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61,005 resultsShowing papers similar to Effects of combined exposure to 17α-methyltestosterone and polystyrene microplastics on lipid metabolism and the nervous system in Danio rerio
ClearPolystyrene microplastics and 17α-Methyltestosterone induce sphingolipid metabolic disruption, leading to liver and brain damage via the liver-brain axis in zebrafish (Danio rerio)
Zebrafish exposed to polystyrene microplastics combined with a synthetic hormone showed severe liver and brain damage through disruption of fat metabolism pathways. The combination of these two common water pollutants was more harmful than either alone, affecting both immunity and metabolism through the liver-brain connection. This research highlights how microplastics can interact with other pollutants in waterways to create amplified health risks for aquatic life and potentially for humans who consume contaminated fish.
Co-exposure to polystyrene microplastics and perfluorooctanoic acid can exacerbate lipid metabolism disorders and liver damage in adult zebrafish
Researchers exposed zebrafish to polystyrene microplastics and the persistent pollutant PFOA separately and together for 28 days, finding that combined exposure caused greater intestinal barrier breakdown, liver damage, lipid metabolism disruption, and gut microbiome dysbiosis than either contaminant alone — raising concerns about nonalcoholic fatty liver disease risk from co-occurring plastic and chemical pollution.
Effects of combined exposure to polystyrene microplastics and 17α-Methyltestosterone on the reproductive system of zebrafish
Researchers exposed zebrafish to polystyrene microplastics combined with a synthetic hormone (17-alpha-methyltestosterone) and found that the combination caused more severe reproductive damage than either substance alone. The co-exposure reduced mature egg and sperm production, disrupted hormone-related gene expression, and lowered reproductive hormone levels. This suggests that microplastics can make the effects of hormone-disrupting chemicals in the environment worse, which is concerning for both wildlife and human reproductive health.
Adverse effects of polystyrene nanoplastic and its binary mixtures with nonylphenol on zebrafish nervous system: From oxidative stress to impaired neurotransmitter system
Researchers investigated the individual and combined effects of polystyrene nanoplastics and the industrial chemical nonylphenol on the zebrafish nervous system over 45 days. Both substances induced oxidative stress and disrupted neurotransmitter systems, with combined exposure generally producing more severe effects on glutamate metabolism and brain tissue damage. The study suggests that the interaction between nanoplastics and co-occurring environmental pollutants can amplify neurotoxic effects in fish.
Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish
When zebrafish were exposed to both polystyrene microplastics and the pesticide cypermethrin together, the combination caused significantly more liver damage than either pollutant alone. The mixture disrupted fat metabolism in the liver and altered gut bacteria in ways not seen with individual exposures. This matters because microplastics and pesticides frequently co-exist in waterways, and their combined effects on fish health could affect the safety of fish as food.
Individual and combined effects of microplastics and diphenyl phthalate as plastic additives on male goldfish: A biochemical and physiological investigation
Male goldfish exposed to both microplastics and the plasticizer chemical DPP (diphenyl phthalate) together showed significant liver damage, disrupted fat and sugar metabolism, and hormonal imbalances including decreased testosterone and increased estrogen. The combined exposure was more harmful than either pollutant alone, demonstrating how microplastics and their chemical additives can work together to disrupt the endocrine system.
Combined hepatotoxicity of imidacloprid and microplastics in adult zebrafish: Endpoints at gene transcription
Researchers investigated the combined liver toxicity of the pesticide imidacloprid and polystyrene microplastics in adult zebrafish over 21 days. The combination caused greater changes in gene expression related to fat and sugar metabolism and inflammatory responses than either contaminant alone. The study suggests that even low concentrations of microplastics and pesticides together may produce more severe hepatotoxic effects than individual exposures.
Synergistic effects of polystyrene microplastics and 17α-methyltestosterone on immune and oxidative stress responses in the gill and liver of Gobiocypris rarus
Researchers investigated the combined effects of polystyrene microplastics and the synthetic hormone 17-alpha-methyltestosterone on the gills and liver of rare minnows. The study found that co-exposure caused the most severe tissue damage, with significant upregulation of immune and oxidative stress genes and disrupted antioxidant enzyme activities, suggesting synergistic toxicity between these two pollutants.
