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Zebrafish (<i>Danio rerio</i>) Reproduction Is Affected by Life-Cycle Exposure to Differently Charged Polystyrene Nanoplastics with Sex-Specific Responses

ACS ES&T Water 2022 17 citations ? Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count. Score: 45 ? 0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.

Xiaoli Zhao, Xiaoli Zhao, Miaomiao Teng, Miaomiao Teng, Yunxia Li, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Xiaoli Zhao, Xiaoli Zhao, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Xiaoli Zhao, Miaomiao Teng, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Yunxia Li, Yunxia Li, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Miaomiao Teng, Lingfeng Zhou, Lingfeng Zhou, Fengchang Wu Xiaoli Zhao, Miaomiao Teng, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Lihui Zhao, Fengchang Wu Xiaoli Zhao, Lihui Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Fengchang Wu Xiaoli Zhao, Fengchang Wu Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Xiaoli Zhao, Fengchang Wu Fengchang Wu Fengchang Wu Miaomiao Teng, Di Shi, Miaomiao Teng, Yunxia Li, Fengchang Wu Miaomiao Teng, Miaomiao Teng, Xiaoli Zhao, John P. Giesy, Jiaqi Sun, Miaomiao Teng, Lihui Zhao, Lihui Zhao, Fengchang Wu Fengchang Wu Xiaoli Zhao, Xiaoli Zhao, Lihui Zhao, Lihui Zhao, John P. Giesy, John P. Giesy, Lihui Zhao, Lihui Zhao, Fengchang Wu Jiaqi Sun, John P. Giesy, Fengchang Wu Fengchang Wu John P. Giesy, Xiaoli Zhao, John P. Giesy, Xiaoli Zhao, Fengchang Wu Xiaoli Zhao, Fengchang Wu Fengchang Wu John P. Giesy, Fengchang Wu John P. Giesy, Xiaoli Zhao, Wentian Zhao, Lingfeng Zhou, Jiaqi Sun, Xiaoli Zhao, Fengchang Wu Fengchang Wu Miaomiao Teng, John P. Giesy, Xiaoli Zhao, John P. Giesy, Yunxia Li, John P. Giesy, Lingfeng Zhou, Xiaoli Zhao, Xiaoli Zhao, Lingfeng Zhou, Di Shi, Di Shi, Wentian Zhao, Wentian Zhao, Miaomiao Teng, Fengchang Wu Fengchang Wu Miaomiao Teng, Miaomiao Teng, John P. Giesy, Fengchang Wu Lingfeng Zhou, Miaomiao Teng, Xia Wang, Miaomiao Teng, Lingfeng Zhou, Xiaoli Zhao, Xiaoli Zhao, Xia Wang, Lingfeng Zhou, Fengchang Wu Xia Wang, Fengchang Wu Fengchang Wu Fengchang Wu John P. Giesy, John P. Giesy, John P. Giesy, Fengchang Wu Fengchang Wu Xiaoli Zhao, Fengchang Wu Fengchang Wu Fengchang Wu Xiaoli Zhao, Fengchang Wu Fengchang Wu

Summary

Zebrafish were exposed throughout a full life cycle (120 days) to uncharged, positively charged, and negatively charged polystyrene nanoplastics at 10 micrograms per liter and assessed for reproductive effects. All three nanoplastic types disrupted sex hormone levels and reproductive gene expression, with effects differing by surface charge and biological sex.

Polymers

Body Systems

Reproductive

Models

Zebrafish

While nanoplastics (NPs) are distributed ubiquitously in the environment, limited information is available for assessing the effects of different charges on their surfaces on the reproduction of aquatic vertebrates, especially at environmentally realistic concentrations. In this study, starting with embryos, zebrafish (Danio rerio) were exposed to 10 μg/L polystyrene (PS, no charge), PS–NH2 (positive charge), or PS-COOH (negative charge) nanoplastics during a full life cycle (120 days) and their effects on reproductive performances, sex hormones, and expression of genes associated with steroidogenic pathways were investigated. Alterations of vitellogenin (VTG) and DNA methylation, as well as the development of offspring (F1) without subsequent chemical exposure, were further examined. The fecundity of females was significantly decreased by exposure to 10 μg/L PS or PS-COOH. In females, testosterone content was significantly higher along with down-regulation of cyp19a1a upon treatment with differently charged PS. The significant decrease of 11-ketotestosterone (11-KT) in male plasma reduced the proportion of mature spermatocytes in the testis. Parental exposure to differently charged PS resulted in the abnormal development of F1 in clean water. Comprehensive analysis showed that life-cycle exposure of zebrafish to differently charged PS affects reproductive performance in a sex-specific manner and impairs the development of F1. This study provides a theoretical foundation for risk management measures of differently charged nanoplastics.

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