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61,005 resultsShowing papers similar to Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
ClearEmerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This review examined the emerging mechanisms by which microplastics may contribute to skin diseases through the gut-skin axis. Researchers found evidence that microplastics can induce gut microbiota dysbiosis and compromise intestinal barrier integrity, which in turn may impair skin barrier function and trigger inflammatory skin conditions through shared immunological and neuroendocrine pathways.
Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This review explores how microplastics may cause skin damage through the gut-skin axis, a system connecting intestinal and skin health through immunological and neuroendocrine pathways. The study suggests that microplastics can disrupt gut microbial balance and intestinal barrier integrity, allowing harmful bacteria and metabolites to enter the bloodstream and contribute to skin inflammation, metabolic imbalance, and oxidative stress.
Additional file 1 of Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This paper provides supplementary material for a review on microplastic-induced skin diseases through the gut-skin axis. The parent study examined how microplastics disrupt gut microbiota and intestinal barrier integrity, potentially contributing to inflammatory skin conditions via shared immune and neuroendocrine signaling.
Additional file 1 of Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This paper provides supplementary material for a review on microplastic-induced skin diseases through the gut-skin axis. The parent study examined how microplastics disrupt gut microbiota and intestinal barrier integrity, potentially contributing to inflammatory skin conditions via shared immune and neuroendocrine signaling.
Gut microbiota as an emerging target for the health implications of microplastics
This review examines how microplastic exposure disrupts the gut microbiome, finding evidence that microplastics damage intestinal barrier proteins, promote inflammation and oxidative stress, and may drive systemic effects including neurotoxicity and reproductive toxicity through gut-mediated pathways.
Skin, gut, and lung barrier: Physiological interface and target of intervention for preventing and treating allergic diseases
This review summarizes how the protective barriers of our skin, gut, and lungs can be damaged by environmental factors including microplastics, leading to allergic conditions like asthma, food allergies, and eczema. The authors explain that a person's genetics, microbiome, and environmental exposures all contribute to barrier breakdown, and they highlight current treatments as well as gaps in care for these increasingly common conditions.
Microplastics and the gut-brain axis: Unraveling neurotoxic mechanisms and health implications
This review examines how microplastics interact with the gut-brain axis, a communication network linking the digestive system to the central nervous system. Researchers found that microplastics can disrupt intestinal barrier integrity, alter gut microbiota composition, and trigger systemic inflammation that may affect neurotransmitter balance and brain function. The study suggests that chronic microplastic exposure through the diet could contribute to neurological effects through inflammatory and oxidative stress pathways.
Microplastics and the gut microbiome: Emerging health concerns and strategies
This review covers how microplastic ingestion affects the gut microbiome, describing mechanisms by which microplastics cause intestinal disorders, disrupt endocrine function, and promote pathogenic bacterial growth, while also noting inhalation and dermal absorption as secondary exposure routes.
Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis.
This review provided mechanistic insight into how micro/nano-plastic-induced gut dysbiosis drives neurodegeneration, tracing a pathway from intestinal microbiome disruption to neuroinflammation and brain damage. It identified the gut-brain axis as the critical link between plastic particle exposure and progressive neurodegenerative conditions.
Gut Microbiota and Extraintestinal Disorders: Are They Interrelated?
This review examines how disturbances to the gut microbiome — the community of bacteria living in the digestive tract — are linked not just to intestinal diseases but also to allergies, asthma, and cardiovascular conditions. This context is relevant to microplastics research because ingested plastic particles have been shown to alter gut microbial communities.
Innovative mechanisms of micro- and nanoplastic-induced brain injury: Emphasis on the microbiota-gut-brain axis
This review summarizes how micro- and nanoplastics may damage the brain through the gut-brain axis, a communication pathway between the digestive system and the nervous system. Nanoplastics can disrupt gut bacteria and weaken the intestinal barrier, potentially sending inflammatory signals to the brain. The authors suggest that targeting gut health could be a way to reduce brain damage caused by nanoplastic exposure.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Health risk analysis of micro-and nanoplastic exposure via the microbiota-gut-brain axis
This review examines how micro- and nanoplastics that accumulate in the gastrointestinal tract may disrupt the microbiota-gut-brain axis through neural, immune, and endocrine pathways. The study suggests that these particles can interfere with normal gut microbiota function after entering the body through diet, inhalation, and skin contact, potentially inducing or worsening health effects.
