Papers

61,005 results
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Article Tier 2

Effect of microplastic binding capacity on antioxidant and immune responses of Korean rockfish Sebastes schlegeli in a co-exposure environment with microplastics and Streptococcus iniae

Researchers investigated what happens when Korean rockfish are exposed to both microplastics and the fish pathogen Streptococcus iniae at the same time. They found that microplastics can bind to the bacteria and amplify harmful effects on the fish's antioxidant defenses and immune responses beyond what either stressor causes alone. The findings suggest that microplastic pollution in coastal aquaculture environments may worsen the impact of bacterial infections on fish health.

2025 Chemosphere 3 citations
Article Tier 2

The Effects of Different Concentrations of Microplastics on the Physiology and Behavior of Sebastes schlegelii

Researchers exposed juvenile black rockfish (Sebastes schlegelii) to polystyrene microplastics for 24 days, finding that concentrations of 0.1 mg/L and above caused significant antioxidant enzyme disruption, immune suppression with rising inflammatory cytokines, and reduced survival at 1 mg/L.

2025 Preprints.org
Article Tier 2

Gut microbiota related response of Oryzias melastigma to combined exposure of polystyrene microplastics and tetracycline

Researchers exposed estuarine fish to polystyrene microplastics and the antibiotic tetracycline, both alone and in combination, for four weeks. The combined exposure caused more severe disruption to gut bacteria and liver tissue than either pollutant alone, with microplastics appearing to worsen the effects of tetracycline. The study suggests that the co-occurrence of microplastics and antibiotics in coastal waters may pose greater ecological risks than either contaminant by itself.

2023 The Science of The Total Environment 18 citations
Article Tier 2

Biotransformation and oxidative stress markers in yellowfin seabream (Acanthopagrus latus): Interactive impacts of microplastics and florfenicol

Researchers studied how microplastics interact with the antibiotic florfenicol to affect detoxification enzymes and oxidative stress in yellowfin seabream. They found that combined exposure to both pollutants caused more pronounced liver damage and oxidative stress than either substance alone, and that recovery took longer. The study suggests that microplastics can worsen the toxic effects of antibiotics used in aquaculture.

2024 The Science of The Total Environment 7 citations
Article Tier 2

Impacts of polystyrene microplastics on the behavior and metabolism in a marine demersal teleost, black rockfish (Sebastes schlegelii)

Researchers exposed black rockfish to two sizes of polystyrene microplastics and measured changes in behavior, metabolism, and energy reserves. They found that larger microplastics caused more significant behavioral changes including reduced swimming speed and clustering, along with increased metabolic stress indicators. The study suggests that microplastic exposure can alter fish behavior and metabolism in ways that may compromise feeding and survival in the wild.

2019 Journal of Hazardous Materials 215 citations
Article Tier 2

Rainbow trout (Oncorhynchus mykiss) physiological response to microplastics and enrofloxacin: Novel pathways to investigate microplastic synergistic effects on pharmaceuticals

Scientists studied how microplastics interact with the antibiotic enrofloxacin in rainbow trout and found that the combination increased toxicity beyond what either pollutant caused alone. The microplastics appeared to change how the antibiotic was absorbed and processed in the fish, leading to greater liver damage and immune system disruption. Since fish are exposed to both pollutants in real waterways, this synergistic toxicity could affect seafood safety and the health of people who consume contaminated fish.

2023 Aquatic Toxicology 78 citations
Article Tier 2

Ecotoxicological assessment of microplastics and florfenicol on Acanthopagrus latus: mucus, humoral immune responses and DNA damage

Researchers exposed yellowfin seabream to microplastics and the antibiotic florfenicol, both individually and in combination, over a 10-day period. They found that microplastics elevated cholesterol, glucose, and liver enzyme levels while suppressing immune markers in both blood and skin mucus. The combined exposure to microplastics and florfenicol produced more severe and longer-lasting effects than the antibiotic alone.

2025 Ecotoxicology 1 citations
Article Tier 2

Acute co-exposure to microbeads and cadmium enhances accumulation and alters plasma biochemical markers and stress indicators in Korean rockfish, Sebastes schlegeli

Researchers found that combined acute exposure of Korean rockfish to microbeads and cadmium enhanced heavy metal accumulation in fish tissues more than cadmium alone, with microplastics facilitating metal adsorption and transport in ways that increase contaminant bioavailability.

