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Genotoxic and immunomodulatory effects in human white blood cells after ex vivo exposure to polystyrene nanoplastics
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Human white blood cells were exposed ex vivo to polystyrene nanoplastics and showed DNA strand breaks, chromosomal damage, and changes in immune cell activation markers, suggesting that nanoplastics at environmentally relevant concentrations could cause genotoxic and immunomodulatory effects in people.
Accumulation of plastic and its derivatives, micro- and nanoplastics (MNPLs), is a substantial environmental and ecological problem that could potentially become a serious health concern to humans.
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Evaluation of In Vitro Genotoxicity of Polystyrene Nanoparticles in Human Peripheral Blood Mononuclear Cells
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Researchers evaluated the genotoxic potential of polystyrene nanoparticles in human peripheral blood mononuclear cells, finding evidence of DNA damage that raises concerns about the health effects of nanoplastic exposure in humans.
Genotoxic and cytotoxic effects of polystyrene nanoplastics on human lymphocytes: A comprehensive analysis
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Researchers tested the effects of 50-nanometer polystyrene nanoplastics on human white blood cells in the laboratory. They found that even at low concentrations, the nanoplastics caused DNA damage, reduced cell viability, and triggered oxidative stress. The study provides evidence that nanoplastic particles small enough to enter the bloodstream could pose risks to human immune cell health.
The Biological Effects of Polystyrene Nanoplastics on Human Peripheral Blood Lymphocytes
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Researchers assessed the cytotoxic and genotoxic effects of polystyrene nanoplastics on human peripheral blood lymphocytes using chromosomal aberration and micronucleus assays. They found dose-dependent increases in cell damage, chromosomal abnormalities, and hemolytic activity at the tested concentrations. The study provides evidence that nanoplastic particles can cause genetic damage to human immune cells under laboratory conditions.
Biological effects, including oxidative stress and genotoxic damage, of polystyrene nanoparticles in different human hematopoietic cell lines
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Researchers exposed three human immune cell lines (B-lymphocytes, lymphoblasts, and monocytes) to 50 nm polystyrene nanoparticles and found cell-type-specific responses — monocytes internalized the most particles but showed no harm, while B-lymphocytes and lymphoblasts displayed oxidative stress and DNA damage despite lower uptake.
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