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Exploring the impact of nanoplastics on human hepatic cells: dynamics of internalization and harmful effects in HuH-7 cells
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Researchers investigated how nanoplastics are internalized by human liver cancer cells (HuH-7) and assessed the cellular damage that follows, characterizing the dynamics of particle uptake and the resulting cytotoxic effects relevant to hepatic health.
The increasing prevalence of micro- and nanoplastics (MNPLs) in the environment necessitates a detailed examination of their potential health impacts and the factors influencing these responses.
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Surface topography of nanoplastics modulates their internalization and toxicity in liver cells
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Researchers found that the surface topography of nanoplastics significantly affects their internalization and toxicity in liver cells, revealing that surface roughness and texture modulate how these particles interact with cellular systems.
Uptake and Effects of Micro‐, Submicro‐ and Nanoplastics Investigated on in vitro Models of the Intestinal Barrier and the Liver
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Researchers investigated the uptake and toxic effects of micro-, submicro-, and nanoplastics using in vitro models of the intestinal barrier and liver to assess how plastic particles of different sizes interact with gastrointestinal and hepatic cells. The study examined cellular internalization, barrier integrity, and metabolic responses to characterize size-dependent toxicity mechanisms.
The size-dependent effects of nanoplastics in mouse primary hepatocytes from cells to molecules
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Researchers studied how different sizes of nanoplastics affect mouse liver cells, finding that particle size significantly influences toxicity. Larger nanoplastics were more harmful at low doses, while smaller particles caused greater damage at high doses by more effectively penetrating cells and disrupting enzyme function. The study suggests that nanoplastic size is a critical factor in determining potential liver health risks.
Nanoplastics as Hepatic Toxicant Vectors: Interactions with Environmental Chemicals, Organelle Dysfunction, and Regulated Cell Death.
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This review summarizes existing research on how tiny nanoplastic particles may affect liver cells. Studies found links between nanoplastic exposure and problems like cell stress, damaged energy-producing structures, and triggered cell death pathways, though results varied depending on the plastic type and test conditions used. The authors note gaps in understanding how these findings relate to real-world health risks.
Effects of polystyrene micro/nanoplastics on liver cells based on particle size, surface functionalization, concentration and exposure period
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Researchers systematically studied the effects of polystyrene micro- and nanoplastics on human liver cells, varying particle size, surface chemistry, concentration, and exposure duration. They found that smaller particles were internalized more readily and that surface functionalization significantly influenced toxicity, with aminated particles causing the most cell damage. The study suggests that particle characteristics beyond just size play an important role in determining how micro- and nanoplastics affect human cells.
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