cancer development, examining studies from 2010 to 2024. Researchers found that microplastics can induce oxidative stress, inflammation, and DNA damage through multiple pathways, and that human exposure occurs primarily through ingestion, inhalation, and dermal contact. The study suggests that microplastics represent an emerging class of environmental concern warranting further investigation into their long-term health effects.
Micro-and Nanoplastic-Induced Biochemical Toxicity: Emerging Mechanisms and Health Risks Across Biological Systems
This comprehensive review synthesizes current understanding of how micro- and nanoplastics cause biochemical toxicity across biological systems, from plants and invertebrates to vertebrates and humans. Key mechanisms include oxidative stress, membrane disruption, immune activation, genotoxicity, endocrine disruption, and microbiome perturbation, all modulated by particle size, shape, and surface chemistry. The authors highlight critical gaps in standardization, chronic low-dose effect data, and the need for translatable biomarkers for risk assessment.
Microplastic-Induced Cellular Stress: Emerging Mechanisms Linking Environmental Nanoparticles to Human Metabolic Disorders
This book reviewed emerging cellular mechanisms by which microplastics induce stress in human cells, with a focus on how environmental nanoparticles contribute to metabolic disorders. It connected microplastic exposure to oxidative stress, inflammation, and disruption of cellular homeostasis.
Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers
This review examines growing evidence that microplastics and nanoplastics may play a role in cancer development, with these particles found in human tumor tissues from the lungs, colon, stomach, breast, and other organs. The particles appear to promote cancer through chronic inflammation, oxidative stress, DNA damage, and disruption of key cancer-related signaling pathways. While direct proof of causation in humans is still lacking, the accumulating evidence from lab studies, animal experiments, and human tissue analysis suggests microplastics deserve serious attention as potential contributors to cancer risk.
Toxicity Induced by Micro-and Nanoplastics through Oxidative Stress: The Role of Co-Exposure to Other Chemical Pollutants
This review examined how micro- and nanoplastics cause oxidative stress — a form of cellular damage — in living organisms, particularly when combined with other chemical pollutants in the environment. Co-exposure to microplastics and chemicals like pesticides or heavy metals tends to be more damaging than either pollutant alone.
Cellular and Molecular Mechanisms of Micro- and Nanoplastics Driving Adverse Human Health Effects
This review examines the biological mechanisms by which micro- and nanoplastics may cause harm in humans, including oxidative stress, inflammation, disruption of protective barriers, and immune system problems. Evidence from lab and animal studies suggests these particles can affect the gut, heart, brain, and reproductive systems, though human data is still limited to detecting plastics in tissues rather than proving they cause specific diseases. The authors highlight that most studies use higher doses than people actually encounter, making it important to develop research models that better reflect real-world chronic exposure.
Emerging environmental stressors and oxidative pathways in marine organisms: Current knowledge on regulation mechanisms and functional effects
This review summarized current knowledge on how emerging environmental pollutants including microplastics, heavy metals, and other stressors trigger oxidative stress in marine organisms, examining regulatory mechanisms from pre-transcriptional to catalytic levels.
Micro- and nanoplastics: Emerging environmental threats to the Developmental Origins of Health and Disease
This review examines how micro- and nanoplastic exposure may contribute to chronic health conditions through the lens of developmental origins of health and disease. Evidence suggests that microplastics accumulate in human metabolic and reproductive tissues and may induce physiological and epigenetic changes that could potentially be inherited by future generations, though research into these mechanisms is still in early stages.
A review of environmental metabolism disrupting chemicals and effect biomarkers associating disease risks: Where exposomics meets metabolomics
This review examines how environmental chemicals, including contaminants associated with plastics, can disrupt human metabolism and contribute to conditions like obesity and diabetes. Researchers mapped the connections between chemical exposure and changes in metabolic biomarkers that signal disease risk. The study highlights the emerging field of metabolism-disrupting chemicals and the importance of understanding how everyday environmental exposures influence long-term metabolic health.
Microplastic Contamination: A Rising Environmental Crisis With Potential Oncogenic Implications
This review examines how microplastics detected in human tissues — blood, placenta, and organs — may act as vectors for carcinogens, including adsorbed heavy metals and persistent organic pollutants, and discusses emerging evidence linking MP accumulation to oncogenic processes.