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61,005 resultsShowing papers similar to Integrative network toxicology and molecular docking preliminarily explore the potential role of polystyrene microplastics in childhood obesity
ClearIntegrative network toxicology and molecular docking preliminarily explore the potential role of polystyrene microplastics in childhood obesity
Researchers used computational methods including network toxicology, machine learning, and molecular docking to explore how polystyrene microplastics might contribute to childhood obesity. They identified 40 overlapping genes between obesity-related and microplastic-affected pathways, concentrated in lipid metabolism and insulin signaling. The study suggests that polystyrene microplastics may act as environmental triggers capable of disrupting metabolic balance by interacting with key regulatory genes.
Integrative network toxicology and molecular docking preliminarily explore the potential role of polystyrene microplastics in childhood obesity
This study found that tiny plastic particles called polystyrene microplastics (found in food packaging and disposable cups) may contribute to childhood obesity by disrupting how the body processes fats and controls metabolism. The researchers discovered that these plastic particles can bind to and interfere with key genes responsible for managing cholesterol and insulin in the body. While more research is needed, these findings suggest parents should try to limit their children's exposure to disposable plastic food containers as a precaution against obesity risk.
Assessing the toxicological effects of exposure to environmental pollutants PET-MPs on vascular diseases: insights from network toxicology, molecular docking, molecular dynamics, and experimental validation
Researchers used network toxicology, molecular docking, and cell experiments to investigate how PET microplastics may contribute to vascular diseases. They identified four core molecular targets and found that PET microplastics induced mitochondrial oxidative stress, increased reactive oxygen species, and promoted vascular smooth muscle cell death. The study provides initial molecular-level evidence that microplastic exposure may be a contributing factor in vascular damage and remodeling.
Mechanistic study of plastic monomers in gestational diabetes mellitus: A network toxicology and molecular docking approach
Using network toxicology and molecular docking, researchers investigated how plastic monomers interact with molecular targets involved in gestational diabetes mellitus (GDM). The analysis identified shared gene targets and signaling pathways linking plastic monomer exposure to insulin resistance and inflammatory mechanisms relevant to GDM development.
The toxicological impact of PET-MPs exposure on atherosclerosis: insights from network toxicology, molecular docking, and machine learning
Researchers used network toxicology, molecular docking, and machine learning to identify how PET microplastics may promote atherosclerosis, narrowing 28 candidate targets to seven key genes and predicting interactions with atherosclerosis-relevant pathways including inflammation and lipid metabolism.
Microplastic exposure and allergic rhinitis: Network toxicology, and molecular docking insights
Researchers used network toxicology and molecular docking approaches to investigate how microplastic exposure may contribute to allergic rhinitis. The study identified key molecular mediators through which microplastics may drive respiratory inflammation pathways, and found that resveratrol could potentially modulate these pathways, offering insights into the mechanisms linking microplastic exposure to allergic respiratory conditions.
Exploring the Potential Mechanism of Polyethylene Terephthalate Associated Cardiotoxicity through Network Toxicology and Molecular Docking
Researchers used computational approaches including network toxicology, molecular docking, and molecular dynamics simulations to explore how polyethylene terephthalate microplastics may affect cardiovascular function. The study identified potential molecular pathways through which PET exposure could contribute to cardiotoxicity. The findings provide a theoretical framework for understanding how plastic contaminants might interact with heart-related biological targets.
Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice
Researchers used gene expression and metabolic profiling to understand how polystyrene nanoplastics harm mice at the molecular level, finding disrupted energy metabolism, fat processing, and amino acid pathways in the liver. These molecular changes suggest that nanoplastic exposure could contribute to metabolic disorders, with effects becoming more severe at higher doses.
Environmental PET-microplastic exposure and risk of non-alcoholic fatty liver disease: An integrated computational toxicology and multi-omics study
Researchers used computational toxicology and machine learning to identify six key genes linking PET microplastic exposure to non-alcoholic fatty liver disease (NAFLD), with the model achieving high diagnostic accuracy and molecular docking suggesting that PET-derived chemicals may directly bind to proteins controlling liver fat metabolism.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Network toxicology and bioinformatics analysis reveal the molecular mechanisms of polyethylene terephthalate microplastics in exacerbating diabetic nephropathy
This computational study used bioinformatics to explore how polyethylene terephthalate (PET) microplastics might worsen diabetic kidney disease. The analysis identified key genes and inflammatory pathways that are affected by both PET microplastics and kidney damage in diabetes. The findings suggest that microplastic exposure could accelerate kidney problems in people who already have diabetes, though lab and clinical studies are needed to confirm this.
A computational framework for multi-scale data fusion in assessing the associations between micro- and nanoplastics and human hepatotoxicity
Researchers developed a computational toxicology framework integrating multi-source data and network analysis to map associations between micro- and nanoplastics and hepatotoxicity, identifying key molecular pathways through which MNPs may damage the liver, offering a scalable alternative to traditional in vivo testing.
