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61,005 resultsShowing papers similar to Role of microplastics in the tumor microenvironment (Review)
ClearFrom exposure to oncogenesis: a review on the multifaceted roles of microplastics in tumor initiation and progression
This review examined the evidence linking microplastic exposure to tumor initiation and progression, covering physical, chemical, and inflammatory mechanisms by which MPs may promote oncogenesis. The authors conclude that while current evidence is largely preclinical, accumulating data warrant serious concern about microplastics as environmental carcinogens.
Microplastics and cancer
This review examines evidence linking microplastics to cancer risk, noting that microplastics have been detected at higher concentrations in human tumor tissues than adjacent healthy tissue, and that they can act as vectors for carcinogens while inducing oxidative stress, inflammation, and genotoxicity.
Microscopic menace: exploring the link between microplastics and cancer pathogenesis
This review examines the growing evidence linking microplastic exposure to cancer development in humans. Microplastics can accumulate in the body and trigger inflammation, oxidative stress, and other biological changes associated with tumor growth. While more clinical research is needed, the review highlights that microplastics should be taken seriously as a potential factor in cancer risk.
Microplastics as emerging carcinogens: from environmental pollutants to oncogenic drivers
This review examines growing evidence that microplastics and nanoplastics may play a role in cancer development, with these particles found in human tumor tissues from the lungs, colon, stomach, breast, and other organs. The particles appear to promote cancer through chronic inflammation, oxidative stress, DNA damage, and disruption of key cancer-related signaling pathways. While direct proof of causation in humans is still lacking, the accumulating evidence from lab studies, animal experiments, and human tissue analysis suggests microplastics deserve serious attention as potential contributors to cancer risk.
The micro(nano)plastics perspective: exploring cancer development and therapy
This review explores the emerging link between microplastics and cancer development. Microplastics can trigger chronic inflammation, oxidative stress, and hormone disruption, all of which are known pathways that may promote cancer growth. Interestingly, researchers are also studying whether engineered microplastics could be used as drug carriers for cancer therapy, though long-term effects remain unclear.
From Exposure to Oncogenesis: the Role of Microplastics and Associated Pollutants in Cancer - a Literature Review
This literature review examined the growing evidence linking microplastic exposure to cancer development. Microplastics have been found in human lung, liver, and colon tissue, and research suggests they may promote cancer through chronic inflammation, oxidative stress, and by carrying known carcinogens like heavy metals and persistent organic pollutants into the body.
Microplastics and Nanoplastics in Cancer Progression: Biology and Public Health
This review examines emerging evidence that microplastics and nanoplastics may contribute to cancer-related processes by crossing biological barriers and accumulating in tissues. The study highlights that these particles can cause oxidative stress, inflammation, DNA damage, and barrier dysfunction at the cellular level, and may promote tumor-supporting processes including angiogenesis and immune evasion.
Microplastics: an often-overlooked issue in the transition from chronic inflammation to cancer
This review explores how microplastics that accumulate in the human body may trigger long-lasting inflammation, which is a known driver of cancer development. The authors describe how microplastics can disrupt the gut microbiome, activate immune responses, and alter signaling pathways in ways that could promote tumor growth over time.
Evaluating the relationship between microplastics and nanoplastics contamination and diverse cancer types development
This review examines growing evidence that micro- and nanoplastics found in human tissues may contribute to cancer development through several pathways. These tiny particles can generate harmful molecules called reactive oxygen species, cause chronic inflammation, and disrupt cell growth signals, all of which are known to promote cancer. While long-term, high-level exposure likely poses the greatest risk, more research is needed to understand the full cancer-related dangers of microplastic exposure.
Detection and quantification of microplastics in various types of human tumor tissues
Researchers detected microplastics in 43% of tumor samples across lung, gastric, colorectal, cervical, and pancreatic cancers, with polystyrene, PVC, and polyethylene being the types found. In pancreatic tumors, microplastic presence was associated with fewer immune cells that fight cancer and more immune cells linked to tumor progression, suggesting microplastics may create conditions that help tumors evade the immune system.
Microplastics and Cancer: A Comprehensive Review of Their Impact on Tumor Progression and Mechanisms of Carcinogenesis
This comprehensive review examines the growing body of evidence linking microplastic exposure to various types of cancer, including colorectal, lung, liver, and breast cancers. Researchers found that microplastics and nanoplastics may promote tumor progression through mechanisms including oxidative stress, chronic inflammation, and disruption of cellular signaling pathways. While the evidence is still emerging, the study highlights the need for further research into the potential cancer-related risks of widespread microplastic exposure.
