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20 resultsShowing papers similar to Oridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cells
ClearOridonin-induced ferroptosis and apoptosis: a dual approach to suppress the growth of osteosarcoma cell
This study investigated the anti-tumor effects of oridonin, a natural plant compound, on osteosarcoma cells, finding it triggered both ferroptosis and apoptosis to suppress tumor growth. While focused on cancer treatment rather than microplastics, the ferroptosis pathway studied is also implicated in cellular damage caused by microplastic exposure.
Melatonin and erastin emerge synergistic anti-tumor effects on oral squamous cell carcinoma by inducing apoptosis, ferroptosis, and inhibiting autophagy through promoting ROS
Researchers found that combining melatonin (a natural hormone) with erastin (a cell-death inducer) produced synergistic anticancer effects in oral cancer cells by triggering multiple forms of cell death simultaneously, suggesting a potentially safer and more effective treatment strategy.
Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS/NF-κB Axis
Researchers investigated whether dendrobine, a natural compound from orchids, could reduce cellular aging and osteoarthritis symptoms in lab and animal models. They found that dendrobine decreased oxidative stress and inflammation by suppressing the ROS/NF-kB signaling pathway, which reduced cartilage breakdown and cellular senescence. The study suggests dendrobine may have potential as a therapeutic approach for age-related joint degeneration.
Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions
This review explores the relationship between the protein GSTP1, ferroptosis (a form of iron-dependent cell death), and radiotherapy resistance in lung cancer. Researchers propose that targeting GSTP1 could help overcome tumor cell resistance to radiation by promoting ferroptosis. While focused on cancer treatment mechanisms, the study touches on how environmental factors and oxidative stress pathways relevant to pollutant exposure intersect with cellular defense mechanisms.
Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis
Researchers investigated the pharmacological mechanisms of Spatholobi Caulis (SC) in reversing osteoporosis, finding it operates through multi-component, multi-target pathways with the AGE-RAGE signaling pathway identified as the primary regulatory mechanism.
Potential application of traditional Chinese medicine in cerebral ischemia—Focusing on ferroptosis
This review examined evidence for traditional Chinese medicine compounds in treating cerebral ischemia by targeting ferroptosis, an iron-dependent form of regulated cell death. Multiple TCM-derived compounds including flavonoids and alkaloids showed neuroprotective effects through ferroptosis pathway inhibition in experimental ischemia models.
Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma
Researchers investigated how polystyrene microplastics promote malignant progression in nasopharyngeal carcinoma cells, finding that the plastics inhibit ferroptosis—an iron-dependent cell death pathway—via the ROS-GPX4 axis, thus allowing cancer cells to survive and proliferate. Blocking this anti-ferroptosis effect restored cancer cell death, suggesting that targeting the ferroptosis pathway could counteract microplastic-driven tumor progression.
Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
The interplay of ferroptosis and oxidative stress in pulmonary fibrosis: from mechanisms to treatment
This research review summarizes how a specific type of cell death called ferroptosis may contribute to pulmonary fibrosis, a serious lung disease where scar tissue builds up and makes breathing difficult. Scientists have found that when cells die from iron buildup and damage from harmful molecules, it can worsen lung scarring, but drugs that block this process show promise in animal studies. Understanding this connection could lead to new treatments for people with pulmonary fibrosis, though more research is needed to make sure these potential medicines are safe and effective in humans.
Connecting Calcium-Based Nanomaterials and Cancer: From Diagnosis to Therapy
Researchers reviewed how calcium-based nanomaterials can be used in cancer diagnosis and treatment, finding that deliberately flooding cancer cells with calcium ions — a process called "calcicoptosis" — can trigger cell death, opening a new avenue for targeted cancer therapy.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma
Researchers investigated how polystyrene microplastics promote malignant progression in nasopharyngeal carcinoma cells. The study found that microplastics inhibit ferroptosis (a form of regulated cell death) through the ROS-GPX4 signaling axis, enhancing cancer cell proliferation, migration, and invasion both in cell cultures and in animal models.
Ferroptosis inhibition via the ROS-GPX4 axis drives microplastic-induced malignant progression of nasopharyngeal carcinoma
Researchers investigated how polystyrene microplastics promote malignant progression in nasopharyngeal carcinoma cells. The study found that microplastics inhibit ferroptosis (a form of regulated cell death) through the ROS-GPX4 signaling axis, enhancing cancer cell proliferation, migration, and invasion both in cell cultures and in animal models.
Tempol Attenuates Methotrexate-Induced Osteotoxicity via Antioxidant Mechanisms: Impairment of Protection by GPX4 Inhibition Through ML210
Researchers investigated the antioxidant compound Tempol as a protective agent against methotrexate-induced bone cell toxicity in murine osteocytes, finding it effectively reversed apoptosis and oxidative stress markers, but that its protective effects were significantly undermined when the GPX4 antioxidant enzyme was inhibited.
Inhibiting ferroptosis in brain microvascular endothelial cells: A potential strategy to mitigate polystyrene nanoplastics‒induced blood‒brain barrier dysfunction
Researchers found that polystyrene nanoplastics disrupt the blood-brain barrier in mice by triggering ferroptosis — an iron-dependent form of cell death — in brain microvascular endothelial cells, and that blocking ferroptosis with a targeted drug reduced tight junction protein loss and restored barrier integrity.
Graphene Oxide (GO) for the Treatment of Bone Cancer: A Systematic Review and Bibliometric Analysis
This systematic review found a strong trend toward using graphene oxide-based nanomaterials for treating osteosarcoma (bone cancer), leveraging their thermal and anti-cancer properties. Photodynamic therapy, photothermal therapy, and nanocarrier delivery systems using GO showed promise as non-invasive, targeted alternatives to conventional bone cancer treatments.
Double-edged Sword Role of Iron-loaded Ferritin in Extracellular Vesicles
This review explores the dual role of iron-loaded ferritin in extracellular vesicles, discussing how excess cellular iron promotes Fenton reaction-driven oxidative DNA damage and cellular ferroptosis resistance, contributing to carcinogenesis.
Ferroptosis induced by environmental pollutants and its health implications
Researchers reviewed how environmental pollutants — including microplastics, PM2.5, and heavy metals — trigger ferroptosis, a form of programmed cell death driven by iron and fat oxidation, finding that targeting this cell death pathway could be a strategy to reduce organ damage caused by pollution exposure.
Understanding the mechanistic roles of microplastics combined with heavy metals in regulating ferroptosis: Adding new paradigms regarding the links with diseases
This review explores the emerging connection between microplastics combined with heavy metals and a type of cell death called ferroptosis, which involves iron-dependent damage to cell membranes. Researchers found that both microplastics and heavy metals can independently trigger ferroptosis, and their combined presence may amplify this effect in organs like the liver, kidneys, and brain. The study suggests that understanding this cell death pathway could provide new insights into how environmental pollutant mixtures contribute to disease.
The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways
Researchers investigated the anticancer potential of an essential oil extracted from Conyza bonariensis against melanoma cells in laboratory experiments. They found that the oil's major compound interacted with key signaling pathways involved in cell survival and induced programmed cell death in melanoma cells. The study suggests this plant-derived compound may warrant further investigation as a potential source of anti-melanoma agents.