Papers

61,005 results
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Article Tier 2

Evaluation of genotoxic and mutagenic potential of polystyrene nanoplastics in forked venus clam, Gafrarium divaricatum (Gmelin, 1791)

Researchers evaluated the genotoxic and mutagenic effects of polystyrene nanoplastics on an intertidal clam species over exposure periods of 96 hours and 15 days. They found significant time- and concentration-dependent DNA damage, micronuclei formation, and altered expression of stress and DNA repair genes in gill and intestinal tissues. The study demonstrates that nanoplastics can cause genetic damage in marine bivalves, raising concerns about their ecological impact.

2025 Journal of Hazardous Materials Advances 1 citations
Article Tier 2

Transcriptomic analysis following polystyrene nanoplastic stress in the Pacific white shrimp, Litopenaeus vannamei

Researchers used transcriptomic analysis to study how polystyrene nanoplastics affect gene expression in Pacific white shrimp. They found that nanoplastic exposure activated lysosome pathways and disrupted genes involved in immune response, protein processing, and metabolism. The study provides molecular-level evidence that nanoplastics can interfere with multiple biological systems in commercially important shrimp species.

2023 Fish & Shellfish Immunology 15 citations
Article Tier 2

Transcriptomic responses of Antarctic clam Laternula elliptica to nanoparticles, at single and combined exposures reveal ecologically relevant biomarkers

Researchers exposed Antarctic clams to polystyrene nanoparticles and titanium dioxide nanoparticles, finding that both types altered gene expression in ways affecting immune function, antioxidant defenses, lipid metabolism, and cell structure — with the combined exposure producing a distinct response. Four specific gene transcripts were identified as reliable biomarkers for nanoparticle exposure, offering tools for monitoring pollution in the fragile Antarctic ecosystem.

2024 Ecotoxicology and Environmental Safety 3 citations
Article Tier 2

Sequencing data of Amphiprion ocellaris (clownfish) exposed to polystyrene nanoplastic

Researchers exposed clownfish to polystyrene nanoplastics at environmentally relevant and high concentrations for seven days and performed biochemical and transcriptomic analyses. The study found that even low-concentration exposure triggered significant gene expression changes indicating energy reallocation and stress responses, while high concentrations amplified these effects and activated additional inflammatory and detoxification pathways.

2026 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Sequencing data of Amphiprion ocellaris (clownfish) exposed to polystyrene nanoplastic

Researchers exposed clownfish to polystyrene nanoplastics at environmentally relevant and high concentrations for seven days and performed biochemical and transcriptomic analyses. The study found that even low-concentration exposure triggered significant gene expression changes indicating energy reallocation and stress responses, while high concentrations amplified these effects and activated additional inflammatory and detoxification pathways.

2026 Zenodo (CERN European Organization for Nuclear Research)
Article Tier 2

Ion transport and metabolic regulation induced by nanoplastic toxicity in gill of Litopenaeus vannamei using proteomics

Researchers used proteomics to study how nanoplastics affect the gills of Pacific white shrimp, a widely farmed seafood species. They found that high concentrations of nanoplastics damaged gill tissue, disrupted ion balance, triggered oxidative stress, and altered energy metabolism. The study reveals the molecular mechanisms through which nanoplastic pollution may threaten the health of commercially important aquaculture species.

2025 Environmental Science Nano 2 citations
Article Tier 2

Environmental and Sublethal Concentrations of Polystyrene Nanoplastics Induced Antioxidant System, Transcriptomic Responses, and Disturbed Gut Microbiota in Oyster Magallana Hongkongensis

Researchers exposed Hong Kong oysters to polystyrene nanoplastics at both environmentally realistic and higher concentrations. Even at the lower, real-world concentrations, the nanoplastics significantly altered the oysters' gut bacteria and gene expression patterns, while higher doses also triggered immune and antioxidant stress responses, raising concerns about food safety and ecosystem health.

2024 Journal of Agricultural and Food Chemistry 9 citations
Article Tier 2

Exposure to nanoplastics and nanomaterials either single and combined affects the gill-associated microbiome of the Antarctic soft-shelled clam Laternula elliptica

Researchers exposed the Antarctic soft-shell clam Laternula elliptica to polystyrene nanoparticles and nano-titanium dioxide — alone and combined — and found that both nanomaterials shift the gill-associated microbiome toward potentially harmful bacterial taxa, with combined exposure amplifying changes in metabolic functions related to nutrient and DNA processing.

