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61,005 resultsShowing papers similar to Protective effects of Vitamin E against Zinc Oxide nanoparticles-induced histotoxicity of liver and testicular tissue, genotoxicity and biomarker stress in male albino rats
ClearEffectiveness of N-Acetylcysteine on Zinc oxide Nanoparticles-Induced Cardiotoxicity in Adult Albino Rats
Researchers exposed adult albino rats to zinc oxide nanoparticles orally and investigated whether N-acetylcysteine — a free radical scavenger — could protect against ZnO nanoparticle-induced cardiotoxicity, measuring oxidative stress markers, histopathological changes, and cardiac enzyme levels to evaluate the mechanistic basis and protective efficacy of NAC treatment.
Evaluating the Effectiveness of Vitamins E and C in Mitigating the Toxic Effects of Zinc Oxide Bulk and Nanoparticles on Fish: A Review
This paper is not relevant to microplastics — it is a review of how vitamins E and C can reduce the toxic effects of zinc oxide nanoparticles on fish in aquatic environments.
Vitamin E Mitigates Polystyrene-Nanoplastic-Induced Visual Dysfunction in Zebrafish Larvae
Researchers found that vitamin E, a common antioxidant, can protect against vision damage caused by polystyrene nanoplastics in zebrafish larvae. The nanoplastics caused eye defects and visual impairment by triggering harmful oxidative stress, but vitamin E treatment significantly reduced this damage, suggesting antioxidants might help counteract some harmful effects of nanoplastic exposure.
Modulation efficiency of clove oil nano-emulsion against genotoxic, oxidative stress, and histological injuries induced via titanium dioxide nanoparticles in mice
Researchers found that titanium dioxide nanoparticles (used widely in sunscreens and food products) caused DNA damage, oxidative stress, and organ tissue injury in mice, but that a clove oil nanoemulsion significantly reversed these harmful effects — suggesting a natural antioxidant treatment may protect against nanoparticle toxicity.
Determination of Oxidative Stress Responses Caused by Zinc Oxide Nanoparticle on Gammarus Pulex
Gammarus pulex, a freshwater invertebrate indicator species, was exposed to zinc oxide nanoparticles at 0, 10, 20, and 40 ppm for 24 and 96 hours to assess oxidative stress responses. The study measured antioxidant enzyme activities and related biomarkers, finding concentration- and time-dependent oxidative stress effects.
Protective Effects of Theaflavins and Epigallocatechin Gallate against ZnO-NP-Induced Cell Apoptosis In Vitro
Researchers evaluated whether theaflavins (TFs) and epigallocatechin gallate (EGCG) could protect rat tracheal epithelial cells against zinc oxide nanoparticle (ZnO-NP)-induced cytotoxicity, exposing cells to 100 micrograms per liter ZnO-NPs followed by varying concentrations of the tea polyphenols and measuring oxidative stress, inflammation, and apoptosis markers. Both compounds showed protective effects against ZnO-NP-induced cell damage in a dose-dependent manner.
Combined cerium and zinc oxide nanoparticles induced hepato-renal damage in rats through oxidative stress mediated inflammation
Researchers found that combined cerium and zinc oxide nanoparticles induced liver and kidney damage in rats through oxidative stress-mediated inflammation, demonstrating that co-exposure to multiple nanoparticles can produce synergistic toxic effects.
Synthesis and Characterization of Silica, Silver-Silica, and Zinc Oxide-Silica Nanoparticles for Evaluation of Blood Biochemistry, Oxidative Stress, and Hepatotoxicity in Albino Rats
Researchers synthesized silica nanoparticles combined with silver and zinc oxide and tested their effects on rat blood chemistry and liver health. The nanoparticles caused dose-dependent changes in liver enzymes and oxidative stress markers, with the silver-silica composite showing the strongest effects. This study contributes to understanding how engineered nanoparticles interact with biological systems, relevant to the broader field of particle toxicology.
Hepatoprotective Effects of Chitosan and Chitosan Nanoparticles
Researchers assessed the hepatoprotective effects of chitosan and chitosan nanoparticles against ethanol-induced liver injury in male Wistar rats, finding that both compounds administered orally at 200 mg/kg significantly reduced elevated liver enzyme levels (AST and ALT) and lipid peroxidation, with chitosan nanoparticles demonstrating superior antioxidant activity in DPPH assays compared to bulk chitosan.
Potential of Cinnamomum burmanni Leaf Extract as an Exogenous Antioxidant and Spermatoprotective for Rattus norvegicus L. Exposed to Polystyrene Nanoplastics
Researchers tested whether Cinnamomum burmanni leaf extract could protect male rat reproductive function against polystyrene nanoplastic (NP) toxicity by acting as an exogenous antioxidant. NPs increased oxidative stress and impaired sperm quality and spermatogenic cell counts, while C. burmanni extract at 200–400 mg/kg restored SOD and CAT activity, improved sperm parameters, and protected testicular morphology.
Histological, Haematological, and thyroid hormones toxicity of oral exposure to CuO/ZnO core/shell nanoparticles in female rats
Researchers assessed the in vivo toxicity of CuO/ZnO core/shell nanoparticles (30 nm) in female albino rats via 30-day oral administration at doses from 5 to 40 mg/L, finding significant alterations in white blood cells, red blood cells, hemoglobin, hematocrit, and thyroid hormone levels, indicating systemic toxicity at low doses.