Microplastics in dermatology: Potential effects on skin homeostasis
This study highlights the growing concern that microplastics and nanoplastics may affect skin health by disrupting the skin's natural balance. While research is still early, the findings suggest that these synthetic particles could interfere with skin homeostasis, pointing to a need for further investigation into how everyday plastic exposure might affect our largest organ.
Intestinal barrier dysfunction and food allergy
This review applies the epithelial barrier hypothesis to food allergy, arguing that environmental exposures including microplastics, nanoplastics, food additives, and detergents disrupt gut and skin barriers and drive the rise in allergic disease.
Perturbation of gut microbiota plays an important role in micro/nanoplastics-induced gut barrier dysfunction
Researchers investigated how micro- and nanoplastics disrupt gut barrier function in mice, finding that different surface chemistries caused varying levels of damage. The study suggests that these plastic particles harm the gut by altering the gut microbiome, which then leads to inflammation and weakening of the intestinal barrier that normally keeps harmful substances out of the body.
Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks
This review summarizes evidence that microplastics disrupt the gut microbiome, the community of bacteria in our digestive system that plays a key role in immunity, metabolism, and overall health. By altering gut bacteria balance and triggering inflammation, microplastic exposure may contribute to chronic conditions including inflammatory bowel disease, metabolic disorders, and potentially even neurological problems through the gut-brain connection.
Immunotoxicity and intestinal effects of nano- and microplastics: a review of the literature
This review examines the evidence on how nano- and microplastics affect the immune system and intestinal health. The findings suggest that exposure to these particles can disrupt the gut microbiome and impair critical intestinal barrier functions, potentially contributing to the development of chronic inflammatory and immune conditions.
Microplastics, Skin Disease, and Dermatology
This review examined the risks that microplastics and nanoplastics pose to skin health, noting that particles can penetrate compromised skin barriers and cause oxidative stress, inflammation, and cellular senescence in fibroblasts. The authors recommend that dermatologists incorporate microplastic exposure into clinical assessments of skin conditions.
Micro- and Nanoplastics as Emerging Environmental Materials: GreenChemistry Insights into Gut Microbiota Disruption and Chronic DiseasePathways
Researchers reviewed how micro- and nanoplastics accumulate in the gastrointestinal tract and disrupt gut microbiota composition, finding evidence linking these exposures to reduced microbial diversity, gut barrier dysfunction, systemic inflammation, and potential contributions to chronic diseases including metabolic disorders and neurodegeneration.
Epithelial Barrier: Protector and Trigger of Allergic Disorders
This review explores the epithelial barrier hypothesis, which proposes that disruption of skin, lung, and gut epithelial barriers by environmental exposures such as microplastics and pollutants drives the rising incidence of allergic and inflammatory diseases.
Micro(nano)plastics in food system: potential health impacts on human intestinal system.
This review assessed how micro(nano)plastics in the human food system reach the intestine and accumulate in the gut, summarizing evidence that they can alter intestinal barrier function, trigger inflammation, and disrupt the gut microbiome, with implications for long-term digestive health.
Nanoplastic Impact on the Gut-Brain Axis: Current Knowledge and Future Directions
Researchers reviewed the emerging evidence on how nanoplastics may affect the gut-brain axis, the communication pathway between the digestive and nervous systems. Studies indicate that nanoplastic exposure can alter gut microbiota, increase intestinal permeability, trigger oxidative stress and inflammation, and produce neurotoxic and behavioral effects. The review calls for more research given the ubiquitous presence of plastics in the human environment and the potential for nanoplastics to disrupt this critical biological communication pathway.
Impacts of microplastics on gut health: Current status and future directions
This systematic review found consistent evidence across mouse, fish, and earthworm models that microplastics disrupt gut microbiota composition, impair intestinal barrier integrity, and trigger gastrointestinal inflammation. The correlation between microplastic exposure and gut health deterioration was statistically significant across all animal models examined.