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61,005 resultsShowing papers similar to Life cycle exposure to differentially charged polystyrene nanoplastics leads to gender-specific particle accumulation and neurotoxicity in zebrafish (Danio rerio)
ClearCharge-specific adverse effects of polystyrene nanoplastics on zebrafish (Danio rerio) development and behavior
Researchers exposed developing zebrafish to positively and negatively charged nanoplastics and found that the positively charged particles were significantly more toxic, accumulating in the brain and gut and causing developmental delays and brain cell death. The two types of nanoplastics affected different neurotransmitter pathways and interacted with different brain receptors, explaining their distinct behavioral effects. The study demonstrates that the surface charge of nanoplastics plays a critical role in determining their toxicity to developing organisms.
Zebrafish (Danio rerio) Reproduction Is Affected by Life-Cycle Exposure to Differently Charged Polystyrene Nanoplastics with Sex-Specific Responses
Zebrafish were exposed throughout a full life cycle (120 days) to uncharged, positively charged, and negatively charged polystyrene nanoplastics at 10 micrograms per liter and assessed for reproductive effects. All three nanoplastic types disrupted sex hormone levels and reproductive gene expression, with effects differing by surface charge and biological sex.
Effect of functional groups of polystyrene nanoplastics on the neurodevelopmental toxicity of acrylamide in the early life stage of zebrafish
This zebrafish study found that nanoplastics with different surface coatings altered the neurodevelopmental toxicity of acrylamide, a common food contaminant formed during cooking. Positively charged nanoplastics worsened brain development problems by increasing acrylamide absorption, while negatively charged ones had a partially protective effect. The findings show that the surface chemistry of nanoplastics matters greatly for how they interact with other environmental contaminants to affect brain development.
Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
Researchers exposed zebrafish to environmentally realistic levels of polystyrene nanoplastics and found they caused both brain and reproductive damage. The nanoplastics disrupted neurotransmitter signaling and impaired the hormonal pathway connecting the brain to reproductive organs, with different effects in males and females. These findings suggest that even low-level nanoplastic exposure could affect both brain function and fertility in aquatic life that humans may consume.
Oppositely charged proteins lead to different effects on the bioaccumulation kinetics of polystyrene nanoplastics in zebrafish (Danio rerio)
Researchers studied how positively and negatively charged proteins in water affect the bioaccumulation of polystyrene nanoplastics in zebrafish. The study found that different protein types altered nanoplastic uptake kinetics in distinct ways, suggesting that the natural protein environment in water bodies plays an important role in determining how nanoplastics accumulate in aquatic organisms.
Polystyrene nanoplastics alter intestinal toxicity of 2,4-DTBP in a sex-dependent manner in zebrafish (Danio rerio)
Researchers exposed zebrafish to polystyrene nanoplastics combined with an industrial chemical called 2,4-DTBP and found that the toxic effects on the intestines differed between males and females. In males, the nanoplastics made the chemical's gut damage worse, while in females the combination actually reduced harm compared to the chemical alone. The study highlights that sex-specific biological differences can significantly change how organisms respond to combined plastic and chemical pollution.
Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio)
When zebrafish were exposed to both nanoplastics and triclosan (an antimicrobial chemical common in personal care products), the effects on reproduction differed between sexes. In males, nanoplastics increased triclosan levels in the testes and worsened sperm production problems, while in females, nanoplastics actually reduced triclosan in the ovaries and lessened some reproductive harm -- showing that nanoplastics can alter how the body absorbs and responds to other environmental chemicals.
Sex-specific reproductive toxicity of polystyrene nanoplastics and DEHP in adult zebrafish (Danio rerio)
Researchers studied how polystyrene nanoplastics and the plasticizer DEHP affect reproduction in male and female zebrafish when exposure occurs individually or together. They found that combined exposure caused gonadal tissue damage and oxidative stress in both sexes, but with strikingly different hormonal responses between males and females. The study suggests that nanoplastics and plastic additives disrupt reproductive endocrine function in sex-specific ways through the hormonal signaling axis.
