We can't find the internet
Attempting to reconnect
Something went wrong!
Hang in there while we get back on track
Polystyrene nanoplastics exacerbated the ecotoxicological and potential carcinogenic effects of tetracycline in juvenile grass carp (Ctenopharyngodon idella)
AI summary Read the abstract
Researchers found that polystyrene nanoplastics significantly worsened the toxic effects of the antibiotic tetracycline in juvenile grass carp. Combined exposure increased oxidative damage, upregulated genes associated with tissue remodeling and inflammation in the liver and intestine, and caused visible tissue lesions in the intestine and gills.
This study aims to evaluate the ecotoxicity effects of single tetracycline (TC) exposure and mixture exposure in presence of polystyrene nanoplastics (PS-NPs, 80 nm) on juvenile Ctenopharyngodon idella. We carried out single and combined exposure of TC (5000 μg/L) and PS-NPs (20, 200, 2000 μg/L) for 7 days. Compared to TC single exposure, co-exposure to PS-NPs and TC significantly changed the levels of antioxidant entities, including T-AOC, SOD, and CAT in the liver and intestine of C. idella, indicating that PS-NPs might enhance the oxidative damage caused by TC. Further, the co-exposure significantly upregulated the mRNA expression levels of MMP2, MMP9, and IL-8 in a concentration-dependent manner in the liver and intestine tissues of C. idella, compared to the control and TC single exposure groups. Moreover, the phylogenetic tree showed that MMP2 and MMP9 in C. idella are relatively conservative, and the mRNA expressions of MMP2 are significantly positively correlated with TGFβ1, IL8, and MMP9 in Liver hepatocellular carcinoma (LIHC) and Colon adenocarcinoma (COAD). The above genes in LIHC and COAD were significantly correlated with various immune cells. Further, histopathological analysis revealed tissue lesions in the intestine and gill of fish in all the exposed groups, compared to the control group. In short, the present study illustrated that the toxicological effects of organic pollutants such as TC could be influenced by the presence of NPs in the C. idella.
More Papers Like This
Concurrent impacts of polystyrene nanoplastic exposure and Aeromonas hydrophila infection on oxidative stress, immune response and intestinal microbiota of grass carp (Ctenopharyngodon idella)
AI summary Read the abstract
Researchers studied the combined effects of polystyrene nanoplastics and a bacterial infection on grass carp, a common freshwater fish. They found that nanoplastic exposure worsened the impact of the infection by increasing oxidative stress, suppressing immune responses, and disrupting the gut microbiome. The study suggests that nanoplastic pollution in waterways could make fish more vulnerable to disease by weakening their natural defenses.
Nanoplastics enhance the intestinal damage and genotoxicity of sulfamethoxazole to medaka juveniles (Oryzias melastigma) in coastal environment
AI summary Read the abstract
Scientists exposed young medaka fish to the antibiotic sulfamethoxazole and polystyrene nanoplastics, both individually and together, to study their combined effects on intestinal health. They found that co-exposure caused more severe gut damage than either pollutant alone, disrupting the gut microbiome and triggering changes in gene expression related to immune defense and DNA repair. The study suggests that nanoplastics may amplify the harmful effects of antibiotics on fish in coastal environments.
Effects of polystyrene nanoplastics on Ctenopharyngodon idella (grass carp) after individual and combined exposure with zinc oxide nanoparticles
AI summary Read the abstract
Researchers studied the individual and combined toxic effects of polystyrene nanoplastics and zinc oxide nanoparticles on grass carp. They found that co-exposure caused more severe oxidative stress, immune suppression, and gill tissue damage than either pollutant alone. The study suggests that interactions between nanoplastics and metal nanoparticles in aquatic environments can produce synergistic toxic effects on freshwater fish.
Effects of chronic co-exposure polystyrene nanoplastics and cadmium on liver function in Prussian carp (Carassius gibelio)
AI summary Read the abstract
Researchers exposed Prussian carp to polystyrene nanoplastics and cadmium, both individually and together, for 21 days and found that the combination caused significantly worse liver damage than either pollutant alone. The nanoplastics enhanced cadmium accumulation in the liver and amplified oxidative stress, tissue damage, and immune gene activation. The findings demonstrate that nanoplastics and heavy metals can have synergistic toxic effects on aquatic organisms.
Ecotoxicological effects of polystyrene nanoplastics on common carp: Insights into blood parameters, DNA damage, and gene expression
AI summary Read the abstract
Exposing common carp to polystyrene nanoplastics caused significant DNA damage in blood and brain cells, along with changes in genes related to immune function and stress response. Higher concentrations led to more severe effects, and the nanoplastics also disrupted liver antioxidant defenses. Since carp are widely consumed fish, these findings raise questions about the safety of fish from nanoplastic-contaminated waters for human consumption.
Research digests by email
When a large batch of papers lands in the Atlas, we read through it and send a short write-up of what stood out.