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Polycarbonate nanoplastics and the in vitro assessment of their toxicological impact on liver functionality
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Researchers found that polycarbonate nanoplastics and molecular by-products formed during photodegradation both induce toxicity toward hepatocellular functions in liver cell models, demonstrating dual harmful effects from a single degradation process.
Polycarbonate photodegradation products, namely nanoplastics and molecular by-products, are formed in a single step. Studying their effects in a suitable hepatic model proves that both components induce toxicity toward hepatocellular functions.
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Researchers found that UV-weathered polystyrene micro- and nanoplastics at environmentally relevant concentrations induced hepatotoxicity in human liver cells and caused significant changes in gene expression related to liver disease pathways.
In vitro toxicity of polyethylene terephthalate nanoplastics (PET-NPs) in human hepatocarcinoma (HepG2) cell line
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Exposure of HepG2 human liver cells to PET nanoplastics for 72 hours caused dose-dependent reductions in cell viability, oxidative stress at higher concentrations, and significant DNA damage via comet assay, with an IC50 of 616.7 µg/mL. These in vitro findings indicate that PET nanoplastics — shed from the world's most widely used plastic — have genotoxic and cytotoxic potential in human liver tissue, warranting further investigation of carcinogenic risk at environmentally relevant concentrations.
Hepatotoxic Mechanisms of Micro- and Nanoplastics in Animal Models: A Scoping Review with Human Health Implications
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This scoping review examines hepatotoxic mechanisms of micro- and nanoplastics in animal models, identifying oxidative stress, inflammation, lipid peroxidation, and epigenetic alterations as the primary pathways through which plastic particles damage liver tissue.
Exploring the impact of nanoplastics on human hepatic cells: dynamics of internalization and harmful effects in HuH-7 cells
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Researchers investigated how nanoplastics are internalized by human liver cancer cells (HuH-7) and assessed the cellular damage that follows, characterizing the dynamics of particle uptake and the resulting cytotoxic effects relevant to hepatic health.
Differences in toxicity induced by the various polymer types of nanoplastics on HepG2 cells
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Researchers compared the toxicity of three common nanoplastic types on human liver cells and found that PET (used in bottles) and PVC were significantly more toxic than polystyrene, causing cell death through oxidative stress and a mitochondrial damage pathway. This is important because most toxicity studies have only tested polystyrene, potentially underestimating the health risks of the plastic types people actually encounter most in food and beverage packaging.
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