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Papers
20 resultsShowing papers similar to Microplastics and the gut-brain axis: Unraveling neurotoxic mechanisms and health implications
ClearNanoplastic Impact on the Gut-Brain Axis: Current Knowledge and Future Directions
Researchers reviewed the emerging evidence on how nanoplastics may affect the gut-brain axis, the communication pathway between the digestive and nervous systems. Studies indicate that nanoplastic exposure can alter gut microbiota, increase intestinal permeability, trigger oxidative stress and inflammation, and produce neurotoxic and behavioral effects. The review calls for more research given the ubiquitous presence of plastics in the human environment and the potential for nanoplastics to disrupt this critical biological communication pathway.
Innovative mechanisms of micro- and nanoplastic-induced brain injury: Emphasis on the microbiota-gut-brain axis
This review summarizes how micro- and nanoplastics may damage the brain through the gut-brain axis, a communication pathway between the digestive system and the nervous system. Nanoplastics can disrupt gut bacteria and weaken the intestinal barrier, potentially sending inflammatory signals to the brain. The authors suggest that targeting gut health could be a way to reduce brain damage caused by nanoplastic exposure.
Neurotoxicity of Micro- and Nanoplastics: A Comprehensive Review of Central Nervous System Impacts
This comprehensive review summarizes the evidence linking micro- and nanoplastic exposure to damage in the brain and nervous system. The plastics can harm neurons, disrupt the protective blood-brain barrier, trigger brain inflammation, and promote the clumping of proteins associated with diseases like Alzheimer's. The review highlights the gut-brain axis as a key pathway, meaning microplastics swallowed in food and water could affect brain health through the digestive system.
Health risk analysis of micro-and nanoplastic exposure via the microbiota-gut-brain axis
This review examines how micro- and nanoplastics that accumulate in the gastrointestinal tract may disrupt the microbiota-gut-brain axis through neural, immune, and endocrine pathways. The study suggests that these particles can interfere with normal gut microbiota function after entering the body through diet, inhalation, and skin contact, potentially inducing or worsening health effects.
Molecular insights into physiological impact of micro- and nano-plastics on the digestive system and gut-brain axis
This review evaluates molecular-level evidence on how micro- and nanoplastics affect the digestive system and the gut-brain axis after ingestion through contaminated food and water. The study describes how these particles accumulate in the gastrointestinal tract, liver, and pancreas, causing oxidative stress, gut microbiota disruption, and compromised intestinal barriers, potentially allowing particles to reach the central nervous system and contribute to neuroinflammatory conditions.
Probiotics an emerging therapeutic approach towards gut-brain-axis oriented chronic health issues induced by microplastics: A comprehensive review
This review examines how microplastics disrupt the gut-brain axis, the communication system between the digestive system and the brain, leading to chronic health problems like inflammation and neurological issues. The authors highlight probiotics as a promising treatment approach, since beneficial bacteria can help repair gut damage caused by microplastic exposure. The findings suggest that supporting gut health through probiotics may help counteract some of the harmful effects of microplastics on both digestion and brain function.
Mechanistic insight of neurodegeneration due to micro/nano-plastic-induced gut dysbiosis.
This review provided mechanistic insight into how micro/nano-plastic-induced gut dysbiosis drives neurodegeneration, tracing a pathway from intestinal microbiome disruption to neuroinflammation and brain damage. It identified the gut-brain axis as the critical link between plastic particle exposure and progressive neurodegenerative conditions.
Impact of micro- and nanoplastics exposure on human health: focus on neurological effects from ingestion
This review compiles emerging evidence on how ingested microplastics and nanoplastics may affect the brain and nervous system. Researchers found that these particles can disrupt gut bacteria, cross the blood-brain barrier, and accumulate in neural tissue, potentially triggering inflammation, oxidative stress, and protein changes linked to cognitive problems. The study highlights an urgent need for more human research, as initial findings have associated elevated plastic particle levels in brain tissue with neurological concerns.
From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk
This review examines evidence that microplastics may affect neurovascular health through the gut-brain axis, potentially contributing to stroke risk factors. Researchers found that animal and in vitro studies suggest microplastics can disrupt gut barrier integrity, trigger systemic inflammation, and impair blood-brain barrier function, though the authors note that direct causal links in humans remain unestablished.
