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61,005 resultsShowing papers similar to Protective effect of Luffa cylindrica fermentation liquid on cyclophosphamide-induced premature ovarian failure in female mice by attenuating oxidative stress, inflammation and apoptosis
ClearQuercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
Allantoin Derived From Dioscorea opposita Thunb Ameliorates Cyclophosphamide-Induced Premature Ovarian Failure in Female Rats by Attenuating Apoptosis, Autophagy and Pyroptosis
Researchers studied whether allantoin, a compound from a Chinese yam species, could protect female rats from ovarian damage caused by the chemotherapy drug cyclophosphamide. They found that allantoin treatment reduced ovarian cell death through multiple protective pathways and helped preserve ovarian function. While this study does not involve microplastics, it contributes to understanding how natural compounds may help protect reproductive health from toxic chemical exposures.
Apigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study
Researchers tested whether the flavonoid apigetrin could protect rat testicular tissue from damage caused by the chemotherapy drug doxorubicin. They found that doxorubicin caused significant oxidative stress, inflammation, hormone imbalance, and tissue damage in the testes, but co-administration of apigetrin substantially reduced these harmful effects. The study suggests that natural plant compounds may help protect reproductive health during cancer treatment.
Protective effect of Spirulina in the ovary of rats against Doxorubicin toxicity
This experimental study examined whether Spirulina supplementation could protect rat ovaries from toxicity caused by doxorubicin, an anti-cancer agent known to cause reproductive side effects. Spirulina's antioxidant phytopigments including beta-carotene and tocopherols were found to reduce Dox-induced reproductive toxicity in ovarian tissue.
Overview of the evaluation of the destructive effect of procarbazine on the ovarian reserve in the apoptotic, inflammatory, and oxidative pathways
This review evaluated the evidence on procarbazine's toxic effects on ovarian function, examining both clinical data from cancer treatment and experimental findings on mechanisms of ovarian damage. The findings are relevant for fertility preservation in women receiving procarbazine-containing chemotherapy.
Bioactive compounds as potential alternative treatments to prevent cancer therapy-induced male infertility
This review examines bioactive compounds like curcumin and resveratrol as potential non-invasive approaches to help preserve male fertility during cancer treatment. Researchers summarize evidence that these natural compounds may offer chemo-protective effects at the testicular level without the cost and invasiveness of conventional fertility preservation methods. The study suggests that nutritional therapies could complement existing strategies, particularly for younger patients where sperm cryopreservation is not feasible.
Protective effect of Moringa oleifera leaf ethanolic extract against uranyl acetate-induced testicular dysfunction in rats
Researchers found that Moringa oleifera leaf extract protected rats from testicular damage caused by uranyl acetate, a toxic uranium compound, by boosting antioxidant defenses and reducing oxidative stress. While focused on uranium toxicity, the protective mechanisms studied are relevant to microplastics research because microplastics also cause testicular damage through oxidative stress in animal studies. Natural antioxidants like those in Moringa may help protect reproductive health from environmental pollutants.
Metabolic–endocrine remodelling of the testis under polystyrene nanoplastic exposure: Intervention by organ-specific phytocomplexes of Nelumbo nucifera
Researchers found that polystyrene nanoplastics impair testosterone production and sperm quality in male rats by inducing testicular oxidative stress and disrupting cholesterol and energy metabolism, and showed that extracts from lotus plant organs — especially the rhizome — significantly protected testicular function through antioxidant and anti-inflammatory mechanisms.
Morroniside Protects Human Granulosa Cells against H2O2-Induced Oxidative Damage by Regulating the Nrf2 and MAPK Signaling Pathways
Researchers found that morroniside protects human ovarian granulosa cells from oxidative damage by activating the Nrf2 antioxidant pathway and reducing apoptosis through regulation of p38 and JNK signaling pathways.
The Possible Protective Effect of Luteolin in a Thioacetamide Rat Model of Testicular Toxicity
This animal study tested whether luteolin, a natural plant compound with antioxidant properties, could protect against testicular toxicity caused by thioacetamide. The study establishes an animal model for studying reproductive toxicity and evaluates whether natural antioxidants can mitigate oxidative damage to sperm-producing tissues.
Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice
Researchers tested extracts from the plant Allium ochotense for their ability to protect against alcohol-induced liver damage in mice. The study found that the extracts improved lipid metabolism, reduced liver inflammation, and boosted antioxidant defenses, suggesting potential as a natural approach to supporting liver health in the context of chronic alcohol consumption.
Morroniside protect human granulosa cells against H2O2-induced oxidative damage via regulating Nrf2 and MAPK signaling pathway
This study investigated whether morroniside, a compound from the Cornus plant, can protect ovarian cells from oxidative stress-induced damage. The research found protective effects in lab experiments, relevant to understanding how environmental oxidative stressors—including pollutants like microplastics—may affect female reproductive cells.
CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE
Researchers assessed the chemopreventive potential of an alcoholic extract of a polyherbal preparation including Phyllanthus amarus in a precancerous lesion model, measuring effects on biomarkers of oxidative stress and inflammation. The herbal extract reduced key biomarkers compared to untreated controls, supporting further investigation of plant-derived compounds as adjuncts in cancer chemoprevention.
