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61,005 resultsShowing papers similar to Drosophila melanogaster as a tractable eco-environmental model to unravel the toxicity of micro- and nanoplastics
ClearThe effects of microplastics and nanoplastics upon history, policies, and Drosophila melanogaster
This study examined the effects of microplastics and nanoplastics on the fruit fly Drosophila melanogaster, finding that dietary exposure to these pervasive environmental contaminants causes measurable biological harm and making the case for stronger regulatory policies.
Nanoplastics and Microplastics and Their Impact on Male Reproduction—Uncovering the Hidden Hazards Using the Drosophila Model
Using Drosophila as a model organism, researchers investigated the impact of micro- and nanoplastics on male reproductive health, finding that exposure impaired reproductive output and sperm quality. The study validates Drosophila as an ethical, cost-effective model for assessing reproductive toxicity of microplastics.
No evidence for behavioral or physiological effects of nanoplastics ingestion in the fruit fly Drosophila melanogaster
Researchers exposed Drosophila melanogaster to low and high concentrations of nanoplastics (1 µg/g and 1 mg/g) across several generations and measured emergence rate, mitochondrial activity, metabolism, body mass, and locomotion. No significant behavioral or physiological effects were detected, suggesting Drosophila may be less sensitive to nanoplastics than aquatic species.
Polystyrene microplastics alter physiological parameters in the Drosophila model
Researchers investigated the effects of polystyrene micro- and nanoplastics on fruit flies (Drosophila melanogaster) and found dose- and size-dependent toxicity at both larval and adult stages. Exposure caused significant behavioral impairments, elevated markers of cellular stress, and activated key stress response genes, indicating that polystyrene microplastics induce oxidative stress and cellular damage.
Size-dependent and sex-specific negative effects of micro- and nano-sized polystyrene particles in the terrestrial invertebrate model Drosophila melanogaster
Fruit flies exposed to low doses of polystyrene micro and nanoparticles for 28 days showed tissue damage in their gut, ovaries, and testes, with smaller particles causing more harm. The plastics triggered oxidative stress and cell death in gut tissue, though reproduction was not significantly affected at these doses. This study, using a well-established model organism, suggests that even low-level, long-term exposure to tiny plastic particles can damage internal organs, with potential implications for other species including humans.
Investigation of the effects of nanoplastic polyethylene terephthalate on environmental toxicology using model Drosophila melanogaster
Researchers synthesized polyethylene terephthalate nanoplastics and fed them to fruit flies to assess their toxic effects. The nanoplastics caused increased oxidative stress, reduced survival rates, and impaired reproductive capacity in the exposed flies. The study demonstrates that PET nanoplastics, one of the most common plastic types in food and beverage packaging, can have measurable toxic effects on living organisms.
Metabolic effects of dietary exposure to polystyrene microplastic and nanoplastic in fruit flies
Researchers used fruit flies as a model organism to study the metabolic effects of ingesting polystyrene microplastic and nanoplastic particles at environmentally relevant doses. They found that both particle sizes disrupted metabolic processes, with nanoplastics causing more pronounced changes in energy storage and lipid metabolism. The study suggests that dietary exposure to plastic particles, even at levels found in the environment, can meaningfully alter metabolic physiology.
Drosophila melanogaster as sentinel organism for hazard identification of environmental contaminants
This review highlights how the common fruit fly (Drosophila melanogaster) is being used as a model organism to study the toxic effects of environmental pollutants, including microplastics, nanomaterials, and heavy metals. Researchers found that fruit flies offer genetic tools and measurable endpoints like survival, reproduction, and behavior that make them valuable for identifying hazards and discovering biomarkers. The study underscores the fruit fly's growing role in advancing our understanding of how environmental contaminants affect living organisms.
Polyethylene microplastics affect behavioural, oxidative stress, and molecular responses in the Drosophila model
Fruit flies exposed to polyethylene microplastics showed reduced climbing and crawling ability, increased oxidative stress, and activation of genes involved in cell death and stress responses. The microplastics overwhelmed the flies' antioxidant defenses and triggered the same cellular damage pathways associated with disease in mammals. Since fruit flies share many biological pathways with humans, these findings suggest that microplastic exposure could cause similar oxidative damage and stress responses in human cells.
Polyethylene microplastics induce behavioural and developmental deficits in the Drosophila model
Researchers generated polyethylene microplastics sized 2-10 micrometers and tested their effects on fruit flies (Drosophila). They found that exposure caused severe declines in fly longevity, reduced locomotor function in both larvae and adults, decreased eclosion rates, and increased antioxidant enzyme activity along with stress-response gene activation. The findings provide evidence that polyethylene microplastics can impair growth, development, and survival in a well-established animal model.
Effects of PET microplastics on the physiology of Drosophila
Researchers used Drosophila fruit flies as a model to study the physiological effects of PET microplastics, finding that ingestion affected reproduction, lifespan, and gut function. The study suggests that even common plastic types found in food packaging can have measurable biological effects when consumed by living organisms.