Size-dependent and tissue specific accumulation of polystyrene microplastics and nanoplastics in zebrafish
Researchers tracked size-dependent accumulation of polystyrene micro- and nanoplastics in multiple zebrafish tissues, finding that smaller particles distributed more broadly throughout the body compared to larger ones. Nanoplastics showed greater systemic distribution including into brain and reproductive tissues, raising concerns about size-dependent health risks.
Nanoplastics transport in zebrafish brain: Molecular and phenotypic behavioral impacts
This study tracked how nanoplastics of two sizes (50 nm and 200 nm) accumulate in and clear from zebrafish brains. Smaller nanoplastics built up more and lasted longer in the brain, causing greater damage to neurons and more behavioral changes like reduced activity and impaired learning. The findings suggest that the tiniest plastic particles may pose the most risk to brain health because they are harder for the body to remove.
Polystyrene nanoplastics induced size-dependent developmental and neurobehavioral toxicities in embryonic and juvenile zebrafish
Researchers exposed zebrafish embryos and juveniles to polystyrene nanoplastics of three different sizes and found that all sizes crossed into the brain, eyes, and other organs. Smaller particles tended to cause different types of damage than larger ones, including changes in brain development and behavior. This size-dependent toxicity is relevant to human health because we are exposed to a wide range of nanoplastic sizes through food and water.
Neurotoxicity of polystyrene nanoplastics with different particle sizes at environment-related concentrations on early zebrafish embryos
Researchers exposed zebrafish embryos to polystyrene nanoplastics of different sizes at concentrations found in the environment and observed significant brain damage. The nanoplastics caused loss of neurons, shortened nerve fibers, and disrupted brain signaling systems that control behavior. Smaller nanoplastics caused the most severe damage because they could pass through protective barriers more easily, suggesting that the tiniest plastic particles pose the greatest risk to brain development.
Swim in Plastics:Clean Nanoplastics Cause MinimalMortality but Alter Neurobehavioral and Molecular Rhythms in Fish
Researchers exposed zebrafish embryos and larvae to three types of polystyrene nanoplastics with different surface charges (plain, amino-modified, carboxyl-modified) and tracked biodistribution and developmental effects. Up to 10 ppm exposure caused minimal mortality but disrupted swim bladder inflation and affected neurological pathways including circadian rhythm genes, with surface charge determining tissue distribution.
Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure
Researchers exposed adult zebrafish to polystyrene nanoplastics and found that the particles accumulated in the brain, liver, intestine, and gonads, causing significant behavioral and physiological changes. The fish showed disrupted energy metabolism, oxidative stress, and altered locomotion, aggression, and predator avoidance behaviors. The findings raise concerns about the widespread health risks of nanoplastic exposure, as these particles are small enough to cross biological membranes.
Polystyrene microplastics and nanoplastics induce neurotoxicity in zebrafish via oxidative stress and neurotransmitter disruption
Researchers exposed zebrafish embryos to polystyrene micro- and nanoplastics and found that both particle sizes caused neurodevelopmental toxicity, with nanoplastics being more potent. The plastic particles induced oxidative stress in the brain and disrupted neurotransmitter levels critical for normal neural development. The study suggests that microplastic and nanoplastic contamination in aquatic environments may pose significant risks to the neurological development of fish.
Comparing the effects and mechanisms of exposure to polystyrene nanoplastics with different functional groups on the male reproductive system
Scientists exposed male mice to polystyrene nanoparticles with different surface charges (unmodified, negatively charged, and positively charged) and found all three types damaged reproductive health by reducing sperm count, increasing sperm defects, and disrupting testicular tissue. The positively charged (amino-modified) nanoparticles were the most toxic, causing the greatest reproductive damage. This is important because as plastics age in the environment, they develop different surface charges that may make them more harmful to reproductive health than pristine plastic particles.
