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61,005 resultsShowing papers similar to Exploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis
ClearThe Footprint of Microbiome in Pediatric Asthma—A Complex Puzzle for a Balanced Development
This review examines the growing body of evidence linking the human microbiome to the development of pediatric asthma. Researchers found that the composition of bacteria in the gut and respiratory tract during early childhood appears to influence whether children develop asthma. The study suggests that understanding these microbial patterns could open new approaches for preventing or managing asthma in children.
A probiotic for preventing microplastic toxicity: Clostridium dalinum mitigates microplastic-induced damage via microbiota-metabolism-barrier interactions
Using metagenomics and metabolomics, this study found that the probiotic bacterium Clostridium dalinum reduced microplastic-induced gut damage in mice by modulating gut microbiota composition, metabolic pathways, and intestinal barrier integrity.
Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This review examined the emerging mechanisms by which microplastics may contribute to skin diseases through the gut-skin axis. Researchers found evidence that microplastics can induce gut microbiota dysbiosis and compromise intestinal barrier integrity, which in turn may impair skin barrier function and trigger inflammatory skin conditions through shared immunological and neuroendocrine pathways.
Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This review examined the emerging mechanisms by which microplastics may contribute to skin diseases through the gut-skin axis. Researchers found evidence that microplastics can induce gut microbiota dysbiosis and compromise intestinal barrier integrity, which in turn may impair skin barrier function and trigger inflammatory skin conditions through shared immunological and neuroendocrine pathways.
Deciphering Microbiome, Transcriptome, and Metabolic Interactions in the Presence of Probiotic Lactobacillus acidophilus against Salmonella Typhimurium in a Murine Model
Researchers tested whether the probiotic Lactobacillus acidophilus could protect mice against Salmonella Typhimurium infection by examining changes in gut bacteria, gene expression, and metabolic pathways. They found that probiotic treatment improved gut microbial balance, reduced harmful bacterial load, and modulated immune and metabolic responses. The study suggests that probiotics may offer a promising alternative strategy to antibiotics for managing certain foodborne bacterial infections.
Maternal and early life exposures and their potential to influence development of the microbiome
This review explores how maternal and early-life environmental exposures, including to emerging contaminants, can influence the development of the infant microbiome. Researchers found that factors such as nutrition, chemical exposures, and living conditions during pregnancy and early childhood shape the microbial communities that are critical for immune and metabolic development. The study highlights the importance of understanding how environmental pollutants may disrupt healthy microbiome establishment in vulnerable populations.
Microplastic-associated gut microbial profile and antibiotic resistance in preschool children: a multicentre cross-sectional study in China
In a multicentre study of 335 preschool children across three Chinese cities, researchers detected eight types of microplastics in fecal samples at a median concentration of 212.1 micrograms per gram. The study found that microplastic exposure was associated with changes in gut microbiota composition and function, including metabolic pathways related to macronutrients and vitamins, as well as a relationship with antibiotic resistance gene abundance.
Association between the skin microbiome and MHC class II diversity in an amphibian
Researchers examined how genetic background and MHC class II diversity shape the skin microbiome of amphibians, finding that host genotype influences microbial community composition in ways that may affect disease resistance and environmental adaptation.
Novel functional insights into the microbiome inhabiting marine plastic debris: critical considerations to counteract the challenges of thin biofilms using multi-omics and comparative metaproteomics.
Researchers developed a comprehensive metaproteomics approach to study the microbial communities living on the surface of marine plastic debris, known as the plastisphere. The study reveals how microbes on plastic interact with each other and their environment, with implications for understanding how plastic-colonizing bacteria spread through the ocean.
Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence
Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.
Integrated Analysis of the Transcriptome and Microbial Diversity in the Intestine of Miniature Pig Obesity Model
Researchers fed miniature pigs a high-fat, high-carbohydrate diet for 26 weeks and compared their gut health to pigs on a normal diet. The obesity-prone pigs showed increased inflammation, disrupted blood sugar metabolism, and significant declines in beneficial gut bacteria. The study reveals strong connections between diet-induced gut microbial changes and immune-related gene expression in the intestines.
The Human Archaeome: Commensals, Opportunists, or Emerging Pathogens?
This review examines the human archaeome—archaeal microorganisms inhabiting the gut, skin, and other body sites—and their potential roles in health and disease. It finds no conclusive archaeal pathogens in humans but identifies indirect roles through metabolic interactions with bacteria, relevant to gut microbiome research.
