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20 resultsShowing papers similar to Polybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology
ClearPolybiome Systems Medicine: Conceptual Architecture, Methodological Foundations, and Translational Applications — Volume I: Vision and Foundational Methodology
This foundational document presents the Polybiome Systems Medicine framework, proposing that the human organism is a co-constructed biological consortium shaped by host genomics, multi-kingdom microbiomes, environmental exposures, and immune networks. The framework incorporates environmental factors including microplastics and endocrine disruptors as modulators of human health. The authors outline a five-layer architecture designed to integrate diverse biological data for a more holistic approach to medicine.
The exposome paradigm to predict environmental health in terms of systemic homeostasis and resource balance based on NMR data science
This paper proposes an exposome framework for predicting environmental health based on systemic homeostasis, integrating data from microbial ecosystems, chemical exposures, and recycled resources to evaluate environmental illness. The approach aims to model how combined exposures disrupt biological balance in organisms and ecosystems.
The “Microplastome” – A Holistic Perspective to Capture the Real-World Ecology of Microplastics
This paper introduces the concept of the "microplastome," a framework for studying microplastics along with everything attached to them, including absorbed chemicals and colonizing microbes, as a unified system. The authors argue that current research too often looks at microplastics in isolation, when in reality the attached pollutants and bacteria may be just as important for understanding health effects. This more complete approach could lead to better risk assessments of how microplastic pollution actually affects ecosystems and human health.
The Human Plastiphere:A Bioparticulate System ChallengingMicroplastic Risk Assessment and Governance
Drawing on 90 clinical studies from 2016–2025, researchers defined the 'human plastiphere' — the system of non-endogenous plastic particles that accumulate, distribute, and interact with human tissues — and proposed a framework for assessing its health risks. The review mapped MP accumulation in over a dozen tissue types and identified mechanisms of cellular and organ-level harm.
Die Bedeutung der Konzepte One Health und Planetary Health für die Umweltmedizin im 21. Jahrhundert
This review examined how One Health and Planetary Health frameworks are essential for 21st-century environmental medicine, emphasizing the interconnected threats from chemical pollutants, microplastics, and climate change to both human and ecosystem health.
Planetary Health: Safeguarding Human Health and the Environment in the Anthropocene
This book on Planetary Health framed environmental degradation as a direct threat to human health across domains from pandemics to chronic disease to mental health, arguing that transformative changes in energy, food, housing, and transport systems are needed to simultaneously improve health outcomes and protect the natural systems on which human civilization depends.
The Micronanoplastics-immune axis across organ systems: towards a research agenda
This review synthesizes current evidence on how micro- and nanoplastics interact with the immune system across multiple organ systems in the human body. Researchers examined the primary routes of exposure through inhalation, ingestion, and dermal contact, as well as the cellular mechanisms involved in immune response. The study highlights that microplastic-immune interactions may contribute to chronic inflammation and immune dysregulation, pointing to a need for standardized research frameworks.
The Human Plastiphere: A Bioparticulate System Challenging Microplastic Risk Assessment and Governance
This paper introduces the concept of the "human plastiphere," a system of plastic particles that accumulate and persist in human tissues across 63 different body compartments, based on a review of 90 clinical studies. The authors identify eight unresolved scientific puzzles, including how tiny particles cross biological barriers they should not be able to penetrate, and the absence of any known safe threshold for exposure. The framework calls for standardized detection methods and polymer-specific safety limits to better protect human health as plastic production continues to rise.
Exploring the Exposome Spectrum: Unveiling Endogenous and Exogenous Factors in Non-Communicable Chronic Diseases
This review explores the concept of the exposome -- the total of all environmental exposures a person encounters throughout their lifetime, including chemical pollutants, microplastics, air pollution, and stress. It highlights how these combined exposures interact to drive chronic diseases like cancer, heart disease, and diabetes, emphasizing that microplastics are one piece of a larger puzzle of environmental health threats.
