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Papers
20 resultsShowing papers similar to Risk factors for the prevalence and development of allergic diseases
ClearThe interconnection between environment, immune-nutrition and allergic disease
This review explores the connections between environmental factors, immune-nutrition, and the rising global prevalence of allergic diseases. The study discusses how climate change, air pollution, biodiversity loss, and environmental contaminants including microplastics contribute to immune dysregulation, and highlights the role of the microbiome and dietary factors in modulating allergic disease risk.
Cellular and molecular mechanisms of allergic asthma
Researchers reviewed the cellular and molecular mechanisms behind allergic asthma, finding that rising exposure to environmental pollutants — including microplastics — likely contributes to the disease's increasing prevalence, as pollutants disrupt airway barrier integrity and trigger immune responses that lead to chronic airway inflammation.
Confronting allergies: strategies for combating pollution and safeguarding our health
This review examined the growing body of evidence linking environmental pollutants, including airborne microplastics, to increasing rates of allergic reactions worldwide. Researchers found that air pollution and indoor contaminants can worsen respiratory allergies, while climate change intensifies seasonal allergy patterns. The study emphasizes the need for comprehensive action including government regulation and public awareness to reduce pollution-driven allergy risks.
One Health in allergology: A concept that connects humans, animals, plants, and the environment
This review applies the One Health framework to allergology, arguing that the increasing prevalence of allergic diseases reflects interconnections between human, animal, and environmental health, with environmental contaminants including microplastics among the discussed contributing factors.
Alergia alimentaria y contaminación ambiental
This paper is not primarily about microplastics; it reviews how environmental exposures — including air pollutants and poor waste management — contribute to allergic disease in children, with microplastics mentioned only briefly as one component of the broader environmental exposome.
Epithelial barrier hypothesis: Effect of the external exposome on the microbiome and epithelial barriers in allergic disease
This review proposes the 'epithelial barrier hypothesis,' which suggests that modern environmental exposures, including microplastics, air pollution, and processed food additives, are damaging the protective barriers of our skin, gut, and airways. When these barriers break down, foreign substances and bacteria can enter the body and trigger allergic and inflammatory diseases, which have been increasing rapidly in recent decades. The research suggests microplastics may be one of many environmental factors driving the rise in conditions like asthma, food allergies, and eczema.
Allergy and immunotoxicology in preventive and clinical medicine from theory to practice: Environmental factors in bronchial asthma
This review applies an exposome framework to bronchial asthma, identifying living-environment pollutants including microplastics, air pollution, tobacco smoke, climate change, and dietary changes as contributors to asthma pathogenesis and exacerbation.
Intestinal barrier dysfunction and food allergy
This review applies the epithelial barrier hypothesis to food allergy, arguing that environmental exposures including microplastics, nanoplastics, food additives, and detergents disrupt gut and skin barriers and drive the rise in allergic disease.
Airway exposure to microplastics: Potential mechanisms from epithelial barrier damage to the development of allergic rhinitis
This review summarized the mechanisms by which airborne microplastic exposure triggers allergic rhinitis, identifying pathways including physical and chemical disruption of the airway epithelial barrier, oxidative stress from adsorbed pollutants, and induction of Th2 immune responses and IgE class-switching. The findings support airborne MPs as a novel trigger for upper respiratory allergic disease.
The Impact of Microplastics on Allergy: Current Status and Future Research Directions
This study reviews current evidence on how microplastics may influence allergic responses, noting that microplastics can compromise epithelial barriers and promote type 2 inflammation associated with allergies. The authors emphasize an urgent need for research into dose-dependent immunotoxicological mechanisms to better understand the relationship between microplastic exposure and allergy development. The study calls for evidence-based policies to reduce microplastic exposure and its potential contribution to the growing allergy burden.
Effects of microplastics on allergic airways and potential pathogenesis: a review
This review examines how microplastics, which can enter the body through breathing, eating, and skin contact, may affect allergic airway conditions. Researchers found evidence that microplastics can damage airway lining cells, disrupt the protective barrier of the respiratory tract, and trigger heightened airway reactivity. The study suggests that chronic microplastic exposure may worsen allergic airway inflammation, though more research is needed to fully understand the mechanisms involved.
The Concept of One Health for Allergic Diseases and Asthma
This review examined how climate change, biodiversity loss, and environmental pollutants including microplastics contribute to rising allergic disease prevalence worldwide, advocating for a One Health approach that integrates human, animal, and ecosystem health strategies.
A Survey on Environmental Protective and Risk Factors and Awareness Related to Epithelial Barrier Integrity, Microbiome and Allergic Diseases
This study developed new questionnaires to assess environmental exposures — including microplastics, air pollutants, and detergents — that damage epithelial barriers and contribute to allergic diseases. The epithelial barrier theory links these exposures to microbial dysbiosis and the sharp rise in allergic, autoimmune, and neuropsychiatric conditions since the 1960s.
Theoretical and practical aspects of food allergy in the XXI century. EAACI 2021
This review synthesizes key discussions from the 2021 EAACI Congress on food allergy, covering environmental factors including microplastic contamination in food as a driver of allergic disease development, along with advances in biomarker identification, component diagnostics, and innovative treatments such as biological therapy and fecal microbiota transplantation.
Oral exposure to nano- and microplastics: Potential effects in food allergies?
This review explored whether exposure to nano- and microplastics through food could contribute to the rising rates of food allergies worldwide. Researchers found that these tiny plastic particles may alter the structure of food allergens, increase gut permeability, promote intestinal inflammation, and disrupt the immune system. While direct evidence is still limited, the study suggests that microplastics in the diet could potentially heighten sensitivity to food allergens.
Progress in understanding the impact of microplastics on respiratory allergic diseases
This review synthesized evidence on how airborne microplastics may affect respiratory allergic diseases such as allergic rhinitis and asthma. Researchers found that inhaled microplastics can compromise airway barriers by disrupting tight junctions, impairing mucus clearance, and weakening mucosal defenses. The study suggests that microplastic characteristics like polymer type, particle size, and surface chemistry influence how they initiate or worsen respiratory allergic responses.
Unraveling the impact of microplastics on autoimmune diseases: hidden dangers and environmental triggers
This review examines the emerging evidence linking microplastic exposure to the development and progression of autoimmune disorders. Researchers found that microplastics can modulate immune gene expression, trigger excessive reactive oxygen species in immune cells, and promote inflammatory cytokine release, potentially creating conditions favorable for autoantibody production. The study highlights microplastics as a plausible environmental trigger for autoimmune conditions, though direct causal evidence in humans remains limited.
Immune Disruption and Disease Development by Microplastic Exposure
This review synthesized growing evidence that microplastic and nanoplastic exposure disrupts the human immune system, covering how particles ingested, inhaled, or absorbed through skin can trigger inflammation, impair immune cell function, and potentially contribute to autoimmune and allergic conditions.
Microplastics in Allergic Rhinitis: Multimechanistic Drivers of Barrier Disruption and Immune Dysregulation
This review examines the multimechanistic pathways by which microplastics drive barrier disruption and immune dysregulation in allergic rhinitis, considering how physical and chemical properties of microplastic particles interact with nasal epithelial and immune function. The paper synthesizes emerging evidence on microplastics as a novel contributor to upper airway allergic disease.
Epithelial Barrier: Protector and Trigger of Allergic Disorders
This review explores the epithelial barrier hypothesis, which proposes that disruption of skin, lung, and gut epithelial barriers by environmental exposures such as microplastics and pollutants drives the rising incidence of allergic and inflammatory diseases.