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20 resultsShowing papers similar to Extracellular Vesicles & Co.: scaring immune cells in the TME since ever
ClearMicroplastic and Extracellular Vesicle Interactions: Recent Studies on Human Health and Environment Risks
This review explores the newly discovered relationship between microplastics and extracellular vesicles, tiny particles that cells use to communicate with each other. Evidence indicates that microplastics can alter how these vesicles are distributed and what molecular signals they carry, potentially disrupting normal cell communication. Understanding this interaction could provide important insights into how microplastic exposure may contribute to inflammation, metabolic changes, and other health effects.
Tumorigenic and tumoricidal properties of exosomes in cancers; a forward look
This review explores how tiny cell-released vesicles called exosomes can either promote or fight cancer by transferring signaling molecules between cells. While not directly about microplastics, the research is relevant because nanoplastics are similar in size to exosomes and may interfere with these important cell communication pathways. Understanding how nanoscale particles affect cell signaling could help explain some of the biological effects of nanoplastic exposure.
New insights into the potential effects of PET microplastics on organisms via extracellular vesicle-mediated communication
Researchers discovered that PET microplastics can be transported within the body through tiny cellular packages called extracellular vesicles, which cells naturally use to communicate with each other. They found that exposure to PET microplastics altered the content and behavior of these vesicles, potentially allowing plastic particles to reach tissues beyond the initial site of exposure. The study reveals a previously unknown biological pathway through which microplastics may spread their effects throughout organisms.
Role of microplastics in the tumor microenvironment (Review)
This review examines how microplastics may help tumors grow by influencing the environment around cancer cells. Microplastics can interact with immune cells, connective tissue cells, blood vessel cells, and the tissue scaffolding around tumors in ways that may promote cancer progression and inflammation. While more research is needed, the findings raise important questions about whether chronic microplastic exposure could affect cancer development in humans.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
This study reviewed how nanoplastic particles disrupt the bone microenvironment through oxidative stress and damage to the extracellular matrix. Reactive oxygen species generated by nanoplastic exposure were found to drive toxicity in bone cells.
Investigation of cell-to-cell transfer of polystyrene microplastics through extracellular vesicle-mediated communication
Scientists discovered that cells can transfer polystyrene microplastic particles to other cells through tiny membrane-enclosed packages called extracellular vesicles. This finding reveals a previously unknown mechanism for how microplastics could spread between cells in the body, potentially explaining how plastic particles move through tissues after initial exposure.
Unraveling the impact of nanoplastics on bone microenvironment: focus on extracellular vesicle-mediated communication and oxidative stress in multiple myeloma.
Researchers reviewed how nanoplastics affect the bone microenvironment, focusing on oxidative stress pathways and extracellular matrix disruption as key mechanisms of toxicity. Reactive oxygen species generated by nanoplastic exposure were identified as drivers of bone cell damage.
Guidelines for the purification and characterization of extracellular vesicles of parasites
This paper provides guidelines for scientists studying extracellular vesicles released by parasites, which play roles in infection and immune evasion. While not about microplastics, the standardized methods described here for isolating and analyzing tiny biological particles are relevant to microplastics research, where similar techniques are needed to study how nanoplastics interact with cells. Better laboratory standards across these fields help improve the quality of research on tiny particle exposure and health effects.
The Impact of Microplastics on Biological Systems: A Focus on Extracellular Vesicles and miRNA Profiles
This review examines how microplastics affect biological systems with a focus on extracellular vesicles, discussing how MP exposure alters vesicle release and composition in ways that may propagate cellular stress signals throughout tissues and contribute to systemic health effects.
Tumour-associated macrophages: versatile players in the tumour microenvironment
This review explores tumour-associated macrophages, immune cells that play complex and sometimes contradictory roles in cancer, both helping tumours grow and fighting them. Researchers describe newly discovered behaviors of these cells, including their ability to transform into other cell types. The study highlights the potential of targeting these macrophages as a strategy in cancer immunotherapy.
