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Additional file 1 of PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Summary
This is a duplicate supplementary file for the PCSK9-microplastic endothelial study (same as ID 2730) — not a standalone research article.
Supplementary material 1.
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Additional file 1 of PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
This entry is supplementary material (raw data files) for a study on how blocking a cholesterol-related protein (PCSK9) can protect blood vessel cells from oxidative damage caused by microplastics — not a standalone research article.
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Researchers investigated how polyethylene and PVC microplastics affect vascular endothelial cells and identified underlying molecular mechanisms. The study found that microplastics upregulated inflammatory mediators and a protein called PCSK9 in endothelial cells, disrupting their normal function and redox balance. Inhibiting PCSK9 through a SIRT6-dependent pathway ameliorated the microplastic-induced endothelial damage, suggesting a potential therapeutic target for addressing vascular effects of microplastic exposure.
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Researchers investigated how inhibiting PCSK9—a protein involved in cholesterol metabolism and cardiovascular risk—affects microplastic-induced oxidative damage in vascular endothelial cells. PCSK9 inhibition reduced microplastic-driven endothelial redox imbalance through SIRT6 modulation, suggesting a potential pharmacological strategy to protect the cardiovascular system from microplastic-associated vascular stress.
PCSK9 inhibition ameliorates microplastic-induced endothelial redox imbalance via SIRT6 modulation
Researchers investigated how polyethylene and PVC microplastics affect vascular endothelial cells and identified underlying molecular mechanisms. The study found that microplastics triggered inflammatory responses and upregulated PCSK9 in endothelial cells, disrupting their function and redox balance. Inhibiting PCSK9 through a SIRT6-dependent pathway reduced the microplastic-induced damage, pointing to a potential therapeutic approach for vascular effects of microplastic exposure.
The Effect of Modern Lifestyle on Cardiovascular Health
This study found that PET microplastics impaired endothelial cell function by disrupting the SIRT1-eNOS-ROS balance, and that SIRT1 activation (as occurs during exercise) partially protected endothelial cells from PET-induced damage — linking plastic exposure to cardiovascular disease risk mechanisms.