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61,005 resultsShowing papers similar to Nanoplastics Impair GnRH Neuron Migration and Neuroendocrine Function: Emerging Players in the Pathogenesis of Reproductive Disorders
ClearMicro- and Nano-plastics may affect the central regulation of reproduction: insights from in vitro and in vivo studies on GnRH neurons.
This review examined evidence that micro- and nanoplastics can interfere with the central regulation of reproduction by disrupting hormonal signaling in the brain and endocrine glands. Animal studies show that plastic particle exposure can alter reproductive hormone levels and fertility outcomes.
Micro- and Nano-plastics may affect the central regulation of reproduction: insights from in vitro and in vivo studies on GnRH neurons.
This review examined how micro- and nanoplastics may interfere with the central nervous system regulation of reproduction, compiling evidence from animal studies. The analysis suggests that plastic particle exposure could disrupt hormonal signaling pathways that control reproductive function.
From gonads to generations: Mechanistic insights into reproductive disruption by polystyrene nanoplastics and co-contaminants in fish
This review synthesizes current research on how polystyrene nanoplastics impair reproductive health in fish, including disruption of gonad structure, hormone levels, and gene regulation along the reproductive axis. Researchers found that nanoplastics can cause oxidative stress and inflammation in reproductive tissues and may even affect offspring development. The findings raise concerns about the long-term effects of nanoplastic pollution on fish populations and aquatic ecosystem health.
Nano and microplastics: unveiling their profound impact on endocrine health
This review summarizes existing research showing that micro- and nanoplastics can disrupt the endocrine (hormone) system, altering reproductive hormones, thyroid function, and gene expression in lab and animal studies. Exposure to these particles triggered inflammation markers and oxidative stress in hormone-producing organs, suggesting that widespread plastic pollution may be contributing to rising rates of hormonal and reproductive health problems.
Effects of polystyrene nanoplastics on the female reproductive system in mice: Implications for ovarian function and follicular development
Researchers exposed female mice to polystyrene nanoplastics orally for 29 days and examined the effects on their reproductive systems. They found that nanoplastic exposure disrupted estrous cycles, impaired follicle development, and altered hormone levels in a dose-dependent manner. The study suggests that nanoplastics, due to their extremely small size, may cross biological barriers and accumulate in reproductive tissues, raising concerns about potential effects on fertility.
Effects of polystyrene micro- and nanoplastics on androgen- and estrogen receptor activity and steroidogenesis in vitro
Researchers tested how polystyrene micro and nanoplastics of various sizes affect hormone receptor activity and steroid hormone production in human cells grown in the lab. Smaller nanoplastics (50-1000 nm) were taken up into cells and interfered with both estrogen and androgen receptor signaling, while also altering the production of key hormones. This study provides direct evidence that nanoplastics can disrupt the human endocrine system at the cellular level, which could have implications for reproductive health.
Oral exposure to polystyrene nanoplastics altered the hypothalamic–pituitary–testicular axis role in hormonal regulation, inducing reproductive toxicity in albino rats
This study found that oral exposure to polystyrene nanoplastics disrupted the hormone signaling pathway between the brain and testes in male rats, leading to reproductive damage. The nanoplastics interfered with the hormones that regulate sperm production and testicular function. These findings add to growing evidence that nanoplastic exposure through food and water could be a contributing factor to declining male fertility.
Understanding the impact of nanoplastics on reproductive health: Exposure pathways, mechanisms, and implications
This review summarizes existing research on how nanoplastics (tiny plastic particles smaller than one micrometer) affect reproductive health in animals and potentially humans. Studies show that nanoplastics can accumulate in reproductive organs including the placenta, and evidence from animal studies links exposure to hormone disruption, reduced fertility, and developmental problems. The authors highlight a significant knowledge gap about nanoplastic effects on human reproduction, despite growing evidence that these particles reach our reproductive systems.
The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge
Researchers administered polystyrene nanoplastics orally to male rats for five weeks and found significant reductions in testosterone, LH, and FSH levels, sperm DNA damage, altered testicular gene expression, and dose-dependent histological lesions, indicating that nanoplastic exposure disrupts the hormonal axis governing male reproductive function.
Micro- and Nanoplastics as Disruptors of the Endocrine System—A Review of the Threats and Consequences Associated with Plastic Exposure
This review summarizes how micro- and nanoplastics carry endocrine-disrupting chemicals that interfere with hormones controlling reproduction, thyroid function, metabolism, and brain development. The reproductive system is especially vulnerable, with studies showing that plastic particle exposure can cause oxidative stress, cell death, and infertility, raising serious concerns given how widespread these particles are in food and the environment.
The endocrine disrupting effects of nanoplastic exposure: A systematic review
This systematic review summarizes research on how nanoplastics, the smallest plastic particles, can disrupt the hormonal system. The evidence from lab studies suggests nanoplastics may interfere with thyroid function, reproductive hormones, and stress responses. These findings raise concerns because endocrine disruption can lead to fertility problems, metabolic issues, and developmental effects in humans.
