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61,005 resultsShowing papers similar to The Effect of Modern Lifestyle on Cardiovascular Health
ClearThe Effect of Modern Lifestyle on Cardiovascular Health
Researchers investigated how PET microplastics affect vascular endothelial function and tested whether Sirtuin 1 (SIRT1) could provide protection against PET-induced damage in human umbilical vein endothelial cells. PET exposure impaired endothelial function and increased inflammation, while SIRT1 activation partially restored vascular health markers.
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Researchers investigated how polyethylene and PVC microplastics affect vascular endothelial cells and identified underlying molecular mechanisms. The study found that microplastics triggered inflammatory responses and upregulated PCSK9 in endothelial cells, disrupting their function and redox balance. Inhibiting PCSK9 through a SIRT6-dependent pathway reduced the microplastic-induced damage, pointing to a potential therapeutic approach for vascular effects of microplastic exposure.
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Researchers investigated how polyethylene and PVC microplastics affect vascular endothelial cells and identified underlying molecular mechanisms. The study found that microplastics upregulated inflammatory mediators and a protein called PCSK9 in endothelial cells, disrupting their normal function and redox balance. Inhibiting PCSK9 through a SIRT6-dependent pathway ameliorated the microplastic-induced endothelial damage, suggesting a potential therapeutic target for addressing vascular effects of microplastic exposure.
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Researchers investigated how inhibiting PCSK9—a protein involved in cholesterol metabolism and cardiovascular risk—affects microplastic-induced oxidative damage in vascular endothelial cells. PCSK9 inhibition reduced microplastic-driven endothelial redox imbalance through SIRT6 modulation, suggesting a potential pharmacological strategy to protect the cardiovascular system from microplastic-associated vascular stress.
PET-microplastics trigger endothelial glycocalyx loss via ER stress and ROS unleashing IL-1β-driven SMC switching and early aortic structural impairment
Scientists found that tiny plastic particles from bottles and food packaging can damage blood vessels when consumed regularly. In lab rats, these microplastics caused harmful changes to the cells lining arteries, which could lead to heart disease over time. This research suggests that plastic pollution may pose a direct threat to our cardiovascular health, though more studies are needed to confirm the effects in humans.
PET-Microplastics Trigger Endothelial Glycocalyx Loss via ER Stress and ROS Unleashing IL-1β-Driven SMC Switching and Early Aortic Structural Impairment
Researchers found that chronic oral exposure of rats to PET microplastics caused endothelial glycocalyx damage and aortic structural injury, with endoplasmic reticulum stress and reactive oxygen species triggering IL-1β-driven smooth muscle cell switching as the underlying mechanism.
From Environment to Endothelium: The Role of Microplastics in Vascular Aging
This review examines how microplastics may contribute to vascular aging and cardiovascular problems. Evidence indicates that once microplastics enter the body through ingestion, inhalation, or skin contact, they can reach blood vessels and trigger oxidative stress, inflammation, and damage to the cells lining blood vessel walls. The findings suggest that chronic microplastic exposure could be an underappreciated factor in the development of age-related cardiovascular issues.
Relationship between microplastics and cardiovascular risk factors
This review examines the emerging evidence linking microplastic exposure to cardiovascular risk factors, including endothelial dysfunction, oxidative stress, and inflammation, which are early indicators of heart disease. The authors conclude that microplastics represent a newly recognized environmental cardiovascular risk factor warranting further clinical research.
Microplastics. a New Risk Factor for Atherosclerotic Cardiovascular Disease
This paper reviews emerging evidence linking microplastic exposure to atherosclerotic cardiovascular disease, noting that MPs have been detected in arterial plaques and human tissues and may contribute to cardiovascular risk through inflammation, oxidative stress, and endothelial disruption.
Micro and Nano-plastic particles: What are they and do they effect cardiovascular health?
This review examines the cardiovascular health effects of micro- and nanoplastics, summarizing evidence that these particles have been detected in human tissues including arterial plaques and may promote endothelial dysfunction and inflammation. The authors call for further clinical and epidemiological research into cardiac risk.
PET-Microplastics Trigger Endothelial Glycocalyx Loss via ER Stress and ROS Unleashing IL-1β-Driven SMC Switching and Early Aortic Structural Impairment
Chronic oral exposure of rats to PET microplastics at 1–100 mg/L caused endothelial glycocalyx loss and structural damage to aortic elastic fibers, with MPs accumulating in vascular tissue. Mechanistically, PET-MPs triggered ER stress and reactive oxygen species production, driving an IL-1β-mediated switch in smooth muscle cell phenotype and early arterial injury.
Microplastics: A Modifiable Cardiac Risk Factor
This review examines the emerging evidence linking microplastic exposure to cardiovascular disease risk factors, including oxidative stress, inflammation, endothelial dysfunction, and thrombosis. The study highlights that micro- and nanoplastics have been identified in coronary artery plaque, suggesting that microplastic exposure may represent a modifiable but currently underrecognized cardiac risk factor.
