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61,005 resultsShowing papers similar to Nobiletin‐mediated autophagy mitigates nanoplastic‐induced toxicity in human intestinal Caco‐2 cells
ClearNobiletin Ameliorates Aging of Chicken Ovarian Prehierarchical Follicles by Suppressing Oxidative Stress and Promoting Autophagy
This study investigated a plant compound called nobiletin (found in citrus fruits) as a treatment for age-related decline in chicken egg production caused by follicle aging. While focused on poultry science rather than microplastics, the research is relevant because it demonstrates how antioxidants can counteract oxidative stress and mitochondrial damage -- the same types of cellular harm that microplastics and nanoplastics have been shown to cause in various tissues.
The impact of nanomaterials on autophagy across health and disease conditions
Researchers examined how nanomaterials — including nanoplastics — interact with autophagy, the cell's internal recycling and cleanup system. Depending on the type and dose, nanoplastics can either trigger helpful cellular defense responses or push cells toward self-destruction, a dual nature that has important implications for both environmental health and the design of nanomaterial-based medicines.
Biological Modulation of Autophagy by Nanoplastics: A Current Overview
This review examines how nanoplastics interfere with autophagy, the cell's natural recycling and cleanup process. While cells initially activate autophagy to deal with nanoplastic particles, prolonged exposure can overwhelm this system, leading to cell damage and death. Understanding this process is important because it may explain how long-term nanoplastic exposure contributes to tissue damage and disease in humans.
Maltol attenuates polystyrene nanoplastic-induced enterotoxicity by promoting AMPK/mTOR/TFEB-mediated autophagy and modulating gut microbiota
Researchers found that maltol, a natural food flavoring compound, can protect against intestinal damage caused by polystyrene nanoplastics in mice. Maltol worked by activating cellular cleanup processes (autophagy) and restoring the balance of gut bacteria disrupted by nanoplastic exposure. The study suggests that dietary compounds like maltol could potentially help mitigate some of the gut health effects associated with nanoplastic ingestion.
Protective effects of exocarpium citri grandis extract and its flavonoid components against polystyrene microplastic-induced hepatointestinal injury
Scientists found that an extract from citrus fruit peels (called ECG) helped protect mice from liver and gut damage caused by tiny plastic particles. The citrus extract reduced harmful inflammation and oxidative stress while improving healthy gut bacteria balance. This research suggests that natural compounds from citrus peels might help protect our bodies from the health risks of microplastics that we encounter in our food and environment.
Nanoplastic-Induced Liver Damage Was Alleviated by Maltol via Enhancing Autophagic Flow: An In Vivo and In Vitro Study
Researchers found that nanoplastic exposure caused liver damage in mice through oxidative stress, cell death, and impaired cellular recycling processes. They then tested maltol, a compound derived from red ginseng, and found it significantly reduced the liver damage by restoring healthy autophagy and reducing oxidative stress. The study suggests that natural compounds like maltol could potentially help protect the liver from the harmful effects of nanoplastic accumulation.
Canidin-3-glucoside prevents nano-plastics induced toxicity via activating autophagy and promoting discharge
Researchers showed that cyanidin-3-glucoside (C3G), a natural anthocyanin, reduced polystyrene nanoplastic toxicity in Caco-2 cells and C. elegans by activating autophagy and promoting cellular discharge of internalized particles, suggesting a dietary protective mechanism.
Impact of Environmental Microplastic Exposure on Caco-2 Cells: Unraveling Proliferation, Apoptosis, and Autophagy Activation
Researchers exposed human intestinal cells to polyethylene and PET microplastics of different sizes and observed significant decreases in cell survival along with increased oxidative stress. The microplastics triggered both programmed cell death (apoptosis) and the cell's self-recycling process (autophagy), with effects varying by particle size. The study suggests that microplastic exposure may compromise the intestinal barrier through multiple pathways of cellular damage.
Nanoplastics induced health risk: Insights into intestinal barrier homeostasis and potential remediation strategy by dietary intervention
Researchers showed that environmentally aged nanoplastics disrupt intestinal barrier integrity by increasing permeability, triggering inflammation via AP-1 signaling, and inducing mitochondrial apoptosis, and that dietary quercetin counteracts these effects by activating the Nrf2 antioxidant pathway and suppressing p38/JNK phosphorylation.
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics
Researchers found that polystyrene nanoplastics accumulate in the cytoplasm of intestinal epithelial cells, impairing autophagic flux and triggering an autophagic stress response confirmed in both cell and animal models.
Effect of microplastics and nanoplastics in gastrointestinal tract on gut health: A systematic review.
This systematic review of 30 in vitro studies found that microplastics and nanoplastics cause size- and concentration-dependent damage to human gastrointestinal cells, including increased oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Smaller particles consistently showed greater cellular uptake and biological effects, though chronic low-dose exposure generally produced minimal impacts.
Quercetin intervention mitigates small intestinal damage and immunologic derangement induced by polystyrene nanoplastics: Insights from multi-omics analysis in mice
Researchers found that quercetin, a natural compound found in fruits and vegetables, protected mice from gut damage and immune system disruption caused by polystyrene nanoplastics. The nanoplastics damaged the small intestine and disrupted immune balance, but quercetin reversed much of this harm by restoring healthy gut bacteria and gene activity. This suggests that dietary compounds like quercetin might help counteract some negative health effects of nanoplastic exposure.
