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61,005 resultsShowing papers similar to Effects of sn-2 Palmitic Triacylglycerols and the Ratio of OPL to OPO in Human Milk Fat Substitute on Metabolic Regulation in Sprague-Dawley Rats
ClearMicro problems with Macro Consequences: Accumulation of Persistent Organic Pollutants and Microplastics in Human Breast Milk and in Human Milk Substitutes
This review examines the co-occurrence of persistent organic pollutants (POPs) and microplastics in human breast milk and infant formula, highlighting that infants — one of the most vulnerable populations — may be exposed to both chemical and particle-based contaminants through feeding. The authors stress that the health effects of microplastic ingestion in early life remain largely unknown, making this a critical gap in understanding long-term developmental risks.
Isolating microplastics from human milk: a chemical digestion approach for effective polymer extraction and ATR-FTIR analysis
Researchers developed and evaluated a chemical digestion method for isolating microplastics from human breast milk, addressing the challenges posed by the high fat and protein content of this matrix. The method enabled ATR-FTIR polymer identification of MPs extracted from milk samples, providing a validated protocol for studying infant dietary MP exposure.
The cardiovascular toxicity of polystyrene microplastics in rats: based on untargeted metabolomics analysis
A rat study using metabolomics analysis found that long-term exposure to high concentrations of polystyrene microplastics led to abnormal fat metabolism and cardiovascular damage. The harm appeared to be driven by oxidative stress and inflammation, suggesting that chronic microplastic exposure could contribute to heart and blood vessel disease.
Effects of food contact material-related nanoplastics on 3T3-L1 cell uptake and lipid metabolism
Researchers examined the uptake of food contact material-derived nanoplastics into 3T3-L1 adipocyte cells and assessed subsequent effects on lipid metabolism. The study investigated how nanoplastics that migrate from packaging into food may disrupt fat storage and metabolic signaling at the cellular level.
Microplastics and Metabolism: Physiological Responses in Mice Following Ingestion
Researchers found that mice orally exposed to microplastic microspheres showed changes in lipid metabolism and other metabolic pathways, with particles detected in tissues throughout the body. The effects were more pronounced when mice were exposed to mixed microplastic types compared to polystyrene alone, suggesting that real-world mixtures of microplastics may have broader physiological impacts.
Association between exposure to microplastics and lipid disorders: A case-control study
Researchers conducted a case-control study examining the association between internal microplastic exposure and lipid metabolism disorders. The study found that microplastic exposure was significantly associated with lipid disorders, providing novel evidence that microplastics may adversely affect lipid metabolism in humans.
Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota
Researchers found that when mother mice ingested nanoplastics derived from polystyrene and polypropylene during pregnancy and nursing, their offspring showed increased body weight gain. The weight changes were associated with alterations in fat metabolism and shifts in gut microbiome composition in the pups. The study suggests that maternal exposure to nanoplastic pollution may act as an environmental factor contributing to weight gain in offspring.
Maternal Polystyrene Microplastic Exposure during Gestation and Lactation Altered Metabolic Homeostasis in the Dams and Their F1 and F2 Offspring
Researchers exposed pregnant mice to polystyrene microplastics during pregnancy and nursing and found significant metabolic disruptions in both the mothers and their offspring across two generations. The microplastics altered lipid metabolism, gut microbiota composition, and key metabolic signaling pathways. The study suggests that microplastic exposure during critical developmental windows may have lasting health consequences that pass to future generations.
Detection of Microplastics in Human Breast Milk and Its Association with Changes in Human Milk Bacterial Microbiota
Researchers detected microplastics in nearly 39% of breast milk samples from 59 mothers, with polypropylene and polyethylene being the most common types found. The presence of microplastics was linked to changes in the bacterial makeup of breast milk, raising concerns about early-life microplastic exposure in infants during breastfeeding.
Microplastic pollution: A potent threat for metabolic disruption in mammals
This review examines the evidence linking microplastic exposure to metabolic disruption, covering mechanisms by which microplastics and their associated chemical additives may interfere with hormonal regulation, glucose metabolism, and lipid homeostasis. The authors identify microplastics as a potent emerging threat to metabolic health.
Optimizing hexane, KOH, and H2O2 methods for lipid removal and organic matter digestion in microplastic analysis of human milk
Researchers developed and optimized a method for isolating microplastics from human breast milk, a particularly challenging sample due to its high fat and protein content. Using a combination of hexane for lipid removal and potassium hydroxide and hydrogen peroxide for organic matter digestion, they were able to successfully extract and identify microplastic particles. The study provides a validated analytical approach that could help future research assess infant exposure to microplastics through breastfeeding.
Microplastic-induced gut microbiota and serum metabolic disruption in Sprague-Dawley rats
Researchers exposed rats to a mixture of common microplastic types at concentrations reflecting real-world human exposure and found significant disruptions to gut bacteria and blood metabolites. The microplastic mixture altered the balance of beneficial and harmful gut microbes and changed metabolic pathways related to amino acids and lipids. The study suggests that everyday microplastic exposure from food and water may affect mammalian gut health and metabolism.
