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Polyethylene microplastics induce behavioural and developmental deficits in the Drosophila model
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Researchers generated polyethylene microplastics sized 2-10 micrometers and tested their effects on fruit flies (Drosophila). They found that exposure caused severe declines in fly longevity, reduced locomotor function in both larvae and adults, decreased eclosion rates, and increased antioxidant enzyme activity along with stress-response gene activation. The findings provide evidence that polyethylene microplastics can impair growth, development, and survival in a well-established animal model.
Abstract Introduction Polyethylene (PE) is a common plastic used in a variety of applications such as bottles, carry bags, and packaging materials. The extensive use and improper disposal of PE MPs have severe environmental impacts. PE MPs infiltrate ecosystems via wastewater discharge and landfill runoff, getting consumed by organisms and causing harmful bioaccumulation. These microplastics also absorb toxins and transport them up the food chain, posing health risks to humans. Objectives and methods We generated PE MPs with sizes between 2 and 10 μm and assessed their toxicity on the Drosophila model. The study included an evaluation of the survival patterns of adult flies and behavioural and biochemical parameters in larvae and adults. Results Our in vivo toxicological assessment revealed a severe decline in the longevity of flies and locomotory function in the larvae and adults. In addition, we also noticed a decrease in the fly eclosion rate and a substantial increase in the antioxidant enzyme activity. This result was further supported by the alterations observed in the transcriptional activation of stress response genes like Hsp70Bc , rpr , cat , p53 and sod . Conclusion The findings from the study reveal perspectives on the harmful impacts of PE MPs on flies’ growth and development, as well as the rising threat to our environment posed by these microplastics. Graphical abstract
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