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61,005 resultsShowing papers similar to CHEMOPREVENTIVE POTENTIAL OF ALCOHOLIC EXTRACT OF A POLYHERBAL ( Phyllanthus amarus, Euphorbia hirta and Azadirachta indica) RECIPE AGAINST BENZO(a)PYRENE INDUCED LUNG CARCINOGENESIS IN ALBINO MICE
ClearChemoprophylaxis of precancerous lesions in patients who are at a high risk of developing colorectal cancer (Review)
This review covers chemoprevention strategies for precancerous lesions in patients at elevated cancer risk, evaluating evidence for pharmacological and dietary interventions including natural compounds that modulate carcinogenic pathways. The authors assess clinical trial evidence and identify specific compounds with strong evidence for reducing progression from precancerous to malignant lesions.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight
This review examines the anticancer mechanisms of polydatin, a natural stilbenoid compound, detailing its ability to inhibit tumor growth through antioxidant, anti-inflammatory, and apoptotic pathways across multiple cancer types.
Protective Effects of Nelumbo nucifera Extracts on Lung Exposed to Polystyrene Nanoplastics; Histological and Phytochemical Analysis
Researchers evaluated the protective effects of lotus (Nelumbo nucifera) extracts from leaves, flowers, and rhizomes on rat lungs exposed to polystyrene nanoplastics. The nanoplastics caused significant respiratory damage through oxidative stress and inflammation, which was partially mitigated by the plant extracts. The study suggests that bioactive compounds from lotus may offer some protection against nanoplastic-induced lung injury.
The Potential Role and Effective Components of Sanyeqing as the Potential Therapeutic Candidates for IBD and CRC
This review examines the phytochemical constituents of Sanyeqing (a traditional medicinal plant) and their therapeutic potential for inflammatory bowel disease and colorectal cancer, identifying anti-inflammatory and anti-tumor mechanisms that could complement conventional treatments.
Genotoxicity Assessment of Hwanglyeonhaedok-Tang: An Herbal Formula Evaluated Using the In Vivo Alkaline Comet Assay and Pig-a Gene Mutation Assay in Rats
Researchers tested whether the traditional Asian herbal formula Hwanglyeonhaedok-tang caused DNA damage in rats using in vivo comet and Pig-a gene mutation assays, following earlier positive in vitro genotoxicity results. The in vivo assays did not confirm genotoxicity, suggesting the previous signals may be false positives under realistic dosing conditions.
[Screening of quality markers and activity verification of Glycyrrhizae Radix et Rhizoma based on small molecule compound-protein interaction].
Researchers screened 27 chemical compounds in licorice root (Glycyrrhizae Radix) to identify quality markers by measuring how strongly each compound binds to mouse organ proteins. Seven active components were identified, and their anti-inflammatory and antioxidant properties were confirmed in a cell model where macrophages were stressed using microplastics.
Protective effect of Luffa cylindrica fermentation liquid on cyclophosphamide-induced premature ovarian failure in female mice by attenuating oxidative stress, inflammation and apoptosis
Researchers tested a fermented extract from loofah plants (Luffa cylindrica) as a treatment for chemotherapy-induced ovarian failure in mice, finding it significantly restored hormone levels and reduced ovarian cell damage by suppressing inflammation and cell death pathways. The results suggest this natural fermentation product may help protect fertility in women undergoing toxic chemotherapy treatments.
Erchen Decoction Alleviates High-Fat Diet + AOM/DSS-Induced CRC by Ameliorating Cholesterol-Bile Acid Metabolism Disorder through Regulating FXR and the Gut Microbiota
Researchers found that Erchen Decoction, a traditional Chinese medicine formula, alleviates colorectal cancer progression in a high-fat diet mouse model by correcting cholesterol-bile acid metabolism disorders through modulation of FXR signaling and gut microbiota composition.
Protective Effects of Nelumbo nucifera Extracts on Lung Exposed to Polystyrene Nanoplastics; Histological and Phytochemical Analysis
Researchers tested whether extracts from lotus plant (Nelumbo nucifera) leaves, flowers, and rhizomes could protect rat lungs from polystyrene nanoplastic-induced damage. All three extracts reduced lung histological damage caused by PS-NP exposure, with rhizome extract showing the strongest protective effect.
Artemisia gmelinii Extract Attenuates Particulate Matter-Induced Neutrophilic Inflammation in a Mouse Model of Lung Injury
Researchers tested whether Artemisia gmelinii extract could reduce particulate matter-induced neutrophilic lung inflammation in mice, finding that it significantly decreased inflammatory chemokines, neutrophil extracellular trap formation, and total inflammatory cell counts in bronchoalveolar lavage fluid. The plant extract shows potential as a natural therapeutic agent for managing particulate matter-induced respiratory inflammation.
Renoprotective Effect of Chrysanthemum coronarium L. Extract on Adenine-Induced Chronic Kidney Disease in Mice
Researchers investigated the renoprotective effects of Chrysanthemum coronarium extract on adenine-induced chronic kidney disease in mice, finding it reduced inflammation and fibrosis markers associated with progressive loss of renal function.
Chemical Profiling and Biological Activity of Psydrax dicoccos Gaertn
This study profiled the chemical composition and biological activity of Psydrax dicoccos leaf and bark extracts, testing their potential against breast cancer cells as a safer natural alternative to synthetic chemotherapy drugs.
