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61,005 resultsShowing papers similar to Cinnamomum burmanii Leaf Extract Potential on Hematological Assessment of Rats Exposed to Polystyrene Nanoplastics
ClearProtection of Exogenous Antioxidant of Cinnamomum burmanii as a Hepatoprotective on the Toxicological Responses of Nanoplastics in Rats (Rattus norvegicus L.)
Researchers tested whether Cinnamomum burmanni leaf extract (CLE) protects rat liver function from polystyrene nanoplastic toxicity, administering NPs orally for 14 days with or without 100–400 mg/kg CLE for 28 days. NPs caused oxidative stress and liver damage, while CLE at 200–400 mg/kg significantly reduced hepatotoxicity markers and restored antioxidant enzyme activity, suggesting hepatoprotective potential against nanoplastic-induced toxicity.
Potential of Cinnamomum burmanni Leaf Extract as an Exogenous Antioxidant and Spermatoprotective for Rattus norvegicus L. Exposed to Polystyrene Nanoplastics
Researchers tested whether Cinnamomum burmanni leaf extract could protect male rat reproductive function against polystyrene nanoplastic (NP) toxicity by acting as an exogenous antioxidant. NPs increased oxidative stress and impaired sperm quality and spermatogenic cell counts, while C. burmanni extract at 200–400 mg/kg restored SOD and CAT activity, improved sperm parameters, and protected testicular morphology.
Investigating the protective effects of epigallocatechin-gallate against polystyrene microplastics-induced biochemical and hematological alterations in rats
This study investigated whether epigallocatechin-gallate (EGCG) -- a green tea antioxidant -- could protect rats from biochemical and hematological damage caused by polystyrene microplastic ingestion. EGCG supplementation partially mitigated oxidative stress and inflammatory markers elevated by polystyrene microplastic exposure, suggesting a potential dietary protective strategy.
Antioxidant Potential of Mangifera foetida Bark, Mangifera foetida Leaves, and Cinnamomum burmanii Leaves Extract in Mitigating Nanoplastic‐Induced Toxicity and Disruption of Glycolipid Metabolism
Researchers tested whether plant extracts from Mangifera foetida and Cinnamomum burmanii could reduce nanoplastic-induced metabolic disruption in rats, finding that the antioxidant compounds in these extracts partially mitigated nanoplastic-associated disruption of glycolipid metabolism.
Metabolomic characteristics in human CD34+ hematopoietic stem/progenitor cells exposed to polystyrene nanoplastics
Researchers examined metabolomic changes in human CD34+ hematopoietic stem/progenitor cells exposed to polystyrene nanoplastics, finding significant metabolic disruptions that suggest nanoplastics may impair human blood cell development.
Potential of Macang (Mangifera foetida) Bark Extract on Antioxidant Levels and Pro-Apoptotic Proteins in Rats (Rattus norvegicus) Exposed to Polystyrene Nanoplastics
Researchers assessed whether Mangifera foetida (macang) bark extract could protect male rats against reproductive and immune damage caused by polystyrene nanoplastic exposure, finding that the extract's antioxidant compounds partially restored superoxide dismutase activity and reduced apoptosis markers at 500 mg/kg doses.
Therapeutic indication of caffeine and vitamin c on haematological profile in heparin, phenylhydrazine and aspirin induced haematological derangements in male Wistar rats
Not relevant to microplastics — this is a pharmacological study testing whether caffeine and vitamin C can correct blood disorders (anemia, low white blood cells, low platelets) induced by heparin, phenylhydrazine, and aspirin in laboratory rats.
Nanoplastic-induced vascular endothelial injury and coagulation dysfunction in mice
Researchers exposed mice to polystyrene nanoplastics with different surface modifications and found that the particles caused structural damage to vascular endothelial cells and triggered inflammatory responses. The nanoplastics also disrupted blood coagulation function in the mice. The study suggests that nanoplastic exposure may pose risks to cardiovascular health due to the particles' ability to travel through the bloodstream and damage blood vessel linings.
Effect of Polystyrene Nanoplastic on Colon, Liver, and Spleen Histopathology of Rats (Rattus norvegicus L.)
This study exposed rats to different concentrations of polystyrene nanoplastics and examined the effects on their colon, liver, and spleen. The results showed tissue damage including inflammation and cell death in all three organs, with higher concentrations causing more severe effects. These findings suggest that nanoplastics small enough to enter the body can cause organ-level damage, raising concerns about long-term human exposure.
Preliminary study on impacts of polystyrene microplastics on the hematological system and gene expression in bone marrow cells of mice
Researchers studied the effects of polystyrene microplastics on the blood system and bone marrow gene expression in mice. They found that higher doses significantly decreased white blood cell counts and altered gene expression patterns in bone marrow cells, suggesting that microplastic exposure may affect the hematological system in mammals through changes in immune-related gene regulation.
Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats
Researchers investigated whether polystyrene nanoplastics promote blood coagulation activity in human red blood cells. The study found that amine-modified 100 nm nanoplastics were taken up by red blood cells, caused morphological changes, induced phosphatidylserine externalization, and generated microvesicles, suggesting that certain nanoplastics may promote procoagulant activity and potentially contribute to thrombus formation.
Evaluation of In Vitro Genotoxicity of Polystyrene Nanoparticles in Human Peripheral Blood Mononuclear Cells
Researchers evaluated the genotoxic potential of polystyrene nanoparticles in human peripheral blood mononuclear cells, finding evidence of DNA damage that raises concerns about the health effects of nanoplastic exposure in humans.
