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61,005 resultsShowing papers similar to A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals
ClearRole of Mitochondria in Inflammatory Bowel Diseases: A Systematic Review
This systematic review found that mitochondrial dysfunction plays a significant role in inflammatory bowel diseases through multiple mechanisms, including disrupted energy production, impaired mucosal repair, altered gut microbiota signaling, and weakened intestinal barrier integrity. The findings are relevant to microplastic research because plastic particle exposure has been shown to cause mitochondrial damage in gut tissues.
Mitochondria-Targeted Biomaterials-Regulating Macrophage Polarization Opens New Perspectives for Disease Treatment
This review explores how new biomaterials can be designed to target mitochondria inside immune cells called macrophages, steering them between pro-inflammatory and anti-inflammatory states to treat diseases. While not directly about microplastics, the review is relevant because microplastic exposure is known to cause mitochondrial damage and trigger inflammatory immune responses through these same pathways. Understanding how to control macrophage behavior through mitochondria could lead to treatments for inflammation caused by environmental pollutants like microplastics.
The Mitochondrial Battleground: A Review of Microplastic-Induced Oxidative Stress and Inflammatory Pathways in Human Health
This review synthesizes research on how microplastics damage mitochondria through oxidative stress and inflammation across aquatic, terrestrial, and mammalian systems. Researchers found that microplastics generate reactive oxygen species that disrupt mitochondrial function, with smaller and aged particles causing greater toxicity, while inflammatory signaling creates a feedback loop that worsens cellular damage.
Hypoxia is a key mechanism for regulating inflammation in ulcerative colitis
This review examines how tissue hypoxia regulates inflammation in ulcerative colitis, a chronic bowel disease. While not directly about microplastics, it is relevant because microplastic exposure has been associated with gut inflammation and disruption of the intestinal barrier in emerging research.
Assessing micro and nanoplastics toxicity using rodent models: Investigating potential mitochondrial implications
This review examines recent rodent studies investigating how micro- and nanoplastics affect cellular health, with a focus on potential mitochondrial impacts. Researchers found that while no study has directly targeted mitochondrial effects, several reported molecular and biochemical changes consistent with disrupted mitochondrial function, including oxidative stress. The study suggests that mitochondria may be an important but understudied target of micro- and nanoplastic toxicity.
The detrimental effects of micro-and nano-plastics on digestive system: An overview of oxidative stress-related adverse outcome pathway
This review maps out how micro and nanoplastics damage the digestive system, identifying oxidative stress as the initial trigger that leads to inflammation, cell death, disrupted gut bacteria, and metabolic disorders. The authors use an adverse outcome pathway framework to connect molecular-level damage to broader health consequences. The findings suggest that ongoing microplastic exposure through food and water could contribute to digestive health problems.
Impact of micro- and nanoplastics on gastrointestinal diseases: Recent advances
This review summarizes how micro- and nanoplastics can harm the digestive system by causing oxidative stress, inflammation, cell death, and disruption of gut bacteria. These connected pathways can damage the intestinal lining and may contribute to conditions like inflammatory bowel disease and colorectal cancer. The findings highlight the importance of understanding how everyday plastic exposure through food and water could affect gut health over time.
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
This study found that rosmarinic acid, a natural plant compound, protected mice from intestinal inflammation by restoring healthy gut bacteria and reducing cell stress and damage. While not directly about microplastics, the research is relevant because microplastics are known to cause similar gut inflammation and disrupt the gut microbiome. Understanding how natural compounds can repair gut damage may help develop strategies to counteract the harmful effects of microplastic exposure on digestive health.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review of 30 in vitro studies found that microplastics and nanoplastics cause size- and concentration-dependent damage to human gastrointestinal cells, including increased oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Smaller particles consistently showed greater cellular uptake and biological effects, though chronic low-dose exposure generally produced minimal impacts.
Influence of Micro- and Nanoplastics on Mitochondrial Function in the Cardiovascular System: A Review of the Current Literature
This review examined the limited but growing research on how micro- and nanoplastics may affect mitochondrial function in the cardiovascular system. Researchers noted that these plastic particles can trigger oxidative stress and disrupt normal mitochondrial processes, which are critical for heart and blood vessel health. The study highlights the need for more comprehensive research given the rising levels of plastic particle contamination and the importance of mitochondrial health in preventing cardiovascular problems.
Protocatechuic Acid Alleviates Dextran-Sulfate-Sodium-Induced Ulcerative Colitis in Mice via the Regulation of Intestinal Flora and Ferroptosis
Researchers found that protocatechuic acid, a naturally occurring compound found in many fruits and vegetables, helped alleviate ulcerative colitis in mice by restoring healthy gut bacteria and reducing a type of cell death called ferroptosis. The treatment improved intestinal barrier integrity and reduced inflammation. This is relevant to microplastics research because gut barrier damage is a key concern with microplastic ingestion.
Impact of Micro- and Nanoplastics on Mitochondria
This review examines how micro- and nanoplastics can damage mitochondria, the energy-producing structures inside cells that are critical for metabolism and cell survival. Researchers found that plastic particle exposure can trigger oxidative stress, disrupt mitochondrial membrane function, and interfere with energy production pathways. Since mitochondrial dysfunction is linked to numerous health conditions, the study suggests this may be a key mechanism through which plastic pollution affects human health.