The Relationship Between Microplastics and Nanoplastics with Cancer: An Emerging Health Concern
This review explores the emerging relationship between micro- and nanoplastic exposure and cancer risk in humans. Researchers summarized evidence suggesting that microplastics can carry carcinogenic substances and may trigger inflammatory and oxidative stress pathways linked to tumor development. The study highlights that while early evidence raises concern, more research is needed to establish clear causal connections between plastic particle exposure and specific cancer types.
Microplastics and Colorectal Cancer: Presence in Human Colorectal Tissues and Associations with Tumor Biology- A Systematic Review
This review of 13 studies found that tiny plastic particles called microplastics are present in human colon tissues, with higher amounts found in cancerous tumors compared to healthy tissue. The research suggests these plastic particles may contribute to colon cancer development by causing inflammation and creating conditions that help tumors grow. While more research is needed to prove a direct cause-and-effect relationship, this highlights growing concerns about how plastic pollution in our environment and food supply might affect human health.
The Impact of Environmental Factors on Cancer Risk: A Comprehensive Review
This paper is not about microplastics in a specific research sense; it is a broad review of how environmental factors influence cancer risk, with no substantive microplastic content evident from the available abstract.
Plastic pollution-Microplastics: Cancer related issues
This review examines how microplastics may contribute to cancer risk, summarizing evidence that ingested microplastics can cross the gut epithelium, accumulate in tissues, induce oxidative stress and inflammation, and carry carcinogenic chemical additives.
The hidden poison - microplastic : Inflammatory catalyst of cancer development
This review discusses how microplastics act as inflammatory agents within biological tissues, summarizing evidence that ingested and inhaled microplastics can trigger oxidative stress, immune responses, and chronic inflammation in humans and animals.
Micro(nano)plastics pollution and human health: How plastics can induce carcinogenesis to humans?
This review examines how microplastics and nanoplastics enter the human body through food, water, and air, and how they may contribute to cancer development. Common plastic types like polystyrene and PVC, along with toxic chemicals they carry such as PAHs and PCBs, have been linked to DNA damage, oxidative stress, and inflammation, all of which can promote cancer. The paper highlights that while the evidence is growing, more research is needed to understand the full cancer risk from chronic microplastic exposure.
The hidden threat: Microplastics and cancer biology
This review synthesizes current research on the potential links between micro- and nanoplastic exposure and cancer biology, examining how these particles may contribute to tumor development in organs including the gut, lungs, skin, liver, kidney, and brain. The study suggests that chronic exposure to plastic particles can trigger molecular changes such as oxidative stress, inflammation, and DNA damage that are associated with cancer initiation, though clear causal evidence in humans is still lacking.
The alarming link between environmental microplastics and health hazards with special emphasis on cancer
This review describes how microplastics enter the human body through the nose, skin, and mouth, then penetrate cells where they can alter gene expression, fuel inflammation, disrupt hormone signaling, and promote uncontrolled cell growth. Studies have linked microplastic exposure to cancers of the lungs, blood, breast, prostate, and ovaries, though the precise molecular mechanisms still need further investigation.
Microplastic Contamination: A Rising Environmental Crisis With Potential Oncogenic Implications
This review examines how microplastics detected in human tissues — blood, placenta, and organs — may act as vectors for carcinogens, including adsorbed heavy metals and persistent organic pollutants, and discusses emerging evidence linking MP accumulation to oncogenic processes.
Microplastics: An emerging environmental risk factor for gut microbiota dysbiosis and cancer development?
This review examines how microplastics may disrupt the gut microbiome and immune system in ways that could promote cancer development. Evidence from recent studies suggests microplastics can cause chronic inflammation, alter the balance of gut bacteria, and trigger molecular pathways linked to several cancer types including lung, liver, breast, and colon cancer. While more human research is needed, the review highlights a concerning connection between microplastic exposure, gut health, and cancer risk.
Identification and analysis of microplastics in para-tumor and tumor of human prostate
Researchers detected microplastics in both tumor and surrounding tissue from 22 prostate cancer patients, with polystyrene found exclusively in tumor tissue. Larger microplastic particles were more common in tumors, and higher microplastic levels correlated with more advanced cancer stages, suggesting a potential link between microplastic accumulation and prostate cancer progression.
Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms
This review describes how microplastics smaller than 5 mm can enter human cells and promote cancer development through multiple pathways, including DNA damage, oxidative stress, chronic inflammation, and disruption of cell growth controls. Microplastics also carry other contaminants into the body, and their accumulation in tissues raises concerns about long-term cancer risk, particularly in the lungs, skin, and digestive system.
Environmental Pollution and Breast Cancer: The Microplastic Component BPA Regulates the Intratumoral Immune Microenvironment and Increases Lung Metastasis
Bisphenol A (BPA), a chemical found in many plastics, was shown to alter the immune environment within breast tumors and increase lung metastasis in mice. The findings suggest that BPA exposure may worsen cancer outcomes by promoting spread of the disease.