Gut microbiota as an emerging target for the health implications of microplastics
This review examines how microplastic exposure disrupts the gut microbiome, finding evidence that microplastics damage intestinal barrier proteins, promote inflammation and oxidative stress, and may drive systemic effects including neurotoxicity and reproductive toxicity through gut-mediated pathways.
From environment to brain: the role of microplastics in neurobehavioral disorders
This review examines how microplastics enter the human body and cross the blood-brain barrier, linking their presence in neural tissue to neurobehavioral disorders through mechanisms including neuroinflammation, oxidative stress, and disruption of neurotransmitter systems.
Mind over Microplastics: Exploring Microplastic-Induced Gut Disruption and Gut-Brain-Axis Consequences
This review explores how microplastics, which contaminate drinking water and many common foods, may disrupt the gut and trigger inflammation that affects the brain through the gut-brain connection. The evidence suggests that microplastics could be contributing to the rising rates of brain diseases like Alzheimer's and Parkinson's, though more research in humans is needed to confirm this link.
Microplastics and human health: unveiling the gut microbiome disruption and chronic disease risks
This review summarizes evidence that microplastics disrupt the gut microbiome, the community of bacteria in our digestive system that plays a key role in immunity, metabolism, and overall health. By altering gut bacteria balance and triggering inflammation, microplastic exposure may contribute to chronic conditions including inflammatory bowel disease, metabolic disorders, and potentially even neurological problems through the gut-brain connection.
Deciphering the Neurotoxic Burden of Micro- and Nanoplastics: From Multi-model Experimental Evidence to Therapeutic Innovation
This review summarizes research on how micro- and nanoplastics damage the brain and nervous system, covering evidence from cell studies, animal experiments, and clinical observations. Plastic particles can cross the blood-brain barrier, disrupt the gut-brain connection, cause oxidative stress, and trigger inflammation that leads to memory problems and cognitive decline. The review also discusses potential treatment strategies, making it a useful resource for understanding the brain health risks of plastic exposure.
Breaching Barriers: Microplastic Translocation into Human Body Through Food and Implications for Neurodegeneration
This systematic review traced how microplastics enter the body through food and potentially reach the brain. Once ingested, these particles can cross the gut barrier, enter the bloodstream, and accumulate in brain tissue, where they may cause oxidative stress and inflammation that could contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Effects of Microplastics on Mental Health
This review examines the emerging evidence linking microplastic exposure to mental health outcomes, discussing proposed mechanisms including neuroinflammation, gut-brain axis disruption, and endocrine interference from plastic-associated chemicals. The authors call for dedicated human cohort studies to establish whether environmental microplastic levels contribute to psychiatric or cognitive conditions.
Environmental exposure pathways of microplastics and their toxic effects on ecosystems and the nervous system
This review examines the environmental pathways by which microplastics enter the human body through ingestion, inhalation, and skin contact, with a particular focus on their effects on the nervous system. Researchers summarize evidence that microplastics can cross the blood-brain barrier and may trigger neuroinflammation and oxidative stress in brain tissue. The study highlights the nervous system as a key area of concern for microplastic-related health research.
An overview of research on the association between microplastics and central nervous system disorders
This review explores the growing body of evidence linking microplastic exposure to central nervous system disorders. Researchers found that microplastics can enter the body through ingestion, inhalation, and skin absorption, then accumulate in neural tissues where they trigger inflammation, oxidative stress, and neuronal damage. The study aims to provide a scientific foundation for assessing the public health risks of microplastic exposure on brain health.
Microplastic: Characteristics, exposure pathways, toxicity, and implication for human health
This review examines how microplastics enter the human body through food, water, air, and skin contact, and the potential health effects of that exposure. Researchers found associations between microplastic exposure and issues such as gut inflammation and disrupted neurotransmitter levels, with particles even detected in human brain tissue. The study highlights the urgent need for better regulations, improved recycling, and new removal technologies to reduce microplastic-related health risks.
Assessing the Impact of Microplastics on Brain Chemistry: The Need for a Comprehensive Policy Framework to Mitigate Toxicity
This review examines the growing evidence that microplastics can cross biological barriers, accumulate in brain tissue, and affect neurological function. Researchers found that microplastic exposure has been linked to neurotoxicity, oxidative stress, and inflammation in the brain, with potential implications for neurotransmitter systems and cognitive function. The study calls for comprehensive regulatory measures to limit microplastic pollution and further research into the long-term neurological health effects.