We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Association between microplastics and the functionalities of human gut microbiome
Summary
Researchers measured five types of microplastics in the blood of 39 adults and then analyzed their gut bacteria using advanced genetic sequencing. They found that microplastic exposure was linked to changes in gut bacteria that could promote infection, including increases in genes related to bacterial invasion and communication. This is one of the first studies to connect microplastic levels in human blood with functional changes in the gut microbiome, suggesting a mechanism by which microplastics could affect overall health.
As an integral part of humans, the gut microbiome plays a significant role in the physiological and pathological processes of the host, and dysbiosis of the gut microbiome is linked to various diseases. The impact of microplastics on the diversity and composition of human gut microbiome has been reported previously. However, effects of microplastics on the functionality of the gut microbiome in humans have not been well studied. In the present study, concentrations of microplastics in human blood were detected through pyrolysis-gas chromatography/mass spectrometry in 39 adults. Five types of microplastics were found in human blood, including polyvinyl chloride, polyethylene, polypropylene, polystyrene, and polyamide 66. Shotgun metagenomic sequencing was further employed to analyze the metagenomes of the human stool samples and fecal samples from mice exposed to microplastics. Associations were found between microplastics and microbial species, as well as microbial genes encoding invasion-related virulence factors, quorum sensing, autoinducer and transporter system, and microplastic biodegradation enzymes. The findings are of significance to improve the understanding of functional changes in the gut microbiome associated with microplastic exposure, as well as raising awareness regarding the health risks of microplastics in the human population.