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61,005 resultsShowing papers similar to Exposure to Nanoplastics Cause Caudal Vein Plexus Damage and Hematopoietic Dysfunction by Oxidative Stress Response in Zebrafish (Danio rerio)
ClearNanoplastic Exposure Mediates Neurodevelopmental Toxicity by Activating the Oxidative Stress Response in Zebrafish (Danio rerio)
Exposure to 20-nanometer plastic particles caused developmental problems in zebrafish embryos, including shorter body length, heart defects, and lower survival rates. The nanoplastics specifically damaged the development of motor neurons and triggered oxidative stress, a harmful chemical imbalance in cells. These results suggest that very small plastic particles could interfere with early brain and nerve development.
Polystyrene Nanoplastic Exposure Induces Developmental Toxicity by Activating the Oxidative Stress Response and Base Excision Repair Pathway in Zebrafish (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and found significant developmental abnormalities including reduced hatching rates and increased malformations. The nanoplastics activated oxidative stress responses and DNA repair pathways, indicating cellular damage during critical early development stages. The study provides mechanistic evidence for how nanoplastic exposure can disrupt normal embryonic development in aquatic organisms.
Polystyrene nanoplastics induce developmental impairments and vasotoxicity in zebrafish (Danio rerio)
Zebrafish exposed to polystyrene nanoplastics at environmentally realistic concentrations showed developmental problems including heart defects, brain abnormalities, blood vessel damage, and reduced swimming ability. The nanoplastics accumulated on the fish's body and triggered cell damage and oxidative stress even at very low doses. Since zebrafish are commonly used to model human developmental processes, these findings raise concerns about what nanoplastic exposure could mean for early human development.
Polystyrene nanoplastics cause developmental abnormalities, oxidative damage and immune toxicity in early zebrafish development
Zebrafish embryos exposed to polystyrene nanoplastics showed dose-dependent developmental problems including delayed hatching, reduced survival, smaller body size, and the nanoplastics accumulated in critical organs like the eyes, heart, liver, and brain. The particles triggered oxidative stress that damaged cells and activated inflammatory immune responses, demonstrating how nanoplastic contamination in water can cause widespread harm to developing organisms.
Cardiovascular toxicity assessment of polyethylene nanoplastics on developing zebrafish embryos
Researchers assessed the cardiovascular effects of polyethylene nanoplastics on developing zebrafish embryos and found that exposure above 50 micrograms per milliliter caused pericardial edema, reduced cardiac output, and impaired blood vessel formation. The nanoplastics also triggered oxidative stress and inflammation, which contributed to blood clot formation in the embryos. The study suggests that nanoplastic exposure could pose risks to cardiovascular development in living organisms.
Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment
This review examines how nano- and micro-sized plastic particles cause toxic effects in zebrafish, focusing on the link between oxidative stress and neurodevelopmental damage. Researchers found that plastic particle exposure disrupts the balance of reactive oxygen species in cells, which can impair brain development and nervous system function. The study suggests these oxidative stress responses may serve as early warning signals of plastic particle toxicity in aquatic organisms.
Nanoplastics exposure induces vascular malformation by interfering with the VEGFA/VEGFR pathway in zebrafish (Danio rerio)
Researchers found that nanoplastics exposure causes vascular malformation in zebrafish embryos by disrupting the VEGFA/VEGFR signaling pathway, providing new insight into how plastic nanoparticles can impair cardiovascular development.
Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption
Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.
Developmental cardiovascular disruption triggered by polystyrene nanoplastics in zebrafish mediated through oxidative stress
Researchers exposed zebrafish embryos to polystyrene nanoplastics and observed disrupted heart development, including abnormal heart rate, swelling around the heart, and impaired blood vessel formation. The damage was linked to oxidative stress, and treatment with the antioxidant glutathione significantly reduced the harmful effects. The findings suggest that nanoplastic pollution in waterways may pose risks to cardiovascular development and that antioxidant-based strategies could help counteract the damage.
Embryotoxicity of polystyrene microplastics in zebrafish Danio rerio
Researchers exposed zebrafish embryos to polystyrene microplastics during early development and observed serious physical deformities, particularly in the spine, tail, and eyes, despite no increase in mortality. The exposed larvae also showed elevated expression of genes involved in oxidative stress defense and cellular detoxification. The findings suggest that microplastics can disrupt critical developmental stages in freshwater fish even when they do not directly cause death.
Polystyrene nanoplastics (20 nm) are able to bioaccumulate and cause oxidative DNA damages in the brain tissue of zebrafish embryo (Danio rerio)
Researchers microinjected 20-nanometer polystyrene nanoplastics into zebrafish embryos to simulate dietary or maternal exposure and tracked their fate over 120 hours. The study found that nanoplastics reached and bioaccumulated in the brain, causing oxidative DNA damage in the regions where they accumulated. The research team used transmission electron microscopy to image nanoplastics in a vertebrate brain for the first time, also observing increased mortality, developmental abnormalities, and elevated reactive oxygen species.
Microplastics induced developmental toxicity with microcirculation dysfunction in zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene microplastics (1 micrometer) and nanoplastics (0.4 micrometer) to assess developmental toxicity. They found that nanoplastics caused significantly higher mortality and more severe microcirculation dysfunction than microplastics, despite being less visible in solution. The study indicates that smaller plastic particles may pose greater developmental risks to aquatic organisms during early life stages.
