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61,005 resultsShowing papers similar to Neurotoxicity of Some Environmental Pollutants to Zebrafish
ClearEffects of Microplastics and Nanoplastics on Neurodevelopment and Neurodegeneration in Zebrafish
This review covers how micro- and nanoplastic (MNP) exposure affects neurodevelopment and neurodegeneration in zebrafish, summarising evidence on impaired neurodevelopment, behavioural changes, and markers of neurodegeneration from studies using various polymer types and exposure routes. It frames zebrafish as a key model for understanding MNP neurotoxicity.
A review on the impacts of nanomaterials on neuromodulation and neurological dysfunction using a zebrafish animal model
This review assessed zebrafish as a model for studying nanomaterial neurotoxicity, summarizing evidence that various engineered nanoparticles including those associated with plastics can impair zebrafish neural development, behavior, and neurotransmitter systems. The authors highlighted zebrafish as particularly useful for rapid in vivo screening of nanomaterial neurological effects.
From particle size to brain function: a zebrafish-based review of micro/nanoplastic-induced neurobehavioral toxicity and mechanistic pathways
This review uses zebrafish as a model to examine how micro- and nanoplastics cause neurobehavioral toxicity, linking particle size to brain function disruption. Researchers summarize evidence that these plastic particles impair fish behavior and cause molecular-level damage in the nervous system. The findings highlight the growing concern that micro- and nanoplastics are emerging neurotoxicants in aquatic environments.
Temperature- and chemical-induced neurotoxicity in zebrafish
This review examines how zebrafish are used as a model organism to study the neurotoxic effects of chemicals including heavy metals, pesticides, and plastic additives. Researchers found that zebrafish allow analysis across all developmental stages using advanced molecular and behavioral tools, making them valuable for understanding how toxic substances damage the nervous system. The study also highlights that temperature fluctuations, not just chemical exposure, can trigger neurotoxic responses.
Research progress of model animal zebrafish in toxicity evaluation of microplastics
This review examines the use of zebrafish as a model organism for evaluating the toxicity of microplastics, synthesizing research on how microplastic exposure affects development, reproduction, and physiological function in this well-established vertebrate model. The authors highlight zebrafish as a particularly valuable system for mechanistic toxicology studies given its genetic tractability and the breadth of endpoints assessable across life stages.
Research Progress of Zebrafish Model in Aquatic Ecotoxicology
This review examines how zebrafish are used as model organisms to study the toxic effects of environmental pollutants in water, including microplastics. Zebrafish are ideal because they reproduce quickly, are inexpensive to maintain, and allow researchers to study effects at the genetic, cellular, and whole-organism level. The paper provides a reference guide for scientists choosing model animals for aquatic toxicology research.
Comprehensive review of ecological risks and toxicity mechanisms of microplastics in freshwater: Focus on zebrafish as a model organism
This comprehensive review examines how microplastics affect zebrafish, a widely used laboratory model, covering impacts on the gut, liver, reproductive system, nervous system, and immune function. Researchers found that microplastics can cause oxidative stress, inflammation, and disruption of gut bacteria across multiple organ systems. The review highlights that zebrafish studies provide valuable insights into the biological mechanisms by which microplastics may affect freshwater organisms and, potentially, human health.
Advantages of the zebrafish (Danio rerio) model in solving contemporary problems of neurotoxicity, teratotoxicity and genotoxicity of xenobiotics
This paper is not about microplastics per se; it is a Polish-language review of the zebrafish (Danio rerio) model in toxicology, covering its use for assessing neurotoxicity, teratotoxicity, and genotoxicity of xenobiotics including nanoparticles and microplastics, with discussion of the micronucleus and comet assays used to detect genetic damage.
Do Microplastics Have Neurological Implications in Relation to Schizophrenia Zebrafish Models? A Brain Immunohistochemistry, Neurotoxicity Assessment, and Oxidative Stress Analysis
Zebrafish exposed to microplastics showed increased brain damage and oxidative stress, especially when combined with chemicals that mimic schizophrenia-related conditions. The study suggests microplastics may worsen neurological problems by interacting with other brain-altering substances, highlighting potential concerns about how plastic pollution could contribute to neuropsychiatric disorders.
Abamectin Causes Neurotoxicity in Zebrafish Embryos
This study found that abamectin, a widely used agricultural pesticide, caused brain damage and nerve cell death in developing zebrafish embryos through oxidative stress. While not about microplastics, the research is relevant because microplastics can absorb and transport pesticides like abamectin through water systems, potentially delivering concentrated doses to aquatic organisms. Understanding pesticide neurotoxicity helps explain how chemical-laden microplastics could harm both wildlife and human nervous system development.
Nanoplastics in the Environment and the Effects on the Zebrafish
This study reviewed the effects of nanoplastic exposure on zebrafish, covering how these tiny particles affect development, organ function, behavior, and reproductive success. Zebrafish are a widely used model organism for toxicology, and findings in this species provide insight into potential effects in other vertebrates including humans.