Plastic Fly: What Drosophila melanogaster Can Tell Us about the Biological Effects and the Carcinogenic Potential of Nanopolystyrene
Researchers used fruit flies as a model organism to investigate whether polystyrene nanoplastics can cause genetic damage and promote tumor growth. They found that nanoplastic exposure led to DNA damage and increased tumor formation in the flies, with effects worsening at higher concentrations. The study suggests that nanoplastics commonly found in food packaging may carry cancer-promoting potential that warrants further investigation.
The heart of plastic: utilizing the Drosophila model to investigate the effects of micro/nanoplastics on heart function
Researchers used fruit flies as a model to study how micro- and nanoplastics affect heart function, an area with very limited research despite the known presence of plastics in human cardiovascular tissue. They reviewed existing evidence showing that plastic particles can alter heart rate, trigger stress responses, and accumulate in cardiac tissue. The study highlights the fruit fly as a fast, affordable model for investigating the potential cardiovascular risks of plastic pollution.
A mini review on exposure of microplastic to Drosophila melanogaster causing sex-specific, transgenerational, locomotory, physiological and developmental effect
This mini-review synthesized studies on how polystyrene and PET microplastics affect Drosophila melanogaster across multiple biological levels including sex-specific responses, physiology, behavior, development, and transgenerational effects. Male Drosophila showed greater sensitivity to microplastics with higher mortality, and effects were both concentration- and size-dependent.
Polypropylene microplastics affect the physiology in Drosophila model
Researchers found that polypropylene microplastics negatively affected the physiology of Drosophila fruit flies, complementing earlier work on polyethylene terephthalate microplastics and demonstrating that different polymer types can impair organism health.
Exposure of polystyrene microplastics induces oxidative stress and physiological defects in Drosophila melanogaster
Researchers used fruit flies as a model organism to study the effects of polystyrene microplastics and found that dietary exposure caused significant oxidative stress at both tested concentrations. The microplastics impaired climbing ability in adult flies and disrupted normal development patterns during the pupal stage. The study suggests that microplastic ingestion can trigger oxidative damage and physiological defects even in relatively simple organisms.
Toxicological Profile of Polyethylene Terephthalate (PET) Microplastic in Ingested Drosophila melanogaster (Oregon R+) and Its Adverse Effect on Behavior and Development
Researchers fed PET microplastics to fruit flies and found that the particles accumulated in their bodies and caused dose-dependent declines in movement, climbing ability, and survival rates. Higher microplastic concentrations also slowed the flies' development from larvae to adults. While fruit flies are a simple model organism, these behavioral and developmental effects suggest that chronic microplastic ingestion could impair neurological and physiological functions in animals exposed through their diet.
Intake of polyamide microplastics affects the behavior and metabolism of Drosophila
Researchers found that exposure to polyamide microplastics altered feeding behaviour, reduced triglyceride and protein levels, and disrupted metabolism in Drosophila, with effects differing between sexes and increasing in severity at higher microplastic concentrations.
Polystyrene micro- and nanoplastics affect locomotion and daily activity ofDrosophila melanogaster
Uptake and effects of polystyrene micro- and nanospheres on Drosophila melanogaster were studied, finding that both sizes of plastic particles affected locomotion and daily activity patterns. The results suggest that microplastic and nanoplastic ingestion can disrupt behavioral functions in the fruit fly model.
Exposure to polystyrene microplastic beads causes sex-specific toxic effects in the model insect Drosophila melanogaster
Researchers fed fruit flies (Drosophila) polystyrene microplastics and found toxic effects that differed between males and females. Exposed flies showed changes in feeding behavior, digestion, and excretion, with females experiencing greater reproductive impacts. This study is significant because it demonstrates that microplastic toxicity can be sex-specific, suggesting that health effects in humans might also differ between men and women.
Adverse biological effects of ingested polystyrene microplastics using Drosophila melanogaster as a model in vivo organism
Researchers used fruit flies as an in vivo model to study the biological effects of ingesting polystyrene microplastics at three different sizes. Exposure caused significant morphological defects, impaired climbing behavior, and genotoxic effects as shown by a somatic mutation test. The findings suggest that polystyrene microplastics may induce genetic damage primarily through somatic recombination, raising concerns about their potential biological impact on living organisms.
Changes in the wing shape and size in fruit flies exposed to micro and nanoplastics
Researchers exposed fruit flies to polystyrene nano- and microplastics during development and then measured changes in wing shape and size using geometric morphometrics. They found that exposed flies had altered wing dimensions compared to controls, with effects varying between males and females. The study demonstrates that plastic particle exposure during early development can produce measurable physical changes in organisms.
Transgenerational effects on development following microplastic exposure in Drosophila melanogaster
Researchers fed Drosophila melanogaster flies plastic-supplemented food and found that while treated flies showed changes in fertility and sex ratio, their unexposed offspring had shorter larval development and reduced adult size, demonstrating transgenerational developmental effects from parental microplastic exposure.
Sex-specific toxicity of PMMA Microplastics: Behavioral and metabolic dysregulation in adult Drosophila melanogaster
Drosophila melanogaster flies exposed to PMMA microplastics for 20 days showed sex-specific responses — males had enhanced motor activity while females showed metabolic disruption and shortened lifespan — highlighting the importance of considering sex differences in microplastic toxicity studies.