Probiotics as Modulators of Microplastic-induced Toxicity: A Systematic Review
This systematic review found that probiotics can reduce microplastic-induced toxicity in animal models by restoring gut microbiota balance, reducing oxidative stress, and modulating inflammatory responses. The findings suggest that probiotic supplementation may help mitigate the harmful effects of unavoidable microplastic exposure, though human clinical trials are still needed.
Integrating Metagenomics and Immunoinformatics to Prioritize Antigens and Immune-Modulating Molecules from Environmental Microbiomes
Researchers explored how combining metagenomic sequencing of environmental microbiomes with computational immunology tools can identify microbial proteins and metabolites that modulate immunity. The study describes workflows that screen metagenome-assembled genomes from soil, water, and microplastic-associated biofilms to predict potential antigens and immune-stimulating molecules. The findings suggest this integrated approach could accelerate discovery of novel immune-modulating compounds from environmental microorganisms.
Additional file 1 of Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This paper provides supplementary material for a review on microplastic-induced skin diseases through the gut-skin axis. The parent study examined how microplastics disrupt gut microbiota and intestinal barrier integrity, potentially contributing to inflammatory skin conditions via shared immune and neuroendocrine signaling.
Additional file 1 of Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This paper provides supplementary material for a review on microplastic-induced skin diseases through the gut-skin axis. The parent study examined how microplastics disrupt gut microbiota and intestinal barrier integrity, potentially contributing to inflammatory skin conditions via shared immune and neuroendocrine signaling.
Anatomically-specific coupling between innate immune gene repertoire and microbiome structure during coral evolution
This study found that different coral species have distinct coupling between their immune gene repertoires and microbiome composition, suggesting evolutionary specialization of host-microbe relationships. Coral microbiomes are being disrupted by plastic pollution, making understanding baseline coral immunity relevant to assessing plastic pollution impacts on reef health.
Causal relationship between gut microbiota and gastrointestinal diseases: a mendelian randomization study
This Mendelian randomization study found genetic evidence supporting a causal relationship between specific gut microbiota compositions and gastrointestinal diseases. The findings suggest that microbiome-related interventions, including microbiome-dependent metabolites, could potentially be developed to treat or manage gastrointestinal conditions.
Global trends and hotspots of gastrointestinal microbiome and toxicity based on bibliometrics
This bibliometric analysis mapped global research trends and hotspots in gastrointestinal microbiome and toxicity studies, finding that modifications to the gut microbiome could offer new directions for treating and mitigating toxic exposures.
Comparative whole-genome approach to identify bacterial traits for microbial interactions
A genome-based trait analysis of 473 marine bacterial species was developed to systematically map the functional and interaction potential of marine microbial communities. The findings advance understanding of how marine bacteria function, with relevance to how microbial communities respond to plastic pollution in the ocean.
Association between microplastics and the functionalities of human gut microbiome
Researchers measured five types of microplastics in the blood of 39 adults and then analyzed their gut bacteria using advanced genetic sequencing. They found that microplastic exposure was linked to changes in gut bacteria that could promote infection, including increases in genes related to bacterial invasion and communication. This is one of the first studies to connect microplastic levels in human blood with functional changes in the gut microbiome, suggesting a mechanism by which microplastics could affect overall health.
Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut–skin axis
This review explores how microplastics may cause skin damage through the gut-skin axis, a system connecting intestinal and skin health through immunological and neuroendocrine pathways. The study suggests that microplastics can disrupt gut microbial balance and intestinal barrier integrity, allowing harmful bacteria and metabolites to enter the bloodstream and contribute to skin inflammation, metabolic imbalance, and oxidative stress.
Investigating the interplay of the immune system, skin barrier, and microbiome following dermal exposure to triclosan
This study investigated how triclosan, an antimicrobial chemical in skin care products, disrupts the skin barrier, skin microbiome, and immune system following direct skin exposure in mice. Triclosan exposure has been linked to increased allergy and asthma risk in humans, and understanding its mechanism is relevant to evaluating safety of chemicals in personal care products.
Novel functional insights into the microbiome inhabiting marine plastic debris: critical considerations to counteract the challenges of thin biofilms using multi-omics and comparative metaproteomics
Researchers used advanced multi-omics techniques — simultaneously analyzing the DNA, proteins, and metabolic activity of microbes — to study the complex communities of bacteria and other microorganisms that colonize marine plastic debris (the "plastisphere"). The work reveals new ecological functions of these microbial films beyond plastic breakdown, including potential biotechnology applications and risks from pathogen hitchhiking on ocean plastic.