2025 Fish Physiology and Biochemistry
Article Tier 2

Combined effects of microplastics and benzo[a]pyrene on Asian sea bass Lates calcarifer growth and expression of functional genes

Researchers exposed juvenile Asian sea bass to polyethylene microplastics and the carcinogen benzo[a]pyrene, both individually and in combination, over 56 days. They found that co-exposure caused more severe effects on growth and gene expression related to immune function and stress response than either contaminant alone. The study highlights that microplastics may worsen the toxic effects of chemical pollutants already present in marine environments.

2024 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology 7 citations
Meta Analysis Tier 1

When antibiotics encounter microplastics in aquatic environments: Interaction, combined toxicity, and risk assessments

A meta-analysis of the combined toxicity of antibiotics and microplastics in aquatic environments found significant adverse effects on algae but limited apparent effects on fish and daphnia. Microplastics alter antibiotic environmental behavior through adsorption and co-transport, and their coexistence is widespread across global aquatic study sites, though standardized risk assessment methods for combined exposure remain lacking.

2024 The Science of The Total Environment 33 citations
Article Tier 2

Antagonistic toxicity of nanoplastics and perfluorobutanoic acid to the behavior of black rockfish (Sebastes schlegelii)

Researchers studied the combined effects of polystyrene nanoplastics and the industrial chemical perfluorobutanoic acid on black rockfish behavior. While each pollutant alone caused behavioral problems like reduced swimming speed and social interaction, exposing fish to both together actually reduced the severity of behavioral disruption compared to the chemical alone. The findings reveal an unexpected antagonistic interaction, suggesting that pollutant mixtures in the ocean may not always produce additive harmful effects.

2025 Environmental Pollution 4 citations
Article Tier 2

Effect of Polypropylene Microplastic and Florfenicol Antibiotic on Some Hormonal and Haematological Biomarkers in Yellowfin Seabream (Acanthopagrus latus)

Researchers studied the combined effects of polypropylene microplastics and the antibiotic florfenicol on blood and hormone markers in yellowfin seabream. They found that exposure to both pollutants together caused more pronounced changes in cortisol, thyroid hormones, and blood cell counts than either substance alone. The study suggests that the co-occurrence of microplastics and antibiotics in marine environments may create compounding health effects in fish.

2025 AQUATIC SCIENCES AND ENGINEERING 3 citations
Article Tier 2

Combined impacts of organophosphate pesticide and polyamide microplastics on growth, hematology, and immune responses in juvenile striped catfish (Pangasianodon hypophthalmus)

Researchers exposed juvenile striped catfish to both polyamide microplastics and an organophosphate pesticide, finding that the combination caused more severe growth reduction, immune suppression, and organ damage than either pollutant alone — evidence that microplastics and pesticides can act together to amplify harm in freshwater fish.

2025 Emerging contaminants 5 citations
Article Tier 2

Interactive effects of polystyrene microplastics and roxithromycin on bioaccumulation and biochemical status in the freshwater fish red tilapia (Oreochromis niloticus)

Researchers investigated the combined effects of polystyrene microplastics and the antibiotic roxithromycin on red tilapia and found that microplastics enhanced the bioaccumulation of the drug in fish tissues. The co-exposure also produced greater biochemical disruption than either contaminant alone, suggesting microplastics may act as carriers that increase pharmaceutical uptake in freshwater fish.

2018 The Science of The Total Environment 349 citations
Article Tier 2

Accumulation and ecotoxicological effects induced by combined exposure of different sized polyethylene microplastics and oxytetracycline in zebrafish

Researchers conducted a 30-day experiment exposing zebrafish to different sized polyethylene microplastics combined with the antibiotic oxytetracycline. They found that smaller nanoplastics increased antibiotic accumulation in fish liver by up to 44.5%, and the combined exposure caused more severe liver damage than either contaminant alone, with effects worsening as particle size decreased. The study suggests that microplastics can amplify the toxicity of antibiotics in aquatic organisms through enhanced bioaccumulation.

2022 Environmental Pollution 45 citations
Article Tier 2

Potential risks of microplastics combined with superbugs: Enrichment of antibiotic resistant bacteria on the surface of microplastics in mariculture system

Microplastics in a mariculture (sea farming) system were found to selectively enrich antibiotic-resistant bacteria on their surfaces compared to surrounding water, creating hotspots of antibiotic resistance in food production environments. This dual threat - microplastics acting as both pollutants and carriers of resistant pathogens - has significant implications for seafood safety.

2019 Ecotoxicology and Environmental Safety 325 citations
Article Tier 2

Biomicroplastics and Antibiotics: A Toxic Cocktail for Fatty Liver Disease in Marine Medaka.