2024 Marine Environmental Research 12 citations
Article Tier 2

Distinguish the toxic differentiations between acute exposure of micro- and nano-plastics on bivalves: An integrated study based on transcriptomic sequencing

Researchers found that nanoplastics are more toxic than microplastics in mussels, causing severe inflammatory responses and greater oxidative stress, with transcriptomic analysis revealing contrasting gene expression patterns between the two particle sizes.

2022 Aquatic Toxicology 35 citations
Article Tier 2

Effects of nanoplastics on clam Ruditapes philippinarum at environmentally realistic concentrations: Toxicokinetics, toxicity, and gut microbiota

Researchers exposed clams to nanoplastics at concentrations found in real marine environments and tracked how the particles accumulated in their tissues over 14 days. The nanoplastics caused physical damage and significantly altered the clams' gut bacteria. This is concerning because clams are widely consumed seafood, meaning nanoplastic contamination could affect both marine ecosystems and human food sources.

2023 Journal of Hazardous Materials 33 citations
Article Tier 2

Gradual effects of gradient concentrations of polystyrene nanoplastics on metabolic processes of the razor clams

Researchers exposed razor clams to a gradient of polystyrene nanoplastic concentrations and used metabolomics to track effects, finding that even low concentrations disrupted energy metabolism and amino acid pathways, with effects becoming more severe as concentration increased.

2021 Environmental Pollution 47 citations
Article Tier 2

Physiological and transcriptomic analyses reveal critical immune responses to hypoxia and sulfide in the haemolymph of clam Tegillarca granosa

This paper is not relevant to microplastics research — it examines how hypoxia and sulfide exposure affect immune responses in blood clams (Tegillarca granosa) at a physiological and transcriptomic level.

2023 Frontiers in Marine Science 10 citations
Article Tier 2

Effects of exposure to nanoplastics on the gill of mussels Mytilus galloprovincialis: An integrated perspective from multiple biomarkers

Researchers exposed Mediterranean mussels to polystyrene nanoplastics for seven days and measured multiple gill biomarkers, finding that nanoplastics triggered oxidative stress, inhibited acetylcholinesterase, disrupted sodium-potassium ion transport, and impaired energy and lipid metabolism, pointing to broad physiological interference in marine invertebrates.

2023 Marine Environmental Research 14 citations
Article Tier 2

Polystyrene nanoplastic induces oxidative stress, immune defense, and glycometabolism change in Daphnia pulex: Application of transcriptome profiling in risk assessment of nanoplastics

Researchers used transcriptome sequencing to examine how polystyrene nanoplastics affect gene expression in the water flea Daphnia pulex. After 96 hours of exposure, they identified 208 genes with altered expression levels, linked to oxidative stress, immune defense, and sugar metabolism pathways. The study provides molecular-level evidence that nanoplastic pollution can trigger multiple stress responses in freshwater organisms.

2020 Journal of Hazardous Materials 167 citations
Article Tier 2

Toxicity of environmental and polystyrene plastic particles on the bivalve Corbicula fluminea: focus on the molecular responses

Researchers exposed freshwater bivalves to environmental microplastics and nanoplastics collected from a river, as well as to laboratory polystyrene nanoparticles, and measured molecular-level responses. Gene expression analysis revealed that plastic particle exposure activated stress response and immune defense pathways in gill and visceral tissues. The study indicates that even environmentally relevant concentrations of plastic particles can trigger measurable biological stress in filter-feeding organisms.

2024 Ecotoxicology 2 citations
Article Tier 2

From Antioxidant Defenses to Transcriptomic Signatures: Concentration-Dependent Responses to Polystyrene Nanoplastics in Reef Fish

Researchers exposed clownfish to polystyrene nanoplastics at low and high concentrations for seven days and assessed toxic effects using biochemical and gene expression analyses. While standard antioxidant biomarkers showed limited changes, transcriptomic analysis revealed significant alterations in stress response and metabolic pathways at higher concentrations. The study suggests that conventional biomarkers may underestimate nanoplastic toxicity, and that molecular-level analysis is needed to capture the full scope of effects on reef fish.