Toxicological Effects and Potential Therapeutics of Chronic Exposure to Polyurethane Nanoplastics in Caenorhabditis elegans
Researchers exposed the model organism C. elegans to polyurethane nanoplastics at environmentally relevant concentrations and found dose-dependent toxic effects including reduced reproduction, impaired movement, and shortened lifespan. The study also found that cinnamon essential oil showed potential as a therapeutic agent, enhancing antioxidant defenses and partially mitigating the harmful effects of nanoplastic exposure at lower concentrations.
Nanoplastics-induced oxidative stress, antioxidant defense, and physiological response in exposed Wistar albino rats
Researchers orally exposed Wistar rats to polystyrene nanoplastics at multiple doses for five weeks and observed dose-dependent increases in oxidative stress. The study found significant alterations in liver and kidney function markers, disrupted energy metabolism, and changes in antioxidant enzyme activity, suggesting that nanoplastic exposure may affect multiple organ systems in mammals.
Sinensetin mitigates polystyrene nanoplastics induced hepatotoxicity in albino rats: A biochemical and histopathological study
Exposure to polystyrene nanoplastics caused significant liver damage in rats, including oxidative stress, inflammation, and cell death, along with elevated liver enzymes that are markers of liver injury in clinical settings. Treatment with sinensetin — a natural plant flavonoid — substantially reversed these effects, restoring antioxidant enzyme activity and reducing inflammatory markers. The findings establish a potential protective role for natural compounds against nanoplastic-induced organ toxicity and illuminate the mechanisms by which nanoplastics harm the liver.
Interaction of polystyrene nanoplastics with human fibrinogen
Researchers found that polystyrene nanoplastics with different surface modifications disrupted the structure of human fibrinogen, a key blood clotting protein, in a dose-dependent manner. The study suggests that nanoplastics entering the bloodstream could interfere with protein function, raising concerns about the potential biological consequences of nanoplastic exposure in humans.
Tea Polyphenol EGCG Increases Nanoplastics Release from Plastic Cups but Mitigates Potential Detrimental Effects
Researchers found that the tea polyphenol EGCG increases nanoplastic release from polystyrene cups during heating, but EGCG simultaneously mitigates the potential detrimental cellular effects of those nanoplastics through its antioxidant properties.
Polystyrene micro-/nanoplastics induced hematopoietic damages via the crosstalk of gut microbiota, metabolites, and cytokines
Researchers exposed mice to polystyrene micro- and nanoplastics and found that the particles caused damage to the blood-forming system through disruption of gut bacteria, metabolic changes, and inflammatory signaling. Smaller nanoplastics caused more severe effects than larger microplastics, altering gut microbial communities and triggering systemic inflammation. The study reveals a previously unknown pathway by which ingested plastic particles may harm the body's ability to produce healthy blood cells.
Effect of Polystyrene Microplastics Exposure on Blood Parameters in Mice
Researchers exposed mice to polystyrene microplastics in drinking water over four weeks and found increased white blood cell counts, elevated liver enzymes indicating hepatic injury, and altered kidney function markers. The study suggests that subchronic oral microplastic exposure induces inflammatory responses and disrupts liver and kidney function, with no significant recovery observed after a two-week withdrawal period.
Genotoxic and immunomodulatory effects in human white blood cells after ex vivo exposure to polystyrene nanoplastics
Human white blood cells were exposed ex vivo to polystyrene nanoplastics and showed DNA strand breaks, chromosomal damage, and changes in immune cell activation markers, suggesting that nanoplastics at environmentally relevant concentrations could cause genotoxic and immunomodulatory effects in people.
Hazard assessment of different-sized polystyrene nanoplastics in hematopoietic human cell lines
Researchers tested how different sizes of polystyrene nanoplastics (50, 200, and 500 nm) affect human blood cell lines. While none of the sizes caused direct cell death, all three were taken up by cells and disrupted mitochondrial function in immune-related cell types. The study suggests that even without killing cells outright, nanoplastics may interfere with important cellular energy processes, with effects varying by particle size and cell type.
Evaluation of Hematotoxicity in Female Wistar Rats Following Sub-Acute Inhalation Exposure to Polyethylene Microplastic
Female Wistar rats were exposed to polyethylene microplastic aerosols at 15 mg per cubic meter for 4 hours daily over 28 days, and blood analysis revealed alterations in erythrocyte, leukocyte, and platelet counts. The findings suggest that sub-acute inhalation of polyethylene microplastics can cause hematotoxic effects.
Screening for polystyrene nanoparticle toxicity on kidneys of adult male albino rats using histopathological, biochemical, and molecular examination results
Researchers found that oral exposure to polystyrene nanoparticles caused significant kidney damage in rats, including oxidative stress, impaired renal function, and tissue alterations that worsened with increasing dose, demonstrating their nephrotoxic potential.
Hematological consequences of polyethylene microplastics toxicity in male rats: Oxidative stress, genetic, and epigenetic links
Researchers gave male rats different doses of polyethylene microplastics orally for 35 days and found significant damage to blood cells and the blood-forming system. Higher doses caused oxidative stress, DNA damage, and changes in gene expression patterns related to blood cell production. The study suggests that chronic microplastic ingestion could harm the blood system through both genetic and epigenetic pathways.