Induction of Male Reproductive Toxicity in Mice by Differentially Charged Polystyrene Microplastics
This study exposed male mice to polystyrene microplastics carrying different surface charges (positive, negative, or neutral) and found that all types caused reproductive toxicity, including damage to sperm quality and testicular tissue. Surface charge influenced the severity and mechanism of harm, with positively charged particles showing the strongest effects, suggesting that the chemical surface properties of microplastics — not just particle size — determine their toxicity. These findings are concerning given widespread human exposure to microplastics via food, water, and air, and the ongoing global decline in male fertility.
Charge-dependent negative effects of polystyrene nanoplastics on Oryzias melastigma under ocean acidification conditions
This study tested the combined effects of differentially charged polystyrene nanoplastics and ocean acidification on the marine fish Oryzias melastigma, finding that surface charge significantly influenced both independent and interactive toxicity. Negatively charged particles were generally more harmful, with effects exacerbated under acidified conditions.
Adverse adult-onset and multigenerational effects in zebrafish (Danio rerio) developmentally exposed to polystyrene nanoplastics
Researchers raised zebrafish exposed to nanoplastics during early development through to adulthood and found lasting reproductive impairment, heritable hyperactivity in offspring, and molecular changes in male reproductive and brain tissue linked to neurodegenerative disease pathways and endocrine disruption, demonstrating that brief developmental nanoplastic exposure can cause multigenerational harm.
From particle size to brain function: a zebrafish-based review of micro/nanoplastic-induced neurobehavioral toxicity and mechanistic pathways
This review uses zebrafish as a model to examine how micro- and nanoplastics cause neurobehavioral toxicity, linking particle size to brain function disruption. Researchers summarize evidence that these plastic particles impair fish behavior and cause molecular-level damage in the nervous system. The findings highlight the growing concern that micro- and nanoplastics are emerging neurotoxicants in aquatic environments.
Swim in Plastics: Clean Nanoplastics Cause Minimal Mortality but Alter Neurobehavioral and Molecular Rhythms in Fish
This zebrafish study found that even clean nanoplastics with no added chemicals caused changes in behavior and disrupted the body's internal clock at the molecular level, despite not causing death. Different surface charges on the nanoplastics triggered different effects, with positively charged particles being the most disruptive. The findings suggest that nanoplastics can affect brain function and biological rhythms at exposure levels that might appear safe based on survival alone.
Surface-charge-dependent ovarian toxicity of polystyrene microplastics: Insights into accumulation, mitochondrial damage, and macrophage polarization
Researchers investigated how polystyrene microplastics with different surface charges accumulate in and damage rat ovaries after oral exposure. Positively charged amino-modified microplastics accumulated most in ovarian tissue and caused the most severe effects, including hormonal disruption, oxidative stress, and mitochondrial damage. The study suggests that surface charge is a key factor determining how microplastics affect reproductive organs.
Differentially Charged Nanoplastics Induce Distinct Effects on the Growth and Gut of Benthic Insects (Chironomus kiinensis) via Charge-Specific Accumulation and Perturbation of the Gut Microbiota
Researchers exposed aquatic insect larvae to positively and negatively charged nanoplastics and found that the surface charge significantly affected how toxic the particles were. Positively charged nanoplastics caused more severe gut damage, greater accumulation in tissues, and bigger disruptions to gut bacteria. This matters because nanoplastics in the real environment carry various charges, and the findings suggest that charge is an important factor in determining health risks.
Mechanisms Underlying the Size-Dependent Neurotoxicity of Polystyrene Nanoplastics in Zebrafish
Scientists discovered that smaller nanoplastics cause more severe brain and nerve damage in zebrafish than larger ones, and identified the molecular pathways behind this size-dependent toxicity. The smaller particles more easily crossed biological barriers and triggered greater oxidative stress and inflammation in the nervous system, which is important for understanding potential neurological risks of nanoplastic exposure.