Combined effects of polystyrene microplastics and cadmium on oxidative stress, apoptosis, and GH/IGF axis in zebrafish early life stages
Researchers exposed zebrafish embryos to polystyrene microplastics and cadmium, both alone and together, and found that the combination caused significantly worse effects than either pollutant individually. Co-exposure amplified oxidative stress, increased cell death in the spine and esophagus, and disrupted growth hormone pathways more severely than single exposures. The findings suggest that microplastics and heavy metals in waterways may interact to create heightened risks for developing fish.
Combined effects of co-exposure to microcystin-LR and polystyrene microplastics on growth, brain pathology and thyroid hormone homeostasis in adult zebrafish
Researchers exposed zebrafish to microcystin-LR (a toxin from algal blooms) combined with polystyrene microplastics and found that the combination caused significantly worse brain damage and thyroid hormone disruption than either pollutant alone. The microplastics appeared to overwhelm the fish's ability to compensate for the algal toxin, leading to hormone imbalances that could affect growth and development. This is concerning because algal blooms and microplastics frequently occur together in polluted waterways, and their combined effects on the hormone system may be worse than expected.
Integrated analysis of zebrafish gut microbiota and liver transcriptome responses to polystyrene microplastics and cadmium
Researchers exposed zebrafish to polystyrene microplastics and cadmium, both individually and combined, and found that combined exposure caused more severe disruption to gut bacteria and liver gene expression than either pollutant alone. The study revealed that microplastics decreased beneficial gut bacteria while increasing pathogenic species, and the combined treatment suppressed liver xenobiotic metabolism and antioxidant pathways.
Toxicological effects of microplastics and phenanthrene to zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene microplastics, the pollutant phenanthrene, and a combination of both to assess their toxicity over 24 days. They found that co-exposure amplified oxidative stress, suppressed immune gene expression, and significantly disrupted the gut microbiome compared to either contaminant alone. The study suggests that microplastics can worsen the toxic effects of organic pollutants in aquatic organisms by altering how chemicals accumulate and interact in the body.
The Role of Synthetic Polymers in the Aquatic Environment and Its Implications in Danio Rerio as a Model Organism
Exposing zebrafish to polystyrene microplastics combined with silver nanoparticles caused significantly more oxidative damage, tissue injury in gills and intestines, and higher mortality than either contaminant alone. The study demonstrates that microplastics can act as carriers that enhance the toxicity of co-pollutants like silver nanoparticles, a combination effect that is highly relevant to understanding real-world aquatic contamination where multiple pollutants co-occur.
The impact of co-exposure to polystyrene microplastics and norethindrone on gill histology, antioxidant capacity, reproductive system, and gut microbiota in zebrafish (Danio rerio)
Zebrafish exposed to polystyrene microplastics and norethindrone (a synthetic hormone found in birth control pills and waterways) for 30 days showed gill damage, reduced antioxidant defenses, disrupted sex hormones, and altered gut bacteria. The combination of the two pollutants was often more harmful than either alone, particularly for reproductive function. This is relevant to human health because both microplastics and pharmaceutical residues are common in water sources.
Combined toxicity of polyethylene micro/nanoplastics and PFOA in zebrafish (Danio rerio): Impacts on antioxidant, neurotransmission, and gut microbiota
Researchers exposed zebrafish to polyethylene micro/nanoplastics and the industrial pollutant PFOA individually and in combination, assessing antioxidant capacity, neurotransmission, and gut microbiome composition. Combined exposure caused greater oxidative stress, more severe neurotransmitter disruption, and larger gut microbiome shifts than either contaminant alone, highlighting synergistic risks of co-occurring plastic and PFAS pollution.
Combined effects of high-fat diet and polystyrene microplastic exposure on microplastic bioaccumulation and lipid metabolism in zebrafish
Researchers studied how a high-fat diet combined with polystyrene microplastic exposure affects zebrafish, finding that obese fish accumulated significantly more microplastics in their tissues. The high-fat diet disrupted lipid metabolism and created conditions that increased microplastic retention in the body. This suggests that diet and body fat levels may influence how much microplastic accumulates in living organisms, with potential implications for human health.
