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Tier 2
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Original research — experimental, observational, or case-control study. Direct primary evidence.
Gut & Microbiome
Human Health Effects
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Exposure to polyethylene microplastics alters immature gut microbiome in an infant in vitro gut model
Journal of Hazardous Materials2022
53 citations
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Citation count from OpenAlex, updated daily. May differ slightly from the publisher's own count.
Score: 55
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0–100 AI score estimating relevance to the microplastics field. Papers below 30 are filtered from public browse.
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
Erwan Engel,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
E Fournier,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Lucie Etienne‐Mesmin,
Mathilde Lévêque,
Mathilde Lévêque,
Jérémy Ratel,
Jérémy Ratel,
Jérémy Ratel,
Sylvain Denis,
Sylvain Denis,
Sylvain Denis,
Sylvain Denis,
Sylvain Denis,
Sylvain Denis,
Sylvain Denis,
Sylvain Denis,
Philippe Ruiz,
Philippe Ruiz,
Muriel Mercier‐Bonin,
Lucie Etienne‐Mesmin,
Valérie Bézirard,
Muriel Mercier‐Bonin,
Valérie Bézirard,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Valérie Bézirard,
Valérie Bézirard,
Lucie Etienne‐Mesmin,
Muriel Mercier‐Bonin,
Valérie Bézirard,
Valérie Bézirard,
Muriel Mercier‐Bonin,
Valérie Bézirard,
Valérie Bézirard,
Muriel Mercier‐Bonin,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
E Fournier,
Jérémy Ratel,
Mathilde Lévêque,
Mathilde Lévêque,
Frédéric Amiard,
Bruno Lamas,
Frédéric Amiard,
Philippe Ruiz,
Frédéric Amiard,
Frédéric Amiard,
Philippe Ruiz,
Frédéric Amiard,
Lucie Etienne‐Mesmin,
Philippe Ruiz,
Carine Mazal,
Muriel Mercier‐Bonin,
Carine Mazal,
Mathilde Lévêque,
Carine Mazal,
Sylvain Denis,
Stéphanie Blanquet‐Diot,
Erwan Engel,
Carine Mazal,
Stéphanie Blanquet‐Diot,
Franck Lagarde
Sylvain Denis,
Muriel Mercier‐Bonin,
Frédéric Amiard,
Frédéric Amiard,
Frédéric Amiard,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Lucie Etienne‐Mesmin,
Mathieu Edely,
Mathieu Edely,
Mathieu Edely,
Stéphanie Blanquet‐Diot,
Mathieu Edely,
Muriel Mercier‐Bonin,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin,
Valérie Bézirard,
Valérie Bézirard,
Valérie Bézirard,
Valérie Bézirard,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Eric Gaultier,
Eric Gaultier,
Lucie Etienne‐Mesmin,
Eric Gaultier,
Eric Gaultier,
Eric Gaultier,
Eric Gaultier,
Muriel Mercier‐Bonin,
Eric Gaultier,
Lucie Etienne‐Mesmin,
Eric Gaultier,
Lucie Etienne‐Mesmin,
Bruno Lamas,
Bruno Lamas,
Bruno Lamas,
Bruno Lamas,
Éric Houdeau,
Lucie Etienne‐Mesmin,
Éric Houdeau,
Éric Houdeau,
Éric Houdeau,
Erwan Engel,
Stéphanie Blanquet‐Diot,
Erwan Engel,
Erwan Engel,
Franck Lagarde
Lucie Etienne‐Mesmin,
Stéphanie Blanquet‐Diot,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Lucie Etienne‐Mesmin,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Stéphanie Blanquet‐Diot,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Muriel Mercier‐Bonin,
Franck Lagarde
Summary
Researchers used an artificial infant gut model to study how chronic exposure to polyethylene microplastics affects the developing intestinal microbiome. They found that microplastics shifted gut microbial composition, increasing the abundance of potentially harmful bacteria such as Enterobacteriaceae while decreasing beneficial butyrate production. The study suggests that microplastic ingestion may disrupt the gut microbiome of infants, though no significant damage to the intestinal barrier was observed.
Infants are characterized by an immaturity of the gut ecosystem and a high exposure to microplastics (MPs) through diet, dust and suckling. However, the bidirectional interactions between MPs and the immature infant intestinal microbiota remain unknown. Our study aims to investigate the impact of chronic exposure to polyethylene (PE) MPs on the gut microbiota and intestinal barrier of infants, using the new Toddler mucosal Artificial Colon coupled with a co-culture of epithelial and mucus-secreting cells. Gut microbiota composition was determined by 16S metabarcoding and microbial activities were evaluated by gas, short chain fatty acid and volatolomics analyses. Gut barrier integrity was assessed via evaluation of intestinal permeability, inflammation and mucus synthesis. Exposure to PE MPs induced gut microbial shifts increasing α-diversity and abundance of potentially harmful pathobionts, such as Dethiosulfovibrionaceae and Enterobacteriaceae. Those changes were associated to butyrate production decrease and major changes in volatile organic compounds profiles. In contrast, no significant impact of PE MPs on the gut barrier, as mediated by microbial metabolites, was reported. For the first time, this study indicates that ingestion of PE MPs can induce perturbations in the gut microbiome of infants. Next step would be to further investigate the potential vector effect of MPs.