Exploring developmental toxicity of microplastics and nanoplastics (MNPS): Insights from investigations using zebrafish embryos
This review summarizes research on how micro- and nanoplastics harm embryo development using zebrafish as a model organism that shares genetic similarities with humans. Studies show these tiny plastic particles cause damage to the brain, heart, gut, and immune system of developing embryos, largely through oxidative stress and cell death pathways.
Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure
Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.
Assessing the impact of dietary polystyrene nanoplastics on growth performance, immunological parameters, and antioxidant defense in zebrafish (Danio rerio)
Researchers fed zebrafish diets containing different concentrations of polystyrene nanoplastics for 30 days and observed reduced growth and increased stress markers at higher doses. The study found that nanoplastic exposure triggered oxidative stress, elevated cortisol levels, and altered immune-related gene expression, suggesting potential health impacts on fish from dietary nanoplastic intake.
Polystyrene nanoplastics mediate skeletal toxicity through oxidative stress and the BMP pathway in zebrafish (Danio rerio)
Exposing zebrafish embryos to polystyrene nanoplastics caused skeletal deformities, reduced body length, and disrupted bone development pathways. The nanoplastics triggered oxidative stress and cell death in developing bone tissue, with longer exposure periods causing worse outcomes. While this study was conducted in fish, the bone development pathways affected are similar to those in humans, raising questions about whether nanoplastic exposure could affect skeletal development.
Genotoxic and Oxidative Damage of Environmental Pollutant Microplastics on Zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene and polyethylene microplastics at different concentrations for up to 21 days to measure oxidative stress and DNA damage. The study found that both types of microplastics disrupted the antioxidant system and caused measurable DNA damage, with effects depending on dosage and exposure time. These results suggest that microplastics in waterways could pose genetic and cellular risks to aquatic life.
Toxic effect of chronic exposure to polyethylene nano/microplastics on oxidative stress, neurotoxicity and gut microbiota of adult zebrafish (Danio rerio)
Researchers exposed adult zebrafish to polyethylene microplastics and nanoplastics for 21 days and found both caused oxidative damage to organs, disrupted brain function, and altered gut bacteria. Surprisingly, the toxic effects of microplastics and nanoplastics were similar in terms of brain and gut impacts, though organ-level oxidative damage varied by tissue type. These findings are concerning because they show that the plastic particles commonly found in food and water can simultaneously harm the brain, gut, and vital organs.
Study of the effects of nanoplastics ingestion in a freshwater fish ( Danio rerio )
Researchers exposed zebrafish to polystyrene nanoplastics and found evidence of intestinal damage, oxidative stress, and behavioral changes. The study adds to growing evidence that nanoplastics in freshwater environments can harm fish health, with potential implications for the health of ecosystems and fish-eating humans.
A mechanistic understanding of the effects of polyethylene terephthalate nanoplastics in the zebrafish (Danio rerio) embryo
Researchers exposed zebrafish embryos to nanoplastics made from PET, the plastic commonly used in water bottles and food packaging. The nanoplastics accumulated in the liver, intestine, and kidneys, causing oxidative stress, damaging cell energy systems, and disrupting metabolism. This is the first comprehensive study of PET nanoplastic toxicity mechanisms, and it is particularly relevant because PET is one of the most common plastics that humans encounter daily.
Exposure to microplastics decreases swimming competence in larval zebrafish (Danio rerio)
Researchers exposed zebrafish embryos and larvae to polystyrene microplastics and found that the particles adhered to egg surfaces before being ingested into the stomach and intestines after hatching. At higher concentrations, exposed larvae showed significantly reduced swimming distance and speed, along with upregulated genes related to inflammation and oxidative stress. The study suggests that microplastic exposure can impair swimming ability in larval fish, which could have broader ecological consequences for population fitness.
Polystyrene nanoplastics mediated the toxicity of silver nanoparticles in zebrafish embryos
Researchers studied how polystyrene nanoplastics interact with silver nanoparticles and affect zebrafish embryo development. They found that nanoplastics can act as carriers for silver nanoparticles in water, and the combination altered patterns of oxidative stress, immune response, and metabolic function compared to either pollutant alone. The study highlights how nanoplastics may change the way other environmental contaminants affect aquatic organisms.
Molecular effects of polystyrene nanoplastics toxicity in zebrafish embryos (Danio rerio)
Researchers exposed zebrafish embryos to polystyrene nanoplastics at various concentrations and measured gene expression changes related to stress, inflammation, and DNA repair. They found dose-dependent activation of oxidative stress and apoptotic pathways at the highest concentration, along with inhibition of the neurotransmitter-related gene acetylcholinesterase and DNA repair genes. The study suggests that nanoplastic exposure at the molecular level may compromise cellular defense mechanisms and neurological function in developing fish.
Polystyrene nanoplastics aggravated ecotoxicological effects of polychlorinated biphenyls in on zebrafish (Danio rerio) embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics combined with PCBs (polychlorinated biphenyls, banned industrial chemicals that persist in the environment) and found that nanoplastics significantly worsened PCB toxicity — amplifying damage to bone and heart development and suppressing the genes that normally help detoxify harmful chemicals. The nanoplastics also accumulated in the liver, intestine, and gills of zebrafish rather than being excreted, raising serious concerns about the ecological risks of rising nanoplastic levels in aquatic environments.