Toxic Effects of Polystyrene Microplastics and Sulfamethoxazole on Early Neurodevelopment in Embryo–Larval Zebrafish (Danio rerio)
Researchers exposed embryo-larval zebrafish to polystyrene microplastics and the antibiotic sulfamethoxazole to assess their individual and combined effects on early neurodevelopment. The study found that both contaminants individually caused neurodevelopmental toxicity, and their combination produced a significant synergistic effect, suggesting that co-exposure to microplastics and antibiotics may pose greater risks than either pollutant alone.
Nanoplastic contamination: Impact on zebrafish liver metabolism and implications for aquatic environmental health
Zebrafish exposed to polystyrene nanoparticles for 28 days showed significant disruptions in liver metabolism, including altered fat processing, signs of inflammation, oxidative stress, and DNA damage. Notably, at lower doses the liver's detox enzymes appeared to break down the nanoplastics themselves, while higher doses overwhelmed these defenses and caused more severe injury.
Metabolic profile changes of zebrafish larvae in the single- and co-exposures of microplastics and phenanthrene
Researchers exposed zebrafish larvae to microplastics and the pollutant phenanthrene, both individually and together, and analyzed changes in their metabolic profiles. They found that combined exposure triggered unique metabolic disruptions not seen with either contaminant alone, particularly in amino acid metabolism pathways. The study provides evidence that microplastics and organic pollutants can interact to produce novel toxic effects in aquatic organisms.
Polystyrene modulation of perfluorooctanoic acid toxicity in zebrafish: Transcriptomic and toxicological insights
Researchers exposed zebrafish to the industrial chemical PFOA both alone and in combination with polystyrene microplastics of different sizes to understand how the particles influence chemical toxicity. They found that PFOA disrupted neurotransmitter pathways, and the addition of microplastics modified this toxicity in a size-dependent manner, with smaller particles generally increasing harmful effects. The study provides evidence that microplastics can alter how other environmental pollutants affect living organisms.
Polystyrene microplastics (PS-MPs) harness copper presence and promote impairments in early zebrafish (Danio rerio) larvae: Developmental, biochemical, transcriptomic approaches and nontargeted metabolomics approaches
This zebrafish study found that polystyrene microplastics combined with copper produced worse toxic effects than either pollutant alone, causing developmental problems, oxidative stress, immune disruption, and nerve damage in larvae. The combination also disrupted the fish's metabolism in ways that neither pollutant caused independently. This is concerning because microplastics readily absorb heavy metals like copper in the environment, meaning organisms are often exposed to both together.
Synergistic neurotoxicity of polystyrene nanoparticles and MEHP in zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene nanoparticles and MEHP (a phthalate plasticizer breakdown product) individually and in combination, finding synergistic neurotoxicity in co-exposed larvae driven by oxidative stress that disrupted glycerophospholipid metabolism and cholinergic neurotransmitter synthesis — with combined exposure amplifying bioaccumulation and embryonic cell death beyond what either pollutant caused alone.
Toxicity evaluation of the combination of emerging pollutants with polyethylene microplastics in zebrafish: Perspective study of genotoxicity, mutagenicity, and redox unbalance
Researchers exposed adult zebrafish to polyethylene microplastics combined with a mixture of common water pollutants for 15 days and assessed DNA damage, mutation rates, and oxidative stress. They found that microplastics alone caused DNA damage and nuclear abnormalities as severe as those caused by the pollutant mixture, challenging the assumption that microplastics are less harmful than chemical contaminants. The study revealed that the fish's antioxidant defenses were overwhelmed across multiple organs, suggesting widespread oxidative damage from microplastic exposure.
Combined effects of microplastics and chemical contaminants on the organ toxicity of zebrafish ( Danio rerio )
Researchers studied the combined effects of microplastics and chemical contaminants like PCBs and methylmercury on zebrafish organs over three weeks of exposure. They found that microplastics carrying adsorbed contaminants produced the most significant effects, particularly on the liver, compared to either microplastics or contaminants alone. The results indicate that microplastics may act as carriers that increase the delivery of harmful chemicals to organisms' tissues.