2026 Microplastics
Article Tier 2

Effects of medium-term exposure to a high concentration of polystyrene nanoplastics in Chilean mussels (Mytilus chilensis)

Researchers exposed Chilean mussels to high concentrations of polystyrene nanoplastics for 28 days and observed an initial antioxidant and immune response in gills that declined over time, with histological changes including hemocytic infiltration and epithelial damage in gills, the primary site of nanoplastic accumulation.

2026 Marine Pollution Bulletin
Article Tier 2

Transcriptomic analysis reveals nanoplastics-induced apoptosis, autophagy and immune response in Litopenaeus vannamei

Shrimp exposed to polystyrene nanoplastics for 28 days showed dose-dependent damage to their immune systems, including increased cell death, tissue destruction in the liver-like organ, and disrupted antioxidant defenses. At high concentrations, the nanoplastics overwhelmed the shrimp's ability to fight off threats. Since shrimp are an important food source, these findings raise concerns about the quality and safety of seafood from nanoplastic-contaminated waters.

2024 The Science of The Total Environment 10 citations
Article Tier 2

Transcriptional response in the whiteleg shrimp (Penaeus vannamei) to short-term microplastic exposure

Researchers exposed whiteleg shrimp (Penaeus vannamei) to microplastics for 96 hours and used transcriptomics to profile gene expression changes, finding significant upregulation of stress response, immune, and detoxification pathways, indicating that even short-term microplastic exposure triggers a broad molecular stress response.

2021 Aquaculture Reports 26 citations
Article Tier 2

Effects of subchronic exposure to PFOA and nanoplastics on the gills of Eriocheir sinensis: Perspectives from the transcriptome, microbiome and physiology

Researchers exposed Chinese mitten crabs (Eriocheir sinensis) to PFOA and nanoplastics for 28 days and used transcriptomic, metabolomic, and microbiomic analyses to show that both pollutants damage gill tissue through oxidative stress, inflammation, apoptosis, and disruption of lipid metabolism, with combined exposure also reshaping the gill microbial community.

2026 Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology
Article Tier 2

Effects of microplastics on gene expression to nonspecific immune system in pacific white shrimp (Litopenaeus vannamei).

This study found that high-density polyethylene microplastic particles in shrimp feed suppressed immune defense genes in Pacific white shrimp and caused intestinal and gill tissue damage at concentrations well below lethal levels. The findings suggest that microplastic exposure could compromise immune function and health in farmed crustaceans.

2022 1 citations
Article Tier 2

Toxicological effects of polystyrene nanoplastics on marine organisms

Researchers exposed Pacific white shrimp to polystyrene nanoplastics at various concentrations and measured immune, antioxidant, and tissue responses after seven days. They found that nanoplastic exposure disrupted immune function, increased oxidative stress, and caused tissue damage, particularly in the hepatopancreas and gills. The study adds to growing evidence that nanoplastics can harm the health of commercially important marine species.

2023 Environmental Technology & Innovation 32 citations
Article Tier 2

Effects of polystyrene nanoplastics on the amino acid composition of Asian Clam (Corbicula fluminea)

Researchers exposed Asian clams (Corbicula fluminea) to polystyrene nanoplastics and measured changes in their amino acid composition, finding significant alterations in essential and non-essential amino acid profiles compared to unexposed controls. The results indicate that nanoplastic exposure disrupts protein metabolism in bivalves, which could have cascading effects on clam nutrition and health.

2024 LWT 4 citations
Article Tier 2

Functionalized polystyrene nanoplastic-induced energy homeostasis imbalance and the immunomodulation dysfunction of marine clams (Meretrix meretrix) at environmentally relevant concentrations

Functionalized polystyrene nanoplastics inhibited growth of marine clams (Meretrix meretrix) at environmentally relevant concentrations by disrupting energy homeostasis and immune function. The study demonstrated that surface functionalization of nanoplastics influences their toxicity to filter-feeding bivalves.

2021 Environmental Science Nano 54 citations