Microplastics and Cardiovascular Disease: Should Clinicians Be Paying Attention?
This clinical review summarizes evidence for microplastics as a cardiovascular risk factor, noting that they have been detected in human cardiovascular tissues and that in vitro and animal studies link them to oxidative stress, endothelial dysfunction, and platelet disruption, while cautioning that human evidence remains associative.
Influence of Micro- and Nanoplastics on Mitochondrial Function in the Cardiovascular System: A Review of the Current Literature
This review examined the limited but growing research on how micro- and nanoplastics may affect mitochondrial function in the cardiovascular system. Researchers noted that these plastic particles can trigger oxidative stress and disrupt normal mitochondrial processes, which are critical for heart and blood vessel health. The study highlights the need for more comprehensive research given the rising levels of plastic particle contamination and the importance of mitochondrial health in preventing cardiovascular problems.
Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells
Lab tests showed that common microplastics from food packaging (polyethylene and polystyrene) can activate human blood vessel smooth muscle cells in ways linked to atherosclerosis and vascular calcification. Photo-degraded microplastics -- the weathered kind found in the real environment -- triggered even stronger inflammatory responses, suggesting that environmental plastic pollution could contribute to cardiovascular disease.
Emerging cardiovascular risks of micro- and nanoplastics: toxic effects and mechanistic pathways
Tiny plastic particles called micro- and nanoplastics are getting into our bodies through food, air, and skin contact, and researchers have found them building up in people's hearts and blood vessels. This review of existing studies shows these plastic bits may contribute to heart disease by causing inflammation and damaging cells in the cardiovascular system. While more research is needed, this suggests that plastic pollution isn't just an environmental problem—it could be directly harming our heart health.
Virgin and Aged Microplastics Induce Type-specific Inflammatory Responses on Vascular Cells
Both virgin and UV-aged polystyrene and polyethylene microplastics triggered inflammatory responses in human coronary artery smooth muscle cells in vitro, with different polymer types and aging states producing distinct patterns of cellular damage. The results suggest that microplastics ingested or inhaled by people may contribute to vascular inflammation and worsen cardiovascular disease — a significant human health concern.
Additional file 1 of PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
This is a duplicate supplementary file for the PCSK9-microplastic endothelial study (same as ID 2730) — not a standalone research article.
Microplastics induce mitochondrial dysfunction and accelerate cardiovascular pathogenesis
Researchers reviewed evidence that micro- and nanoplastics detected in human cardiovascular tissues may contribute to cardiovascular disease through mitochondrial dysfunction. The study found that these particles can impair mitochondrial integrity, induce oxidative stress, disrupt calcium signaling, and promote genomic instability, suggesting a mechanistic link between plastic particle exposure and cardiovascular pathology.
Additional file 1 of PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
This entry is supplementary material (raw data files) for a study on how blocking a cholesterol-related protein (PCSK9) can protect blood vessel cells from oxidative damage caused by microplastics — not a standalone research article.
Cardiotoxicity of Microplastics: An Emerging Cardiovascular Risk Factor
This review examines emerging evidence that microplastics may pose risks to cardiovascular health, summarizing findings from laboratory and animal studies. Researchers found that microplastic exposure has been linked to inflammation, oxidative stress, and disrupted heart function in experimental settings. Given that cardiovascular disease is already the leading cause of death globally, the study suggests that microplastics as a potential contributing factor warrant urgent further investigation.
Micro- and nanoplastics and PM2.5 in cardiovascular disease: Emerging mechanisms, impacts, and therapeutic insights
This review synthesizes evidence linking micro- and nanoplastic exposure alongside fine particulate matter (PM2.5) to cardiovascular health risks, including endothelial dysfunction, atherosclerosis, and heart injury. Researchers found that these pollutants share common harmful mechanisms such as oxidative stress, mitochondrial dysfunction, and inflammatory reprogramming, suggesting they may act as underrecognized environmental risk factors for heart and vascular conditions.
Environmental Toxins and Oxidative Stress: The Link to Cardiovascular Diseases.
This review examined how environmental toxins—including microplastics, heavy metals, air pollutants, and endocrine disruptors—contribute to cardiovascular disease through oxidative stress mechanisms. It argued that environmental toxin exposure accounts for a meaningful share of cardiovascular morbidity that traditional risk factor models fail to capture.
An Emerging Role of Micro- and Nanoplastics in Vascular Diseases
This review summarizes emerging research on how micro- and nanoplastics may contribute to vascular diseases, which are the leading cause of death worldwide. Studies suggest that these tiny plastic particles can damage blood vessel walls, promote inflammation, and worsen conditions like atherosclerosis. While more research is needed, the evidence points to microplastic exposure as a potential new risk factor for heart and blood vessel diseases.