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Microplastic exposure and allergic rhinitis: Network toxicology, and molecular docking insights
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Researchers used network toxicology and molecular docking approaches to investigate how microplastic exposure may contribute to allergic rhinitis. The study identified key molecular mediators through which microplastics may drive respiratory inflammation pathways, and found that resveratrol could potentially modulate these pathways, offering insights into the mechanisms linking microplastic exposure to allergic respiratory conditions.
MPs drive AR pathogenesis through respiratory toxicity pathways, with DNAJB9, SQSTM1, and MAPK9 serving as critical molecular mediators. Resveratrol, by modulating target-mediated programmed cell death, emerges as a promising therapeutic candidate for mitigating MP-induced AR.
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Intersection of microplastic toxicity targets and differentially expressed genes in allergic rhinitis.
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Network analysis identified a set of genes that are both targeted by common microplastics (PE, PP, PVC, PS) and differentially expressed in allergic rhinitis, providing a molecular framework for investigating how microplastic exposure may contribute to nasal allergy pathogenesis.
Assessing the toxicological effects of exposure to environmental pollutants PET-MPs on vascular diseases: insights from network toxicology, molecular docking, molecular dynamics, and experimental validation
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Researchers used network toxicology, molecular docking, and cell experiments to investigate how PET microplastics may contribute to vascular diseases. They identified four core molecular targets and found that PET microplastics induced mitochondrial oxidative stress, increased reactive oxygen species, and promoted vascular smooth muscle cell death. The study provides initial molecular-level evidence that microplastic exposure may be a contributing factor in vascular damage and remodeling.
Correction: Microplastic exposure and allergic rhinitis: Network toxicology, and molecular docking insights
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This entry is a published correction to an earlier paper on microplastic exposure and allergic rhinitis that used network toxicology and molecular docking methods. No new findings were reported; the correction addresses an error in the original article.
Protein-protein network analysis.
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This study presents a protein-protein interaction network and LASSO regression analysis identifying key molecular targets through which microplastics may act in allergic rhinitis, using STRING database clustering and Genemama functional enrichment. The analysis identified three key gene targets and constructed a microplastic-target-pathway network to elucidate potential mechanistic pathways of microplastic-associated disease.
Integrative Analysis of Pharmacology and Transcriptomics Predicts Resveratrol Will Ameliorate Microplastics-Induced Lung Damage by Targeting Ccl2 and Esr1
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Researchers used pharmacology network analysis and transcriptomics to predict that resveratrol may help mitigate lung damage caused by microplastic exposure. They identified two key molecular targets, Ccl2 and Esr1, through which resveratrol could exert protective effects. The study offers a new perspective on potential approaches to addressing microplastic-induced lung injury, though further experimental validation is needed.
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