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The Impact of Microplastics on Allergy: Current Status and Future Research Directions
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This study reviews current evidence on how microplastics may influence allergic responses, noting that microplastics can compromise epithelial barriers and promote type 2 inflammation associated with allergies. The authors emphasize an urgent need for research into dose-dependent immunotoxicological mechanisms to better understand the relationship between microplastic exposure and allergy development. The study calls for evidence-based policies to reduce microplastic exposure and its potential contribution to the growing allergy burden.
MPs compromise epithelial barriers and promote type 2 inflammation. There is an urgent need to elucidate dose-dependent immunotoxicological mechanisms. Evidence-based policies are required to mitigate exposure and allergy burden.
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Effects of microplastics on allergic airways and potential pathogenesis: a review
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This review examines how microplastics, which can enter the body through breathing, eating, and skin contact, may affect allergic airway conditions. Researchers found evidence that microplastics can damage airway lining cells, disrupt the protective barrier of the respiratory tract, and trigger heightened airway reactivity. The study suggests that chronic microplastic exposure may worsen allergic airway inflammation, though more research is needed to fully understand the mechanisms involved.
Airway exposure to microplastics: Potential mechanisms from epithelial barrier damage to the development of allergic rhinitis
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This review summarized the mechanisms by which airborne microplastic exposure triggers allergic rhinitis, identifying pathways including physical and chemical disruption of the airway epithelial barrier, oxidative stress from adsorbed pollutants, and induction of Th2 immune responses and IgE class-switching. The findings support airborne MPs as a novel trigger for upper respiratory allergic disease.
Progress in understanding the impact of microplastics on respiratory allergic diseases
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This review synthesized evidence on how airborne microplastics may affect respiratory allergic diseases such as allergic rhinitis and asthma. Researchers found that inhaled microplastics can compromise airway barriers by disrupting tight junctions, impairing mucus clearance, and weakening mucosal defenses. The study suggests that microplastic characteristics like polymer type, particle size, and surface chemistry influence how they initiate or worsen respiratory allergic responses.
Microplastics in Allergic Rhinitis: Multimechanistic Drivers of Barrier Disruption and Immune Dysregulation
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This review examines the multimechanistic pathways by which microplastics drive barrier disruption and immune dysregulation in allergic rhinitis, considering how physical and chemical properties of microplastic particles interact with nasal epithelial and immune function. The paper synthesizes emerging evidence on microplastics as a novel contributor to upper airway allergic disease.
Epithelial barrier dysfunction, type 2 immune response, and the development of chronic inflammatory diseases
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This review explains how everyday substances including microplastics, air pollutants, food additives, and household chemicals damage the protective lining of our body's surfaces (epithelial barriers). Even trace amounts of these substances can cause the barriers to become leaky, allowing bacteria and allergens to trigger chronic inflammation. The research suggests that microplastic exposure, alongside other modern pollutants, may be contributing to the rise in chronic inflammatory diseases over the past several decades.
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When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.