Anti-Inflammatory Effectiveness of Sungkai Leaf Extract (Peronema Canescens) Against Lung Histopathological Appearance, Polymorphonuclear Cell (PMN) Number, and Macrophages in Inflammatory Model Mice with Covid-19 Vaccine Induction
Researchers evaluated the anti-inflammatory effectiveness of Sungkai leaf extract (Peronema canescens) in a murine model of inflammation induced by COVID-19 vaccine, measuring effects on lung histopathology, polymorphonuclear cell infiltration, and macrophage counts. The study found that flavonoid-rich Sungkai extract reduced inflammatory markers in lung tissue, suggesting potential as a complementary anti-inflammatory botanical treatment.
Potential of Macang (Mangifera foetida) Bark Extract on Antioxidant Levels and Pro-Apoptotic Proteins in Rats (Rattus norvegicus) Exposed to Polystyrene Nanoplastics
Researchers assessed whether Mangifera foetida (macang) bark extract could protect male rats against reproductive and immune damage caused by polystyrene nanoplastic exposure, finding that the extract's antioxidant compounds partially restored superoxide dismutase activity and reduced apoptosis markers at 500 mg/kg doses.
Hepatoprotective Effect of Allium ochotense Extracts on Chronic Alcohol-Induced Fatty Liver and Hepatic Inflammation in C57BL/6 Mice
Researchers tested extracts from the plant Allium ochotense for their ability to protect against alcohol-induced liver damage in mice. The study found that the extracts improved lipid metabolism, reduced liver inflammation, and boosted antioxidant defenses, suggesting potential as a natural approach to supporting liver health in the context of chronic alcohol consumption.
Antioxidant Potential of Mangifera foetida Bark, Mangifera foetida Leaves, and Cinnamomum burmanii Leaves Extract in Mitigating Nanoplastic‐Induced Toxicity and Disruption of Glycolipid Metabolism
Researchers tested whether plant extracts from Mangifera foetida and Cinnamomum burmanii could reduce nanoplastic-induced metabolic disruption in rats, finding that the antioxidant compounds in these extracts partially mitigated nanoplastic-associated disruption of glycolipid metabolism.
Syringodium isoetifolium Fosters an Antioxidant Defense System, Modulates Glycolytic Enzymes and Protects Membrane Integrity in DEN-induced Hepatocellular Carcinoma in Albino Wistar Rats
This paper is not about microplastics; it investigates the anti-cancer properties of Syringodium isoetifolium seagrass extract in a rat model of liver cancer, finding reduced tumor growth and restored liver tissue architecture.
Hesperidin inhibits tobacco smoke‑induced pulmonary cell proliferation and EMT in mouse lung tissues via the p38 signaling pathway
Researchers found that hesperidin, a natural flavonoid compound, inhibits tobacco smoke-induced lung cell proliferation and epithelial-mesenchymal transition in mice by suppressing the p38 signaling pathway, suggesting a potential role in reducing lung cancer risk.
Dimethyl Bisphenolate Ameliorates Carbon Tetrachloride-Induced Liver Injury by Regulating Oxidative Stress-Related Genes
Researchers synthesized a novel compound called dimethyl bisphenolate and tested its ability to protect against chemically induced liver injury in rats and cell models. They found that the compound significantly reduced liver damage markers and oxidative stress in a dose-dependent manner, with effects comparable to the established liver protectant silymarin. The study suggests that dimethyl bisphenolate may help protect liver cells by regulating oxidative stress pathways and reducing cell death.
Pneumotoxicity of Styrene Oxide and the Possible Protective Role of Thymosin β4 in Albino Rat: Biochemical and Immunohistochemical Study
Researchers found that styrene oxide — a metabolite of the plastic-related compound styrene — caused significant lung tissue damage, inflammation, and oxidative stress in rats, while co-administration of thymosin β4 protein substantially reduced these toxic effects.
Quercetin alleviates cyclophosphamide-induced premature ovarian insufficiency in mice by reducing mitochondrial oxidative stress and pyroptosis in granulosa cells
Researchers found that quercetin, a natural plant compound, protected mouse ovaries from chemotherapy-induced damage by reducing harmful oxidative stress in mitochondria and suppressing a form of inflammatory cell death called pyroptosis, suggesting it could help preserve fertility in patients undergoing cancer treatment.
Glycyrrhizin Alleviates the Damage Caused by Zearalenone and Protects the Glandular Stomach of Chickens
Researchers investigated whether glycyrrhizin, a natural compound from licorice root, could protect chicken stomach tissue from damage caused by the fungal toxin zearalenone. They found that glycyrrhizin reduced inflammation, oxidative stress, and cell death in glandular stomach cells exposed to the toxin. The study suggests that natural plant extracts may offer protective benefits against common agricultural contaminants in poultry.
Apigetrin ameliorates doxorubicin prompted testicular damage: biochemical, spermatological and histological based study
Researchers tested whether the flavonoid apigetrin could protect rat testicular tissue from damage caused by the chemotherapy drug doxorubicin. They found that doxorubicin caused significant oxidative stress, inflammation, hormone imbalance, and tissue damage in the testes, but co-administration of apigetrin substantially reduced these harmful effects. The study suggests that natural plant compounds may help protect reproductive health during cancer treatment.
Huperzine A ameliorates neurological deficits after spontaneous subarachnoid hemorrhage through endothelial cell pyroptosis inhibition
Researchers investigated how the compound Huperzine A affects brain damage following spontaneous subarachnoid hemorrhage in rats. They found that the treatment reduced blood-brain barrier damage and brain swelling by blocking a type of inflammatory cell death in blood vessel cells. The study suggests that Huperzine A may offer protective benefits for brain health after hemorrhagic stroke through its anti-inflammatory and antioxidant properties.