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Papers
20 resultsShowing papers similar to The concept of balance in microbiome research
ClearThe virtual microbiome: A computational framework to evaluate microbiome analyses
Researchers created virtual bacterial populations mimicking real microbiome ecology to test the accuracy of standard microbiome analysis pipelines, finding that gaps in genomic databases significantly compromise microbiome characterization reliability — an issue typically overlooked in microbiome studies.
Improving the assessment of ecosystem and wildlife health: microbiome as an early indicator
Researchers reviewed evidence that the microbiome — the community of microorganisms living in environments and within animals — can serve as an early warning system for ecosystem disturbance, rapidly reflecting the impact of human activities before other signs of harm are visible.
Microbiome differential abundance methods produce different results across 38 datasets
Researchers compared 14 commonly used methods for identifying differentially abundant microbes across 38 microbiome datasets. They found that different methods often produced substantially different results when applied to the same data, with high rates of disagreement between tools. The study highlights that the choice of analytical method can significantly influence microbiome research conclusions and calls for greater standardization in the field.
Microplastics in Humans: A Critical Review of Biomonitoring Evidence and Immune–Metabolic Associations
This review critically evaluates the current evidence on microplastic detection in human tissues and biological fluids, focusing on methodological challenges and the potential biological mechanisms of action. Researchers found significant variation across studies due to differences in analytical techniques and sample handling protocols. The study highlights emerging evidence linking microplastic presence in the body to immune and metabolic disruptions, while noting that standardized detection methods are urgently needed.
How do microplastics affect the composition and function of gut microbiota?
Researchers reviewed how microplastics may disrupt gut microbiota composition and metabolic function, noting that while dysbiosis is a likely outcome of exposure, the full extent of these effects in humans remains poorly characterized and understudied.
The urgent need for microbiology literacy in society
This paper argues that society urgently needs better microbiology literacy to make informed decisions about issues ranging from public health to environmental management. Researchers highlight that microbes underpin critical functions in ecosystems, human health, and the biosphere, yet public understanding of microbiology remains extremely limited. The study calls for integrating microbiology education into broader scientific literacy efforts to help individuals and policymakers make better evidence-based decisions.
The Footprint of Microbiome in Pediatric Asthma—A Complex Puzzle for a Balanced Development
This review examines the growing body of evidence linking the human microbiome to the development of pediatric asthma. Researchers found that the composition of bacteria in the gut and respiratory tract during early childhood appears to influence whether children develop asthma. The study suggests that understanding these microbial patterns could open new approaches for preventing or managing asthma in children.
How do microplastics affect the composition and function of gut microbiota?
Researchers reviewed how microplastics may disrupt gut microbiota composition and metabolic function, noting that while dysbiosis is a likely outcome of exposure, the full scope of these effects in humans remains understudied.
Microplastics in food - a critical approach to definition, sample preparation, and characterisation
This review critically examines how microplastics in food are defined, extracted, and analyzed across different studies, finding significant inconsistencies that make it hard to compare results. The lack of standardized methods for isolating and identifying microplastics in food means that contamination levels may be over- or underestimated. The authors call for unified research methods to enable credible assessments of how dietary microplastic exposure affects health.
Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
This Mendelian randomization study found genetic evidence supporting a causal relationship between specific gut microbiota compositions and gastrointestinal diseases. The findings suggest that microbiome-related interventions, including microbiome-dependent metabolites, could potentially be developed to treat or manage gastrointestinal conditions.
Symbiotoxicity: The Ability of Environmental Stressors to Damage Healthy Microbiome Structure and Interactions with the Host
This review proposes the concept of symbiotoxicity to describe how environmental stressors including microplastics, chemicals, and pathogens can disrupt healthy host-microbiome interactions, arguing that damage to the microbiome should be considered a distinct endpoint in ecological risk assessment.
Microbiome: A forgotten target of environmental micro(nano)plastics?
This review examines how micro- and nanoplastics affect the microbiome of various organisms, an area that has received less attention than other toxicological endpoints. Researchers found that most studies focused on polystyrene particles and that exposure consistently disrupted microbiome composition, triggered immune responses, and altered enzyme activity across organisms including crustaceans, fish, and mammals. The study highlights the microbiome as an important but often overlooked target of microplastic pollution.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Nexus Between Sarcopenia and Microbiome Research: A Bibliometric Exploration
Researchers conducted a bibliometric analysis of the intersection between sarcopenia and microbiome research, analyzing 997 articles from the Science Citation Index Extended Database to map scientific production, international collaboration networks, and emerging research hotspots in this growing field.
Microplastics and their interactions with microbiota
This review examines how microplastics interact with microbiota (the communities of microorganisms in the environment and in living bodies). Microplastics can carry harmful bacteria and disrupt the natural balance of microbial communities in soil, water, and the human gut. The disruption of gut microbiota by microplastics is particularly concerning because a healthy gut microbiome is essential for immune function, digestion, and overall health.
Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics
This bibliometric analysis mapped global research trends and hotspots in gastrointestinal microbiome and toxicity studies, finding that modifications to the gut microbiome could offer new directions for treating and mitigating toxic exposures.
The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?
This review examines the human archaeome—archaeal microorganisms inhabiting the gut, skin, and other body sites—and their potential roles in health and disease. It finds no conclusive archaeal pathogens in humans but identifies indirect roles through metabolic interactions with bacteria, relevant to gut microbiome research.
Microplastics: Finding a consensus on the definition
This paper reviewed the history and inconsistencies in microplastic definitions across the scientific literature and proposed a new comprehensive definition incorporating size, origin, material composition, and physical state. The proposed definition aims to resolve ambiguities that have led to non-comparable data across studies and hinder regulatory decision-making.
Editorial: Probiotics for global health: advances, applications and challenges
This editorial synthesizes recent advances in probiotic research for global health applications, highlighting their potential to support host health, prevent disease, and counteract dysbiosis, while identifying key challenges in making safe and sustainable probiotic interventions more accessible.
Editorial: Probiotics for global health: advances, applications and challenges
This editorial review summarizes recent advances in probiotic research, covering their health benefits, applications in disease prevention, and challenges in scaling safe and effective probiotic interventions. The piece highlights probiotics as a promising complement to conventional therapies given the global burden of dysbiosis-related diseases.