Impact of nanoplastics on thyroid function: Unraveling cellular biokinetics, molecular mechanisms and human risk assessment
Researchers investigated the effects of polystyrene nanoplastics on thyroid-derived cell lines, finding rapid intracellular uptake, disruption of redox balance, and altered expression of thyroid hormone-related genes and proteins. The findings indicate that nanoplastics can directly disrupt thyroid cell function through oxidative stress and interference with hormone biosynthesis pathways.
Microplastics and endocrine disruption: Emerging risks for human fertility
This short communication reviewed emerging evidence that microplastics and nanoplastics disrupt endocrine function and reproductive health, highlighting effects on hormonal regulation, gametogenesis, and fertility outcomes. The authors called for more epidemiological studies to establish links between human microplastic exposure and fertility decline.
Polystyrene nanoplastics act as endocrine disruptors altering neurotransmitter levels and locomotor activity via estrogen receptor during early zebrafish development
Researchers showed that polystyrene nanoplastics act as endocrine disruptors in developing zebrafish by activating estrogen receptor pathways, causing reduced dopamine neuron area, increased brain cell death, and impaired movement — effects that were reversed when the estrogen receptor was blocked.
Impacts of Environmental Concentrations of Nanoplastics on Zebrafish Neurobehavior and Reproductive Toxicity
Researchers exposed zebrafish to environmentally realistic levels of polystyrene nanoplastics and found they caused both brain and reproductive damage. The nanoplastics disrupted neurotransmitter signaling and impaired the hormonal pathway connecting the brain to reproductive organs, with different effects in males and females. These findings suggest that even low-level nanoplastic exposure could affect both brain function and fertility in aquatic life that humans may consume.
The ovarian-related effects of polystyrene nanoplastics on human ovarian granulosa cells and female mice
This study tested the effects of polystyrene nanoplastics on both human ovarian cells in the lab and on female mice. The nanoplastics accumulated in ovarian tissue, caused cell death, disrupted hormone levels, and reduced egg quality and fertility in mice. These findings suggest that nanoplastic exposure could threaten female reproductive health by damaging the ovaries.
New insights into the reproductive hazards posed by polystyrene nanoplastics
Researchers used fruit flies as a model to study how polystyrene nanoplastics affect reproductive health. They found that nanoplastics accumulated in ovaries, testes, and even individual eggs and sperm cells, causing physical damage to reproductive organs and reducing fertility. The study suggests that nanoplastic contamination can directly interfere with reproduction by physically accumulating within reproductive tissues and gametes.
Effects of micro(nano)plastics on the reproductive system: A review
This review summarizes research on how micro and nanoplastics affect the reproductive system in both animal studies and cell experiments. Evidence indicates these particles can cross biological barriers, accumulate in reproductive organs, and disrupt hormones, egg development, and sperm quality. While human studies are still limited, the animal data suggests microplastic exposure may be a meaningful concern for reproductive health.
PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction.
This review assessed evidence for neurotoxic and reproductive effects of both biodegradable and conventional micro- and nanoplastics, finding that plastic particles and their chemical additives can cross the blood-brain barrier and disrupt hormone systems, with concerning implications for nervous system and reproductive health.
Nanoplastics impair in vitro swine granulosa cell functions
Polystyrene nanoplastics at the highest tested concentration (75 µg/mL) stimulated cell proliferation and steroid hormone secretion in swine granulosa cells while also increasing oxidative stress, suggesting potential endocrine disruption in female reproductive cells.
"Unseen Dangers: The Effects of Micro- and Nanoplastics on Human Reproductive Health - A Narrative Review"
This review examines the effects of micro- and nanoplastics on human reproductive health, covering evidence from in vitro, animal, and epidemiological studies showing that plastic particles can disrupt hormone signaling, sperm function, ovarian development, and placental integrity.
Short-term polystyrene nanoplastic exposure alters zebrafish male and female germline and reproductive outcomes, unveiling pollutant-impacted molecular pathways
A short 96-hour exposure to polystyrene nanoplastics harmed both male and female reproductive cells in zebrafish. In males, nanoplastics crossed the testicular barrier, entered reproductive cells directly, and caused abnormal sperm with reduced movement. In females, the exposure disrupted egg development, suggesting that even brief nanoplastic contact could impair fertility in aquatic species and raising questions about similar risks for human reproductive health.
Adverse effects of microplastics and nanoplastics on the reproductive system: A comprehensive review of fertility and potential harmful interactions
This review summarizes how microplastics and nanoplastics can harm both male and female reproductive systems by disrupting hormone signaling, damaging sperm and egg cells, and causing inflammation in reproductive tissues. Smaller nanoplastics are especially concerning because they can cross biological barriers more easily and reach the testes and ovaries. With global infertility rates rising, the authors highlight environmental plastic exposure as a factor that deserves more research attention.
A review of the impact of micro‐ and nanoplastics on female reproduction: What we know and gaps in knowledge
This review examines what is known about how micro- and nanoplastics affect female reproductive health. Animal studies show these particles accumulate in ovarian tissue, disrupt hormones, and cause oxidative stress, leading to hormonal imbalances and ovarian damage, though research in humans is still limited.