Microplastics in human body: accumulation, natural clearance, and biomedical detoxification strategies
This review summarises how microplastics enter and accumulate in the human body through air, water, and food, and critically assesses the limited evidence on natural clearance mechanisms including excretion and immune clearance. It also evaluates emerging biomedical strategies—such as chelation-inspired and microbiome-based approaches—for enhancing microplastic removal from tissues.
Interactions between microplastics and microbiota in a One Health perspective
This review examines how microplastics interact with microbial communities across human, animal, and environmental settings using a One Health framework. Microplastics disrupt the normal balance of microbiota in the gut, soil, and water, and serve as surfaces where harmful bacteria and antibiotic resistance genes accumulate and spread. The authors argue that understanding these microplastic-microbe interactions across all domains of life is essential for protecting both ecosystem and human health.
The ocean and microplastics: a One Health approach
This paper examines ocean microplastic pollution through a One Health framework, connecting marine ecosystem contamination to animal and human health impacts by tracing microplastic pathways from ocean sources through food webs to human exposure. The approach integrates ecological, veterinary, and public health perspectives to argue for a unified response to microplastic pollution as a cross-cutting environmental health challenge.
A roadmap for a Plastisphere
This paper discusses the concept of the 'Plastisphere'—the total surface area of plastic debris in the environment that hosts unique microbial communities. The author reviews current knowledge and outlines a research roadmap for understanding how the Plastisphere affects ecosystem function and potentially human health through the spread of pathogens and antibiotic resistance.
Tackling the microplastics pandemic: the CLEAN framework as an integrated one health approach for global environmental and public health
This paper introduces the CLEAN framework as an integrated One Health approach for addressing microplastic pollution across environmental, animal, and human health domains. Researchers argue that current responses to microplastic contamination are fragmented and propose a systematic risk assessment and prevention strategy analogous to occupational health management. The framework aims to bridge gaps between environmental science, public health policy, and community-level action on microplastic exposure.
Impact of Microplastic Exposure on Human Health: A Systematic Review of Mechanisms, Biomarkers, and Clinical Outcomes
This systematic review found that microplastics have been detected in human blood, placental tissue, and gastrointestinal samples, with proposed health mechanisms including oxidative stress, chronic inflammation, endocrine disruption, and gut microbiome alterations. While direct clinical evidence remains limited, the accumulating laboratory and observational data point to microplastics as a plausible contributor to multiple disease pathways.
Effect of altered human exposome on the skin and mucosal epithelial barrier integrity.
This review examined how modern environmental exposures including microplastics, air pollutants, and chemical toxicants disrupt the epithelial barrier integrity of skin and mucous membranes, arguing that the 'exposome' of chronic low-level chemical exposures is a major but underappreciated driver of barrier dysfunction and associated inflammatory diseases.
Microplastics in Humans: A Critical Review of Biomonitoring Evidence and Immune–Metabolic Associations
This review critically evaluates the current evidence on microplastic detection in human tissues and biological fluids, focusing on methodological challenges and the potential biological mechanisms of action. Researchers found significant variation across studies due to differences in analytical techniques and sample handling protocols. The study highlights emerging evidence linking microplastic presence in the body to immune and metabolic disruptions, while noting that standardized detection methods are urgently needed.
Aquatic one health framework: Integrating ocean ecosystems and human well-being
This paper introduces an Aquatic One Health framework that integrates ocean ecosystem health with human and animal wellbeing, discussing how marine pollutants including microplastics form interconnected threats that require coordinated environmental and public health responses.
[Clinical impact of microplastic exposure in humans].
This review summarized clinical evidence on the health impacts of microplastic exposure in humans, covering routes of entry (air, food, contact) and the range of organ systems affected. It concluded that while data are still emerging, current evidence supports concern about microplastic accumulation and its potential to cause inflammation, oxidative stress, and systemic health effects.
Facing stress and inflammation: From the cell to the planet.
This review examines stress and inflammation as interconnected biological responses at scales from the cell to the whole planet, tracing how environmental stressors including pollution drive inflammatory disease. The paper positions microplastic contamination and other anthropogenic pollutants as systemic stressors that may be contributing to rising rates of chronic inflammatory conditions.