Human Milk, Microplastics and Children's Health: An Equation to Be Solved
This review examined microplastic contamination in human breast milk, summarizing evidence of widespread MP detection and discussing the potential health consequences for infants whose primary food source in the first two years of life may contain plastic particles.
Impact of polystyrene microplastic exposure on lipid profile and oxidative stress status of male and female Wistar rats
Researchers found that polystyrene microplastic exposure in Wistar rats caused significant alterations in lipid profiles and increased oxidative stress markers, with effects varying between male and female rats and between pristine polystyrene and Styrofoam forms.
Nano- and Microplastics Migration from Plastic Food Packaging into Dairy Products: Impact on Nutrient Digestion, Absorption, and Metabolism
This review examines how nano and microplastics migrate from plastic food packaging into dairy products like milk and infant formula. The plastic particles can interfere with how the body digests and absorbs proteins, fats, and carbohydrates, and may disrupt metabolism of lipids, glucose, and iron. These findings are especially concerning for infants and children who consume formula and milk from plastic containers, as their developing bodies may be more sensitive to these effects.
A metabolomics perspective on the effect of environmental micro and nanoplastics on living organisms: A review
This review examines how scientists use metabolomics, the study of small molecules produced by cellular processes, to understand the toxic effects of microplastics and nanoplastics on living organisms. The research shows that these plastic particles disrupt metabolism in consistent ways across species, affecting energy production, fat processing, and amino acid pathways. These shared metabolic disruptions across different organisms suggest that microplastics could cause similar metabolic problems in humans.
Micro problems with macro consequences: accumulation of persistent organic pollutants and microplastics in human breast milk and in human milk substitutes
This review examines the presence of persistent organic pollutants and microplastics in both human breast milk and infant formula, raising questions about early-life exposure. Researchers found that these contaminants can transfer to infants during the critical first 1,000 days of development, a period important for long-term health. The study highlights significant gaps in our understanding of how combined exposure to microplastics and organic pollutants during infancy may affect health outcomes.
Are microplastics in food a risk factor for obesity: Current evidence, mechanistic pathways and emerging health risks associated with human exposure
This review examines the emerging evidence linking microplastic and nanoplastic exposure to metabolic dysfunction and potential obesity risk. Researchers found that these particles have been detected in multiple human tissues and may contribute to inflammation, hormonal disruption, gut microbiome changes, and altered fat cell development. While animal and laboratory studies support a plausible connection, the study notes that direct evidence in humans is still limited and further research is needed.
Editorial: Role of hormones and bioactive components in breast milk on development of metabolic, neural and behavioral systems in offspring
This editorial introduces research on how hormones and bioactive compounds in breast milk shape the metabolic, neural, and behavioral development of offspring. Breast milk has been found to contain microplastics, raising questions about whether plastic particles may also affect the developmental role of this critical early food source.
Human Milk—The Biofluid That Nourishes Infants from the First Day of Life
This review highlights that human breast milk, while being the ideal nutrition for infants, is now subject to contamination by environmental pollutants including microplastics. The presence of microplastics in breast milk means that infants may be exposed to plastic particles from the very first days of life. The authors call for new monitoring methods to better understand the extent of contamination and its potential effects on infant development.
Long-Term Exposure to Environmentally Relevant Doses of Large Polystyrene Microplastics Disturbs Lipid Homeostasis via Bowel Function Interference
Researchers exposed mice to environmentally relevant doses of large polystyrene microplastics in their diet for 21 weeks and found significant disruptions to fat metabolism and gut bacterial communities. The microplastics interfered with bowel function, which in turn altered how the body processes and stores lipids. The study provides evidence that even low-level, long-term microplastic exposure through food may affect metabolic health in mammals.
Biological exposure to microplastics and nanoplastics and plastic additives: impairment of glycolipid metabolism and adverse effects on metabolic diseases
This review examines how exposure to micro- and nanoplastics disrupts the body's ability to process sugars and fats, potentially contributing to diabetes, obesity, and atherosclerosis. The plastics cause inflammation and oxidative stress, damage gut bacteria, trigger insulin resistance, and increase fat buildup in the liver. For people who already have metabolic conditions, plastic exposure may make their disease worse.
Untargeted lipidomics uncover hepatic lipid signatures induced by long-term exposure to polystyrene microplastics in vivo
Researchers exposed rats to polystyrene microplastics over 6 and 12 months and used advanced lipid profiling to assess liver damage. They found that long-term exposure caused liver inflammation, fatty liver changes, and significant alterations in eight key lipid metabolites involved in fat processing. The study provides evidence that chronic microplastic exposure can disrupt liver lipid metabolism, raising concerns about long-term health effects.
Microplastics Contamination in Breast Milk and Infant Milk Products in Indonesia
Researchers measured microplastic contamination in breast milk and infant formula products in Indonesia and found that powdered formula had the highest average particle count, followed by liquid formula, stored breast milk, and fresh breast milk. Notably, 37% of fresh breast milk samples had no detectable microplastics. The findings raise concerns about infant exposure to microplastics through both breast milk and formula, with packaging and processing appearing to increase contamination levels.