Evaluation of possible attenuative role of chrysoeriol against polyethylene microplastics instigated testicular damage: A biochemical, spermatogenic and histological study
Researchers investigated whether the plant compound chrysoeriol could protect against testicular damage caused by polyethylene microplastics in a rat model. The study found that microplastic exposure reduced antioxidant enzyme activity and increased inflammation markers, while co-administration of chrysoeriol showed a protective effect by mitigating oxidative stress and preserving sperm quality.
Pharmacotherapeutic potential of ginkgetin against polystyrene microplastics–instigated testicular toxicity in rats: A biochemical, spermatological, and histopathological assessment
In a rat study, polystyrene microplastics caused significant damage to the testes, including reduced sperm quality, oxidative stress, and tissue inflammation, but the natural plant compound ginkgetin was able to partially reverse this damage. Ginkgetin worked by boosting antioxidant defenses and reducing the inflammatory response triggered by the microplastics. This suggests that natural antioxidant compounds might help protect male reproductive health from the harmful effects of microplastic exposure.
Modulation efficiency of clove oil nano-emulsion against genotoxic, oxidative stress, and histological injuries induced via titanium dioxide nanoparticles in mice
Researchers found that titanium dioxide nanoparticles (used widely in sunscreens and food products) caused DNA damage, oxidative stress, and organ tissue injury in mice, but that a clove oil nanoemulsion significantly reversed these harmful effects — suggesting a natural antioxidant treatment may protect against nanoparticle toxicity.
Astragalus Polysaccharides Ameliorate the Toxic Effects of Polystyrene Nanoplastics on Boar Sperm
Scientists found that tiny plastic particles called nanoplastics can damage sperm cells by causing harmful chemical reactions, but a natural compound from the Astragalus plant can help protect against this damage. This study used pig sperm in lab dishes, so we don't know yet if the same protection would work in humans. The findings matter because microplastics are everywhere in our environment and food, and this research suggests natural antioxidants might help reduce their potential harm to reproductive health.
Epigallocatechin-gallate ameliorates polystyrene microplastics-induced oxido-inflammation and mitochondria-mediated apoptosis in testicular cells via modulation of Nrf2/HO-1, /mTOR/Atg-7, and Cx-43/NOX-1 levels
Researchers found that polystyrene microplastics caused oxidative stress, inflammation, and reduced sperm quality in rats, but that treatment with EGCG — a compound found in green tea — reversed most of these harmful effects by restoring antioxidant defenses and reducing cell death pathways in testicular tissue.
Lutein Can Alleviate Oxidative Stress, Inflammation, and Apoptosis Induced by Excessive Alcohol to Ameliorate Reproductive Damage in Male Rats
Researchers found that high-dose lutein supplementation alleviated alcohol-induced male reproductive damage in rats by reducing oxidative stress, inflammation, and apoptosis in testicular tissue, restoring sperm quality and sex hormone levels.
Fucoidan from Cladosiphon okamuranus enhances antioxidant activity and prevents reproductive dysfunction in polystyrene microplastic-induced male rats
Researchers tested whether fucoidan, a compound extracted from brown seaweed, could protect against reproductive damage caused by polystyrene microplastic exposure in male rats. They found that fucoidan treatment enhanced antioxidant enzyme activity, reduced inflammation markers, and preserved testicular tissue structure and testosterone levels. The study suggests that fucoidan may help counteract microplastic-induced oxidative stress in reproductive tissues.
Microplastics and nanoplastics in follicular fluid are associated with diminished ovarian reserve: clinical and molecular insights
Researchers found that microplastics and nanoplastics present in follicular fluid are associated with diminished ovarian reserve in women. The study provides evidence suggesting that exposure to these particles may harm female ovarian function. The findings point to the environment-gut-ovarian axis as a potential pathway through which micro- and nanoplastic exposure could contribute to reproductive health concerns.
Attenuative effect of astilbin on polystyrene microplastics induced testicular damage: Biochemical, spermatological and histopathological-based evidences
Researchers found that astilbin, a natural plant compound, significantly reduced testicular damage caused by polystyrene microplastic exposure in rats. The microplastics disrupted hormone levels, sperm quality, and testicular tissue structure, but astilbin treatment counteracted these effects by boosting antioxidant defenses and reducing inflammation. The study suggests that natural antioxidant compounds may offer protective benefits against the reproductive harm associated with microplastic exposure.
Repair mechanism of Yishen Tongluo formula on mouse sperm DNA fragmentation caused by polystyrene microplastics
This study investigated a traditional Chinese medicine formula (Yishen Tongluo) for its potential to repair sperm DNA damage caused by polystyrene microplastics. Researchers found that the formula's protective mechanism may be associated with the PI3K/Akt signaling pathway and the protein SPARC. The study suggests a new direction for using traditional medicine approaches to address reproductive system injury linked to microplastic exposure.
Preparation of Polysaccharides from Qifuyin and Investigation of Their Anti-Oxidant and Regenerative Effects Based on Planaria
Researchers extracted polysaccharides from the traditional Chinese medicine formula Qifuyin using hydrothermal methods, achieving 29.9% yield and 70.1% purity, and investigated their antioxidant and regenerative effects using planaria as a model organism.