Evaluating the toxicological effects of PET-MPs exposure on atherosclerosis through integrated network toxicology analysis and experimental validation
Researchers used network toxicology analysis and laboratory experiments to investigate how polyethylene terephthalate microplastics may contribute to atherosclerosis. They identified several molecular targets and biological pathways through which these microplastics could promote plaque formation in blood vessels. The study provides preliminary evidence that a commonly encountered type of microplastic may interact with cardiovascular disease mechanisms, though further research is needed to confirm these findings.
Toxicity evaluation of microplastics to aquatic organisms through molecular simulations and fractional factorial designs
Researchers used molecular docking, molecular dynamics, and fractional factorial design to evaluate the toxicity of ten common microplastic types to zebrafish, identifying polystyrene and polyvinylchloride as the most toxic based on binding interactions with key biological proteins.
Integrated transcriptomic and metabolomic analyses to decipher the regulatory mechanisms of polystyrene nanoplastic-induced metabolic disorders in hepatocytes
Using combined transcriptomic and metabolomic analysis, this study found that polystyrene nanoplastics disrupt lipid and amino acid metabolism in hepatocytes, identifying key regulatory genes and providing data relevant to assessing health risks from nanoplastic exposure.
In silico insights into microplastic additive toxicity: Risks of pulmonary fibrosis and endocrine disruption
Researchers used computational modeling to investigate how five common microplastic additives, including phthalates and flame retardants, interact with proteins involved in lung fibrosis and endocrine function. Molecular docking revealed that these additives bind strongly to fibrotic markers like TGF-beta and to hormone receptors, suggesting potential mechanisms for tissue damage and hormonal disruption. The study highlights the need for further investigation into the health risks posed by chemical additives leaching from microplastics.
Exploring the prognostic implications of PET microplastic degradation products in colorectal cancer: insights from an integrated computational analysis on glucocorticoid pathway–mediated mechanisms
Combining network toxicology, machine learning, and molecular docking, this study found that PET plastic degradation products ethylene glycol and terephthalic acid may influence colorectal cancer prognosis through 43 shared genes linked to TNF/IL-17 signaling and glucocorticoid-mediated metabolic pathways.
Integrated network toxicology, machine learning, molecular docking and experimental validation to elucidate mechanism of polyethylene terephthalate microplastics inducing periodontitis
Researchers combined computational biology, machine learning, and laboratory experiments to explore how polyethylene terephthalate microplastics might contribute to periodontitis, a common gum disease. They identified key molecular targets and signaling pathways through which microplastics could promote gum tissue inflammation. The study provides the first evidence linking microplastic exposure to the biological mechanisms underlying periodontal disease.
Size-Dependent Disruption of Lipid Metabolism by Polystyrene Micro- and Nanoplastics in Caenorhabditis elegans Revealed Through Multi-Omics and Functional Genetic Validation
Researchers used the model organism C. elegans to study how polystyrene particles of different sizes affect lipid metabolism, finding that both 100-nanometer and 1-micrometer particles disrupted fat storage and lipid processing. Multi-omics analysis identified four core genes governing the size-dependent metabolic disruption, and elevated levels of specific lipid metabolites confirmed that microplastics can meaningfully interfere with lipid homeostasis.
Mixtures of polystyrene micro and nanoplastics affects fat and glucose metabolism in 3T3-L1 adipocytes and zebrafish larvae
Exposure to a mixture of micro- and nanoplastics increased fat production and impaired the body's ability to use insulin and process sugar in both cell and zebrafish experiments. The plastic mixture triggered inflammation, boosted fat-storing genes, and suppressed insulin signaling pathways. These findings suggest that microplastic exposure could contribute to obesity and type 2 diabetes.
Transcriptomic Meta-Analysis Unveils Shared Neurodevelopmental Toxicity Pathways and Sex-Specific Transcriptional Signatures of Established Neurotoxicants and Polystyrene Nanoplastics as an Emerging Contaminant
This meta-analysis compared gene expression patterns caused by nanoplastics with those from known brain-toxic chemicals like BPA. It found that polystyrene nanoplastics activate many of the same harmful pathways as established neurotoxicants, with some effects differing between males and females, suggesting plastic particles may pose similar risks to brain development.
The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis
A rat study using metabolomics analysis found that long-term exposure to high concentrations of polystyrene microplastics led to abnormal fat metabolism and cardiovascular damage. The harm appeared to be driven by oxidative stress and inflammation, suggesting that chronic microplastic exposure could contribute to heart and blood vessel disease.
Analyzing the toxicological effects of PET-MPs on male infertility: Insights from network toxicology, mendelian randomization, and transcriptomics
Using network toxicology, Mendelian randomisation, and transcriptomic analysis, researchers identified mechanisms by which PET microplastics may impair male fertility, linking shared gene targets to testicular oxidative stress, hormonal disruption, and spermatogenesis interference. The multi-evidence approach strengthens the case for a causal role of PET-MP exposure in male infertility.
Potential nervous threat of nanoplastics to Monopterus albus: Implications from a metabolomics study
Researchers used metabolomics to investigate the neurotoxic potential of polystyrene nanoplastics on the Asian swamp eel at different concentrations. The study found that nanoplastics significantly altered metabolic pathways in the nervous system, with lower concentrations surprisingly producing greater changes in differential metabolites than higher concentrations, suggesting complex dose-response relationships.