Distinct targeting and uptake of platelet and red blood cell‐derived extracellular vesicles into immune cells
This study examined how tiny vesicles (small bubble-like particles) released by platelets and red blood cells interact with immune cells. Platelet-derived vesicles were taken up by certain immune cells much faster than red blood cell vesicles, and neither type affected T-cells. While not directly about microplastics, the research is relevant because it helps scientists understand how small particles in the blood, including nanoplastics, might interact with the immune system.
Intratumoural microbiota: from theory to clinical application
Researchers reviewed how bacteria living inside tumors — called intratumoural microbiota — influence cancer development, immune responses, and treatment outcomes. They highlight that while some tumor-resident microbes drive cancer progression by damaging DNA and disrupting immune signaling, engineered bacteria could be harnessed as novel therapeutic tools to target tumors directly.
Nanoplastics and Immunity: Investigating the Extracellular Matrix’s Influence on Macrophage Interaction with Polystyrene Nanoparticles
Researchers investigated how extracellular matrix components affect macrophage uptake of polystyrene nanoplastics, finding that the surrounding matrix modulates nanoplastic-immune cell interactions — with implications for understanding how nanoplastics evade or engage the innate immune response.
Investigation of Cell-to-cell Transfer of Polystyrene Microplastics Through Extracellular Vesicle-mediated Communication
Researchers investigated cell-to-cell transfer of polystyrene microplastics through extracellular vesicles, finding that cells can package and transfer plastic particles via vesicle-mediated pathways, a previously unrecognized route for intracellular plastic dissemination.
Extracellular vesicles as mediators of metabolomic changes in response to PET microplastics
Researchers fed piglets PET microplastics (a common plastic used in food packaging) and found that the particles changed the chemical signals carried by extracellular vesicles, which are tiny messengers that cells use to communicate with each other. The altered signals disrupted fat processing, energy production, sugar metabolism, and hormone production. This reveals a previously unknown way that microplastics could cause widespread disruption throughout the body.
The quest for nanoparticle-powered vaccines in cancer immunotherapy
This review explores how nanoparticles are being developed as cancer vaccine delivery systems to train the immune system to fight tumors more effectively. While focused on cancer immunotherapy rather than microplastics, the research highlights that understanding how nanoparticles interact with the immune system is crucial -- the same principles apply to understanding how nanoplastics may affect immune responses in the body.
Detection and quantification of microplastics in various types of human tumor tissues
Researchers detected microplastics in 43% of tumor samples across lung, gastric, colorectal, cervical, and pancreatic cancers, with polystyrene, PVC, and polyethylene being the types found. In pancreatic tumors, microplastic presence was associated with fewer immune cells that fight cancer and more immune cells linked to tumor progression, suggesting microplastics may create conditions that help tumors evade the immune system.
Reversing the immunosuppressive microenvironment with reduced redox level by microwave-chemo-immunostimulant Ce–Mn MOF for improved immunotherapy
Researchers developed a nanoparticle-based treatment that combines microwave energy, chemotherapy, and immune activation to reverse the protective environment that tumors create to hide from the immune system. In animal experiments, this combined approach significantly increased immune cell infiltration into tumors and improved the body's ability to fight cancer beyond the treated area.
International Society for Extracellular Vesicles workshop. QuantitatEVs: Multiscale analyses, from bulk to single extracellular vesicle
This workshop report summarizes discussions among scientists about improving methods for measuring and analyzing extracellular vesicles, which are tiny particles released by cells. Researchers explored strategies for standardizing both laboratory techniques and computational approaches, from bulk samples down to individual vesicles. The report identifies key challenges and emerging technologies needed to advance this rapidly growing field of biomedical research.
[Effects and Mechanisms of Polystyrene Microplastics on Extracellular Antibiotic Resistance Genes in Wastewater].
This Chinese-language study reviewed the effects and mechanisms of polystyrene microplastics on extracellular vesicle production and composition, examining how microplastic exposure alters cell-to-cell communication pathways. The research contributes to understanding subcellular responses to microplastic exposure in biological systems.