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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Gut & Microbiome
Marine & Wildlife
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Diet preference of zebrafish (Danio rerio) for bio-based polylactic acid microplastics and induced intestinal damage and microbiota dysbiosis
Journal of Hazardous Materials2022
141 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 60
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
Lei Wang
Lei Wang
Zhenghua Duan,
Zhenghua Duan,
Lei Wang
Haodong Cheng,
Zhenghua Duan,
Huajing Zhang,
Zhenghua Duan,
Zhenghua Duan,
Yudi Wang,
Yudi Wang,
Haodong Cheng,
Huajing Zhang,
Haodong Cheng,
Haodong Cheng,
Lei Wang
Lei Wang
Zhenghua Duan,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Zhenghua Duan,
Xinyue Duan,
Haodong Cheng,
Haodong Cheng,
Xinyue Duan,
Haodong Cheng,
Haodong Cheng,
Yudi Wang,
Haodong Cheng,
Haodong Cheng,
Zhenghua Duan,
Lei Wang
Haodong Cheng,
Haodong Cheng,
Xinyue Duan,
Haodong Cheng,
Lei Wang
Lei Wang
Lei Wang
Zhenghua Duan,
Lei Wang
Lei Wang
Xinyue Duan,
Zhenghua Duan,
Haodong Cheng,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Zhenghua Duan,
Zhenghua Duan,
Zhiyuan Gong,
Yudi Wang,
Yudi Wang,
Yudi Wang,
Yudi Wang,
Xinyue Duan,
Xinyue Duan,
Haihong Zhang,
Xinyue Duan,
Xinyue Duan,
Hongwen Sun,
Lei Wang
Lei Wang
Hongwen Sun,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Yudi Wang,
Lei Wang
Lei Wang
Zhiyuan Gong,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Hongwen Sun,
Hongwen Sun,
Haodong Cheng,
Zhiyuan Gong,
Haodong Cheng,
Yudi Wang,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Huajing Zhang,
Lei Wang
Lei Wang
Huajing Zhang,
Lei Wang
Lei Wang
Lei Wang
Huajing Zhang,
Huajing Zhang,
Lei Wang
Lei Wang
Zhenghua Duan,
Zhenghua Duan,
Hongwen Sun,
Zhenghua Duan,
Lei Wang
Lei Wang
Zhiyuan Gong,
Zhiyuan Gong,
Zhenghua Duan,
Zhenghua Duan,
Zhenghua Duan,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Hongwen Sun,
Hongwen Sun,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Zhiyuan Gong,
Lei Wang
Lei Wang
Zhenghua Duan,
Lei Wang
Lei Wang
Zhenghua Duan,
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Lei Wang
Summary
Researchers found that zebrafish actively preferred to eat bio-based polylactic acid microplastics over conventional petroleum-based polyethylene terephthalate microplastics, accumulating roughly 170 times more of the bio-based particles in their intestines. Both types of microplastics caused intestinal damage and disrupted the gut microbiome, but the higher ingestion rate of bio-based plastics led to greater harm. The study raises important questions about whether biodegradable plastics may actually pose equal or greater risks to aquatic life due to their attractiveness as a food source.
The ingestion of petroleum-based microplastics (MPs) by aquatic animals and their toxicological effects are of wide concern. However, the ecological risks of bio-based MPs to aquatic animals remain largely unknown. In the present study, zebrafish (Danio rerio) were exposed to MPs of polylactic acid (PLA), the most widely used bio-based plastic, and polyethylene terephthalate (PET), a high-production volume petroleum-based plastic. PLA MPs were more actively ingested by fish than PET MPs. The abundance of PLA MPs in fish intestines was approximately 170 times greater than that of PET MPs after one day of exposure. The ingestion of PLA MPs caused gastrointestinal damage in zebrafish. In addition, the ingestion of PLA MPs induced specific changes in the diversity of intestinal microbiota and promoted species closely linked with energy metabolism, cellular processes, and fish diseases. This might have been related to the depolymerization of PLA in the digestive tract, which decreased the intestinal pH and changed the carbon source structure. Overall, bio-based MPs may have different ecological effects on aquatic animals than traditional petroleum-based MPs.