Use of DNA adduct and histopathological defects as indications for bio-persistence potency of zinc oxide nanoparticles in gastropod, Monacha cartusiana (Mǜller) after short-term exposure
Researchers assessed the bio-persistence and adverse effects of zinc oxide nanoparticles in the gastropod Monacha cartusiana after short-term exposure, using DNA adduct formation and histopathological defects as biomarkers to characterize cytotoxic and genomic damage from metallic nanoparticle exposure.
The Possible Protective Effect of Luteolin in a Thioacetamide Rat Model of Testicular Toxicity
This animal study tested whether luteolin, a natural plant compound with antioxidant properties, could protect against testicular toxicity caused by thioacetamide. The study establishes an animal model for studying reproductive toxicity and evaluates whether natural antioxidants can mitigate oxidative damage to sperm-producing tissues.
Combined cerium and zinc oxide nanoparticles induced hepato-renal damage in rats through oxidative stress mediated inflammation
Researchers found that exposing rats to cerium oxide and zinc oxide nanoparticles — alone or in combination — caused liver and kidney damage by triggering oxidative stress and inflammatory signaling, with the combined treatment producing distinct toxicity patterns compared to either nanoparticle alone.
Protection of Exogenous Antioxidant of Cinnamomum burmanii as a Hepatoprotective on the Toxicological Responses of Nanoplastics in Rats (Rattus norvegicus L.)
Researchers tested whether Cinnamomum burmanni leaf extract (CLE) protects rat liver function from polystyrene nanoplastic toxicity, administering NPs orally for 14 days with or without 100–400 mg/kg CLE for 28 days. NPs caused oxidative stress and liver damage, while CLE at 200–400 mg/kg significantly reduced hepatotoxicity markers and restored antioxidant enzyme activity, suggesting hepatoprotective potential against nanoplastic-induced toxicity.
Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos
Researchers investigated the toxicity of zinc oxide nanoparticles on human brain glial cells and zebrafish embryos, finding that both were harmed at relatively low concentrations. The nanoparticles reduced cell viability in the glial cells and caused developmental abnormalities in the zebrafish embryos. The study suggests that the dissolved zinc ions released from these widely used nanoparticles play a significant role in their toxic effects on the nervous system.
Toxicity of polystyrene nanoplastics and zinc oxide to mice
Mice injected intraperitoneally with environmentally relevant doses of ZnO nanoparticles or polystyrene nanoplastics showed cognitive impairment in recognition tests, while combined exposure produced genotoxic effects and biochemical stress markers, indicating neurotoxic and genotoxic potential.
Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats
Researchers found that Moringa oleifera leaf extract protected rats from testicular damage caused by uranyl acetate, a toxic uranium compound, by boosting antioxidant defenses and reducing oxidative stress. While focused on uranium toxicity, the protective mechanisms studied are relevant to microplastics research because microplastics also cause testicular damage through oxidative stress in animal studies. Natural antioxidants like those in Moringa may help protect reproductive health from environmental pollutants.
Silica Nanoparticle Acute Toxicity on Male Rattus norvegicus Domestica: Ethological Behavior, Hematological Disorders, Biochemical Analyses, Hepato-Renal Function, and Antioxidant-Immune Response
Researchers assessed the acute toxicity of silica nanoparticles in male rats, finding significant hematological disorders, liver and kidney damage, oxidative stress, and immune system disruption at higher doses after 24 and 96 hours of exposure.
Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats
Researchers orally exposed Wistar rats to polystyrene nanoplastics at multiple doses for five weeks and observed dose-dependent increases in oxidative stress. The study found significant alterations in liver and kidney function markers, disrupted energy metabolism, and changes in antioxidant enzyme activity, suggesting that nanoplastic exposure may affect multiple organ systems in mammals.
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Researchers investigated whether the plant compound chrysoeriol could protect against testicular damage caused by polyethylene microplastics in a rat model. The study found that microplastic exposure reduced antioxidant enzyme activity and increased inflammation markers, while co-administration of chrysoeriol showed a protective effect by mitigating oxidative stress and preserving sperm quality.
Cytotoxicity of Nanoparticles Used in Cosmetic Industries: An In-depth Insight
This review examined the cytotoxicity of nanoparticles used in cosmetic sunscreens, including titanium dioxide and zinc oxide, finding that while these particles provide effective UV protection, their nanoscale form raises concerns about skin penetration and potential cellular toxicity.
Apigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study
Researchers tested whether the flavonoid apigetrin could protect rat testicular tissue from damage caused by the chemotherapy drug doxorubicin. They found that doxorubicin caused significant oxidative stress, inflammation, hormone imbalance, and tissue damage in the testes, but co-administration of apigetrin substantially reduced these harmful effects. The study suggests that natural plant compounds may help protect reproductive health during cancer treatment.
Correction by "Quertin" of the oxidative-antioxidant system of rats at xenobiotics exposure
This study tested whether the antioxidant flavonoid quercetin could protect rats from oxidative damage caused by xenobiotic (foreign chemical) exposure, finding that quercetin administration reduced biomarkers of oxidative stress and liver damage. The results suggest that natural antioxidants may help counteract some biochemical effects of environmental chemical exposures.