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Targeting GSTP1-dependent ferroptosis in lung cancer radiotherapy: Existing evidence and future directions
Summary
This review explores the relationship between the protein GSTP1, ferroptosis (a form of iron-dependent cell death), and radiotherapy resistance in lung cancer. Researchers propose that targeting GSTP1 could help overcome tumor cell resistance to radiation by promoting ferroptosis. While focused on cancer treatment mechanisms, the study touches on how environmental factors and oxidative stress pathways relevant to pollutant exposure intersect with cellular defense mechanisms.
Radiotherapy is applied in about 70% patients with tumors, yet radioresistance of tumor cells remains a challenge that limits the efficacy of radiotherapy. Ferroptosis, an iron-dependent lipid peroxidation regulated cell death, is involved in the development of a variety of tumors. Interestingly, there is evidence that ferroptosis inducers in tumor treatment can significantly improve radiotherapy sensitivity. In addition, related studies show that Glutathione S-transferase P1 (GSTP1) is closely related to the development of ferroptosis. The potential mechanism of targeting GSTP1 to inhibit tumor cells from evading ferroptosis leading to radioresistance has been proposed in this review, which implies that GSTP1 may play a key role in radiosensitization of lung cancer via ferroptosis pathway.
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