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20 resultsShowing papers similar to Interactions between intestinal microbiota and metabolites in zebrafish larvae exposed to polystyrene nanoplastics: Implications for intestinal health and glycolipid metabolism
ClearImpacts of polystyrene nanoplastics on zebrafish gut microbiota and mechanistic insights
Zebrafish exposed to polystyrene nanoplastics showed significant changes in their gut bacteria, with beneficial species like Bifidobacterium declining and potentially harmful bacteria increasing. The nanoplastics physically entered intestinal tissues, causing visible damage to gut cells. This study is relevant to human health because our gut microbiome plays a key role in immunity and digestion, and similar disruption from nanoplastic exposure could contribute to digestive and immune problems.
Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish
Researchers exposed zebrafish to polystyrene microplastics for 21 days and found significant intestinal inflammation, oxidative stress, and disruption of both the gut microbiome and metabolic processes. The microplastics altered the balance of beneficial and harmful gut bacteria and changed the levels of key metabolites involved in energy and amino acid metabolism. The study provides detailed evidence that microplastic ingestion can cause widespread disruption to gut health in aquatic organisms.
Polystyrene nanoplastics-induced intestinal barrier disruption via inflammation and apoptosis in zebrafish larvae (Danio Rerio)
Zebrafish larvae exposed to polystyrene nanoplastics showed significant gut damage, including increased cell death, inflammation, and breakdown of the intestinal barrier. The nanoplastics accumulated in the digestive tract and triggered chemical changes that suggest the plastic particles interact with biological tissue. Since zebrafish share many genetic similarities with humans, these findings raise concerns that nanoplastic ingestion could damage the human gut lining.
Toxicity of Polystyrene Nanoplastics in the Liver and Intestine of Normal and High-Fat-Diet Juvenile Zebrafish
Researchers exposed juvenile zebrafish to polystyrene nanoplastics combined with a high-fat diet and found that the combination caused gastrointestinal injury and disrupted lipid metabolism. The nanoplastics alone perturbed gut microbiota stability, and the effects were amplified when paired with a high-fat diet. The study suggests that dietary factors may influence the severity of nanoplastic toxicity, highlighting the importance of considering real-world exposure scenarios.
Effects of polystyrene microplastics on the composition of the microbiome and metabolism in larval zebrafish
Researchers exposed larval zebrafish to two sizes of polystyrene microplastics and found significant changes in gut microbiome composition and metabolic activity. The microplastics altered the abundance and diversity of gut bacteria and disrupted metabolic pathways important for development. The study suggests that early-life exposure to microplastics could have meaningful biological consequences by reshaping the gut environment of developing organisms.
Polystyrene nano/microplastics induce microbiota dysbiosis, oxidative damage, and innate immune disruption in zebrafish
Researchers exposed zebrafish to polystyrene particles of two different sizes and found that both nano- and micro-sized plastics disrupted gut bacteria, caused oxidative damage, and altered immune responses. The severity of effects depended on particle size and concentration, with smaller particles and higher doses causing more harm. The study suggests that plastic particles in waterways may pose a broader threat to fish health than previously understood, affecting digestion, stress defenses, and immunity simultaneously.
Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish
Researchers exposed adult zebrafish to polystyrene microplastics of two different sizes for 14 days and found significant disruptions to the gut microbiome, including shifts in key bacterial populations. Smaller microplastic particles also triggered inflammatory responses in the gut, with elevated levels of inflammatory markers at both the gene and protein level. The study suggests that microplastic ingestion can disturb gut bacteria balance and cause intestinal inflammation in aquatic organisms.
Effect of polystyrene nanoplastics on the intestinal histopathology, oxidative stress, and microbiota of Acrossocheilus yunnanensis
Researchers studied the effects of polystyrene nanoplastics on the intestinal health of a freshwater fish species and found significant damage to the gut lining, including ruptured tissue and damaged nutrient-absorbing structures. The nanoplastics also increased oxidative stress markers and shifted the composition of gut bacteria, reducing beneficial species. The findings suggest that nanoplastic exposure can compromise both the physical barrier and microbial balance of fish intestines.
Oral exposure to high concentrations of polystyrene microplastics alters the intestinal environment and metabolic outcomes in mice
In a mouse study, oral exposure to high concentrations of polystyrene microplastics caused fatty liver disease and abnormal blood lipid levels even without prior gut leakiness. The microplastics triggered intestinal inflammation through immune cells, disrupted gut bacteria, and altered how the body processes nutrients. These results suggest that swallowing microplastics could contribute to metabolic problems and liver disease in humans.
Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health
Zebrafish exposed to polystyrene nanoparticles for 28 days showed significant disruptions in liver metabolism, including altered fat processing, signs of inflammation, oxidative stress, and DNA damage. Notably, at lower doses the liver's detox enzymes appeared to break down the nanoplastics themselves, while higher doses overwhelmed these defenses and caused more severe injury.