Rosmarinic acid alleviates intestinal inflammatory damage and inhibits endoplasmic reticulum stress and smooth muscle contraction abnormalities in intestinal tissues by regulating gut microbiota
This study found that rosmarinic acid, a natural plant compound, protected mice from intestinal inflammation by restoring healthy gut bacteria and reducing cell stress and damage. While not directly about microplastics, the research is relevant because microplastics are known to cause similar gut inflammation and disrupt the gut microbiome. Understanding how natural compounds can repair gut damage may help develop strategies to counteract the harmful effects of microplastic exposure on digestive health.
The role of human intestinal mucus in the prevention of microplastic uptake and cell damage
Researchers studied how the mucus lining of the human intestine acts as a barrier against microplastic particles of different sizes and surface coatings. The mucus layer significantly reduced microplastic uptake by cells and protected against toxicity and inflammation. This study suggests that a healthy intestinal mucus layer is an important natural defense against the harmful effects of swallowed microplastics.
Oxidative and Inflammatory Damage by Environmental Polyethylene Microplastics in Caco‐2 Cells Is Prevented by Polyphenol‐Rich Limoncella Apple Extract
Lab experiments on human gut cells (Caco-2) found that polyethylene microplastics increase oxidative stress and trigger cellular changes associated with disease progression, but that an extract from Limoncella apples rich in polyphenols could counteract these harmful effects. This raises the possibility that dietary antioxidants could offer a protective strategy against microplastic-induced damage in the human digestive system.
Narirutin ameliorates polystyrene microplastics induced nephrotoxicity by modulating oxidative stress, inflammation and Nrf2/Keap1 pathway
Researchers investigated whether narirutin, a natural compound found in citrus fruits, could protect kidneys from damage caused by polystyrene microplastics in rats. The study suggests that microplastic exposure triggered significant kidney stress through oxidation and inflammation, but narirutin helped reduce that damage by activating protective cellular pathways.
A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals
This review explored how plant-based compounds could be used to treat ulcerative colitis by targeting mitochondrial function. Researchers discussed how dysfunctional mitochondria generate excessive reactive oxygen species that drive intestinal inflammation. While focused on therapeutic approaches rather than microplastics directly, the study is relevant to understanding how environmental stressors that damage mitochondria may contribute to gut inflammation.
Quantifying the influence of micro and nanoplastics characteristics on cytotoxicity in caco-2 cells through machine learning modelling.
This systematic review uses machine learning to identify which characteristics of micro and nanoplastics are most toxic to intestinal cells. The researchers found that particle size, shape, and concentration all play important roles in how much damage these plastics cause to gut lining cells, helping us understand how ingested microplastics might affect digestive health.
Impact of polyethylene nanoplastics on human intestinal cells
Researchers tested the effects of polyethylene nanoplastics on human intestinal cell lines and found that particles prepared with cationic chemical initiators caused significant cell damage, oxidative stress, and DNA damage over time. Cells that produce a protective mucus layer were largely unaffected, suggesting that mucus may serve as a natural defense. The findings indicate that the surface chemistry of nanoplastics, not just their size, plays a critical role in determining their toxicity to gut tissue.
Quantifying the influence of micro and nanoplastics characteristics on cytotoxicity in caco-2 cells through machine learning modelling.
This systematic review uses machine learning to determine which properties of micro and nanoplastics drive toxicity in human intestinal cell models. The findings reveal that smaller particles and higher concentrations cause more cell damage, which is important for understanding how the microplastics we swallow in food and water might harm our gut lining.
Protective effect of curcumin against microplastic and nanoplastics toxicity
Researchers reviewed studies examining whether curcumin, the active compound in turmeric, can protect against the toxic effects of micro- and nanoplastics in the body. Evidence indicates that curcumin helped reduce oxidative stress, inflammation, and organ damage caused by plastic particle exposure across multiple organ systems in animal studies. The review suggests that natural antioxidant compounds like curcumin may hold promise for mitigating some of the harmful effects of plastic pollution on health.
Assessment of the cytotoxicity micro- and nano-plastic on human intestinal Caco-2 cells and the protective effects of catechin.
Researchers used a human intestinal cell line (Caco-2) to test cytotoxicity of polystyrene micro- and nano-plastics, finding dose-dependent cell damage and disruption of intestinal barrier function. The study supports growing concerns that ingested microplastics could contribute to gut inflammation and compromise the protective lining of the human intestine.
Sakuranetin counteracts polyethylene microplastics induced nephrotoxic effects via modulation of Nrf2/Keap1 pathway
Researchers found that polyethylene microplastics caused kidney damage in rats by increasing oxidative stress and disrupting a key protective cellular pathway. However, when the natural plant compound sakuranetin was administered alongside the microplastics, it significantly reduced the kidney damage by restoring antioxidant defenses. The study suggests that certain natural compounds may help counteract some of the harmful effects of microplastic exposure on organ health.
Estudio de los efectos toxicológicos de los nanoplásticos en células de colon
This Spanish-language study investigated the toxic effects of nanoplastics (plastic particles smaller than 1 micrometre) on human colon cells, examining how these tiny particles may cross biological barriers and enter the body through contaminated food and drink. The research contributes to understanding the potential health risks of nanoplastics in the gastrointestinal tract, an important pathway for human exposure.