A current perspective on the relevance of nano and microplastics in the neurodevelopmental disorders: further relevance for metabolic, gastrointestinal, oxidative stress-related and zebrafish studies
This review examines evidence that micro- and nanoplastics may affect brain development and neurological function, drawing on studies in zebrafish and other animal models. The authors discuss potential mechanisms including oxidative stress and endocrine disruption, and call for more research on the neurodevelopmental risks of plastic particle exposure.
Advances of microplastics ingestion on the morphological and behavioral conditions of model zebrafish: A review
This review summarizes research on how microplastic ingestion affects zebrafish, a popular lab animal that shares genetic similarities with humans. Studies show that microplastics cause a range of harmful effects in zebrafish, including abnormal behavior, oxidative stress, immune disruption, and reproductive problems, with smaller particles and higher concentrations causing the most damage. Since zebrafish are used as a model for human health, these findings raise concerns about what similar exposure levels could mean for people.
In vivo biotoxicological assessment of nanoplastics and microplastics predicted using the zebrafish model
This review summarises zebrafish studies on the toxicity of nanoplastics and microplastics, covering developmental, reproductive, neurological, and organ-level effects. It discusses how findings in this widely used model organism may predict human health outcomes and calls for standardised exposure protocols.
Zebrafish Insights into Nanomaterial Toxicity: A Focused Exploration on Metallic, Metal Oxide, Semiconductor, and Mixed-Metal Nanoparticles
This review summarizes research on how various nanomaterials, including nano-sized plastics, affect zebrafish, which are commonly used as stand-ins for studying human health effects. Exposure to nanomaterials caused developmental defects, organ damage, behavioral changes, and reproductive problems in zebrafish. These findings help scientists understand the potential health risks of nanomaterial exposure to humans and the environment.
Effects of microplastics on the accumulation and neurotoxicity of methylmercury in zebrafish larvae
Researchers found that microplastics can adsorb methylmercury and act as carriers, increasing its accumulation in zebrafish larvae and worsening neurotoxicity by disrupting locomotor activity and triggering oxidative stress.
Neurotoxicity of Plastics: Mechanistic Insights into the Progression of Neurodegenerative Diseases in Animal Models
This review summarizes evidence from rodent and zebrafish studies showing that plastic-derived chemicals — including BPA, phthalates, and micro/nanoplastics — penetrate or impair the blood-brain barrier and trigger oxidative stress, neuroinflammation, and neurodegeneration.
Zebrafish: An emerging model to study microplastic and nanoplastic toxicity
This review highlights zebrafish as an increasingly valuable model organism for studying the toxic effects of micro- and nanoplastics due to their transparent embryos, genetic similarity to humans, and ease of laboratory use. Researchers summarized existing zebrafish studies showing that plastic particles can cross biological barriers and accumulate in tissues, causing various toxic effects. The study positions zebrafish research as a key tool for advancing our understanding of how plastic particle exposure affects living organisms.
Zebrafish as Model Organism in Aquatic Ecotoxicology: Current Trends and Future Perspectives
This review assessed zebrafish as model organisms for aquatic ecotoxicology, summarizing current trends and future directions in using Danio rerio to study the effects of environmental pollutants including microplastics. The authors highlight the zebrafish model's utility for integrating molecular, cellular, and whole-organism responses.
O Modelo Zebrafish e sua Contribuição ao Meio Ambiente
This Brazilian review examined zebrafish as a model organism for testing water quality and the toxicity of micropollutants including microplastics in wastewater. Zebrafish are increasingly used as a standard test system for evaluating the biological effects of microplastic exposure because their genetics and physiology closely mirror human responses.
Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos
This review summarizes research on how micro- and nanoplastics harm embryo development using zebrafish as a model organism that shares genetic similarities with humans. Studies show these tiny plastic particles cause damage to the brain, heart, gut, and immune system of developing embryos, largely through oxidative stress and cell death pathways.
Effects of pristine or contaminated polyethylene microplastics on zebrafish development
Researchers examined the effects of both pristine and pollutant-contaminated polyethylene microplastics on zebrafish development through chronic exposure. The study assessed how microplastics, both alone and as carriers of adsorbed organic pollutants, affect developing fish. The findings provide new insights into how contaminated microplastics may create additional routes for toxic compounds to enter aquatic food webs.
Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment
This review examines how nano- and micro-sized plastic particles cause toxic effects in zebrafish, focusing on the link between oxidative stress and neurodevelopmental damage. Researchers found that plastic particle exposure disrupts the balance of reactive oxygen species in cells, which can impair brain development and nervous system function. The study suggests these oxidative stress responses may serve as early warning signals of plastic particle toxicity in aquatic organisms.
The Zebrafish as an Alternative Animal Model for Ecotoxicological Research and Testing
This review highlights zebrafish as a valuable model for studying the toxic effects of environmental contaminants, including microplastics, because they share many biological pathways with humans. Zebrafish embryos, larvae, and adults can be used to screen for harmful effects of pollutants quickly and at multiple life stages. The approach helps researchers understand how microplastics and other environmental contaminants might affect human health without requiring direct human testing.