Comparison of metabolome profiles in zebrafish (Danio rerio) intestine induced by polystyrene microplastics with different sizes
Researchers compared metabolic profiles in zebrafish intestines after exposure to polystyrene microplastics of different sizes, finding that smaller particles caused more severe metabolic disruption including altered lipid metabolism and amino acid pathways in a size-dependent manner.
Polystyrene nanoplastics disrupt the intestinal microenvironment by altering bacteria-host interactions through extracellular vesicle-delivered microRNAs
Researchers found that polystyrene nanoplastics disrupt the gut lining in mice by altering tiny RNA molecules that control the production of protective proteins in the intestinal barrier. The nanoplastics also caused an imbalance in gut bacteria, creating a chain reaction where damaged gut cells release particles that further weaken the intestinal barrier and change the microbiome.
Study of the effects of nanoplastics ingestion in a freshwater fish ( Danio rerio )
Researchers exposed zebrafish to polystyrene nanoplastics and found evidence of intestinal damage, oxidative stress, and behavioral changes. The study adds to growing evidence that nanoplastics in freshwater environments can harm fish health, with potential implications for the health of ecosystems and fish-eating humans.
Polystyrene Nanoplastics Toxicity to Zebrafish: Dysregulation of the Brain–Intestine–Microbiota Axis
This study found that polystyrene nanoplastics disrupted the brain-gut connection in zebrafish at environmentally realistic concentrations, affecting growth, gut health, and brain chemistry. The nanoplastics altered neurotransmitter levels, particularly reducing a dopamine-related compound, and changed the balance of gut bacteria in ways that correlated with brain changes. These findings suggest a pathway by which nanoplastics in food and water could affect both digestive and brain health through the gut-brain axis.
Effects of polystyrene nanoplastics on apoptosis, digestive enzymes, and intestinal histological structure and flora of swamp eel (Monopterus albus)
Researchers exposed swamp eels (Monopterus albus) to polystyrene nanoplastics and found inflammation in the liver and intestine, significant gene expression changes in the liver, and shifts in intestinal microbial community composition toward more pathogenic taxa. The results demonstrate that nanoplastic exposure disrupts apoptosis pathways, digestive enzyme activity, and gut microbiome health in this freshwater fish.
Polystyrene microplastics induce endoplasmic reticulum stress, apoptosis and inflammation by disrupting the gut microbiota in carp intestines
Researchers fed carp polystyrene microplastics and found that the particles disrupted their gut bacteria, killing off beneficial species and promoting those linked to diseases. The microplastics triggered a stress response in intestinal cells that led to inflammation, cell death, and tissue damage. Since carp is a widely eaten fish, these gut health effects raise questions about how microplastics in aquatic environments could affect the safety of fish that humans consume.
Negative impact of oral exposure to polystyrene microplastics on glucose tolerance and intestinal environment in mice is independent of particle size
Researchers fed mice on a high-fat diet polystyrene microplastics of three different sizes and found that all sizes impaired glucose tolerance, regardless of particle dimensions. The microplastics caused intestinal inflammation, altered gut bacteria, and damaged the lining of the intestinal tract. The study suggests that the harmful metabolic effects of ingesting microplastics may occur broadly and are not limited to one particular particle size.
Effects of polystyrene nanoplastics on oxidative stress, histopathology and intestinal microbiota in largemouth bass (Micropterus salmoides)
Researchers exposed largemouth bass — a commercially important freshwater fish — to polystyrene nanoplastics (tiny plastic particles 100 nanometers in size) for up to 19 days, finding tissue damage in the gills, liver, and intestines along with elevated markers of cellular stress. While growth was not significantly affected, the fish adjusted their gut microbiome in response, suggesting nanoplastics trigger adaptive but potentially harmful physiological changes.
Nanoplastics impair the intestinal health of the juvenile large yellow croaker Larimichthys crocea
Researchers exposed juvenile large yellow croaker fish to nano-sized polystyrene particles to assess impacts on intestinal health and growth. The study found that nanoplastics accumulated in the fish and caused disorders in digestion, antioxidant defenses, immune function, and intestinal microflora, indicating that nanoplastics can significantly impair gut health in commercially important marine fish species.
Lipid-Rich diet protects aquatic vertebrates by reducing polystyrene nanoparticles deposition and alleviating harmful effects from exposure
Researchers showed in zebrafish that polystyrene nanoplastics accumulate selectively in a narrow intestinal segment and alter immune and lipid metabolism gene expression, and that a lipid-rich diet significantly reduced intestinal nanoplastic deposition and partially restored normal transcriptomic profiles.