Mitochondria as a target of micro- and nanoplastic toxicity
This review examines how micro- and nanoplastics damage mitochondria, the energy-producing structures inside our cells. Research shows these tiny plastic particles can cross biological barriers, enter cells, and disrupt mitochondrial function by triggering oxidative stress and altering energy production. Since mitochondrial damage is linked to diseases like cancer, diabetes, and neurodegeneration, this represents a key concern for human health.
Recommendation: Mitochondria as a target of micro- and nanoplastic toxicity — R0/PR2
This review focuses on mitochondria as a key target of micro- and nanoplastic toxicity, summarizing evidence that MPs and NPs trigger oxidative stress, disrupt mitochondrial membrane potential, alter fusion/fission dynamics, and activate mitophagy. Because mitochondrial dysfunction underlies neurodegenerative disease, diabetes, and cancer, this mechanistic framework helps explain why microplastic exposure may contribute to a wide range of serious human health conditions.
Anthocyanins as protectors of gut microbiota: mitigating the adverse effects of microplastic-induced disruption
This review examines how anthocyanins, bioactive compounds found in berries and other pigmented plants, may protect gut microbiota from disruption caused by microplastic exposure. Researchers synthesized evidence suggesting that anthocyanins counteract microplastic-induced oxidative stress and inflammation in the gut. The findings indicate that dietary anthocyanins could serve as a protective factor against the adverse effects of microplastics on digestive health.
The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications
This review examines how high blood sugar in diabetes triggers excessive production of reactive oxygen species (ROS) in mitochondria, leading to a destructive cycle of cellular damage that drives complications in the heart, kidneys, and blood vessels. While focused on diabetes, this mechanism is relevant to microplastic research because microplastics are also known to increase ROS production and mitochondrial dysfunction in human cells.
Mitigating microplastic-induced organ Damage: Mechanistic insights from the microplastic-macrophage axes
This review is the first comprehensive examination of how microplastics interact with macrophages, the immune cells responsible for engulfing and removing foreign particles from the body. When macrophages absorb microplastics, the resulting oxidative stress disrupts their normal function, leading to inflammation and organ damage, with gut bacteria potentially playing a role in this harmful process.
Orally Ingested Micro- and Nano-Plastics: A Hidden Driver of Inflammatory Bowel Disease and Colorectal Cancer.
This review synthesizes evidence linking ingested micro- and nano-plastics to inflammatory bowel disease and colorectal cancer risk, proposing that microplastics act as a hidden driver of gut inflammation in vulnerable populations. The authors argue that intestinal accumulation of microplastics triggers immune and oxidative stress pathways that contribute to disease progression.
Considering the Importance of Medicinal Plants and Natural Products and Their Mechanisms of Action for Treatment of Gastrointestinal Disorders
This bibliometric analysis of over a thousand articles reviewed medicinal plants and natural products for treating gastrointestinal disorders, highlighting their anti-inflammatory, antioxidant, and gut-protective mechanisms. While not focused on microplastics, the gut-protective properties of certain natural compounds are relevant to understanding how to mitigate gastrointestinal damage from environmental contaminants.
Microplastics/nanoplastics contribute to aging and age-related diseases: Mitochondrial dysfunction as a crucial role
This review examines how microplastics and nanoplastics may contribute to aging and age-related conditions by damaging mitochondria, the energy-producing structures inside cells. Researchers describe how these tiny plastic particles enter the body through food, water, and air, and accumulate in various organs where they can disrupt normal mitochondrial function. The study suggests that microplastic-driven mitochondrial damage could be an underappreciated factor in the aging process and related health decline.
The role of microplastics in the pathogenesis of inflammatory bowel diseases
This review of existing research found that tiny plastic particles we eat and drink may contribute to inflammatory bowel diseases like Crohn's disease and ulcerative colitis. The plastic bits can damage the gut lining, cause inflammation, and disrupt the healthy bacteria in our intestines. While more research is needed to confirm the connection, this suggests that reducing plastic pollution could be important for protecting our digestive health.
Mitochondria as a target of micro- and nanoplastic toxicity
This review examines how micro- and nanoplastics damage mitochondria, the energy-producing structures inside cells. Studies show that plastic particles can disrupt energy production, cause harmful oxidative stress, and interfere with the cell's ability to repair or recycle damaged mitochondria. Since mitochondrial damage is linked to many chronic diseases including heart disease, neurodegeneration, and diabetes, this helps explain why microplastic exposure may have widespread health effects.
Mitochondrial Complex I hyperactivation drives PET microplastic-induced intestinal bioenergetic collapse
Researchers found that PET microplastics derived from commercial bottles, after passing through simulated digestion, caused a cascade of metabolic damage in intestinal cells. The digested particles triggered hyperactivation of mitochondrial Complex I, leading to excessive free radical production, ATP shutdown, and oxidative stress. The study suggests that the digestive transformation of everyday PET plastics alters their surface properties in ways that make them more biologically harmful to gut cells.
Adipose tissue as target of environmental toxicants: focus on mitochondrial dysfunction and oxidative inflammation in metabolic dysfunction-associated steatotic liver disease
This review examines how environmental toxicants, including micro and nanoplastics, target fat tissue and contribute to metabolic diseases like obesity, diabetes, and fatty liver disease. These pollutants disrupt mitochondria (the energy-producing parts of cells) and trigger a cycle of oxidative stress and inflammation that damages both fat tissue and the liver. The findings suggest that microplastic exposure could be one of several environmental factors contributing to the rising rates of metabolic disease worldwide.