Marine medaka fish co-exposed to aged polylactic acid (PLA) biomicroplastics and the antibiotic sulfamethazine developed fatty liver disease more severely than with either contaminant alone, demonstrating synergistic toxicity. The study highlighted that bioplastic debris combined with antibiotics poses a serious health threat to marine organisms.

2025 Environmental science & technology
Article Tier 2

Microplastics and tetracycline affecting apoptosis, enzyme activities and metabolism processes in the Aurelia aurita polyps: insights into combined pollutant effects

Researchers studied how microplastics and the antibiotic tetracycline together affect moon jellyfish polyps, examining cell death, enzyme activity, and metabolism. They found that combined exposure triggered more severe oxidative stress and metabolic disruption than either pollutant alone. The findings suggest that the co-presence of microplastics and antibiotics in marine environments may pose compounding threats to bottom-dwelling organisms.

2025 Frontiers in Marine Science 4 citations
Article Tier 2

Impact of polypropylene microplastics and chemical pollutants on European sea bass (Dicentrarchus labrax) gut microbiota and health

Researchers investigated how polypropylene microplastics, alone and combined with chemical pollutants, affect the gut health and microbiome of European sea bass. They found that microplastic ingestion altered the gut microbial community composition and that combined exposure with pollutants amplified the harmful effects. The study suggests that microplastics may serve as carriers for toxic chemicals, compounding their impact on fish health and potentially affecting seafood safety.

2021 The Science of The Total Environment 119 citations
Article Tier 2

Nanoplastics enhance the intestinal damage and genotoxicity of sulfamethoxazole to medaka juveniles (Oryzias melastigma) in coastal environment

Scientists exposed young medaka fish to the antibiotic sulfamethoxazole and polystyrene nanoplastics, both individually and together, to study their combined effects on intestinal health. They found that co-exposure caused more severe gut damage than either pollutant alone, disrupting the gut microbiome and triggering changes in gene expression related to immune defense and DNA repair. The study suggests that nanoplastics may amplify the harmful effects of antibiotics on fish in coastal environments.

2023 The Science of The Total Environment 16 citations
Article Tier 2

Combined toxicity of polystyrene microplastics and sulfamethoxazole on zebrafish embryos

Researchers investigated the combined toxicity of polystyrene microplastics and the antibiotic sulfamethoxazole on zebrafish embryos. They found that co-exposure caused significant mortality, malformations, reduced movement, increased heartbeat rates, and endocrine disruption including elevated vitellogenin and hormone levels. While the two pollutants showed antagonistic rather than synergistic interactions, their combined effects were still substantial, highlighting the importance of studying microplastic-pollutant mixtures in aquatic environments.

2021 Environmental Science and Pollution Research 56 citations
Article Tier 2

Interactions and associated resistance development mechanisms between microplastics, antibiotics and heavy metals in the aquaculture environment

This review explores how microplastics, antibiotics, and heavy metals interact in aquaculture environments to promote antibiotic resistance. Researchers found that microplastics can serve as carriers for both antibiotics and metals, creating hotspots where bacteria are more likely to develop resistance genes. The study underscores the compounding ecological and human health risks when these three types of pollutants co-exist in fish farming settings.

2021 Reviews in Aquaculture 108 citations
Article Tier 2

Co-exposure toxicity of microplastic and sumithion in Nile tilapia – changes in growth, hematology, histopathology of internal tissues and immune-antioxidant genes expression

Researchers studied the combined effects of polyamide microplastics and the pesticide sumithion on Nile tilapia, a widely farmed fish species. They found that co-exposure reduced growth, disrupted blood parameters, caused tissue damage in gills and intestines, and altered immune and antioxidant gene expression more severely than either pollutant alone. The study highlights that microplastics and pesticides together may pose amplified threats to fish health in contaminated aquaculture environments.

2025 Journal of Hazardous Materials Advances 2 citations
Article Tier 2

Microplastics Enhance the Toxic Effects of Tetracycline on the Early Development of Zebrafish in a Dose-Dependent Manner

Researchers exposed zebrafish embryos and larvae to polyethylene microplastics combined with the antibiotic tetracycline and found that the combination enhanced toxic effects in a dose-dependent manner. The co-exposure caused increased mortality, reduced body length, cardiac abnormalities, and aberrant vascular development through mechanisms involving oxidative stress and inflammation. The findings demonstrate that microplastics can amplify the toxicity of antibiotics during critical early developmental stages in fish.

2025 Fishes 1 citations