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Sub-chronic oral exposure to PET nanoplastics: Histopathological effects on ileum, liver, and kidney
Summary
Researchers conducted a sub-chronic oral exposure study in rats using PET nanoplastics, examining histopathological changes in the ileum and other intestinal tissues. PET nanoplastic exposure caused significant structural damage to the intestinal lining at doses relevant to estimated human dietary exposure.
Polyethylene terephthalate (PET) plastics are widely used synthetic polymers in packaging for water, fruit juices, and soft drinks. During the production and use of these plastics, microplastics (MPs) and nanoplastics (NPs) are releasing, contributing to PET plastics becoming a prevalent nanopollutant, posing significant concerns for both the environment and human health. This study aimed to investigate the effects of orally administered PET nanoplastics on the ileum, liver, and kidney. For this purpose, PET nanoplastics with a diameter of 56 nm were produced using the dilution-precipitation technique and administered to mice orally at the doses of 0, 0.1, and 0.5 mg/day for 28 days. Following sub-chronic exposure of PET-NPs, organ indexes were calculated and histopathological analysis were performed. Our data revealed that sub-chronic exposure to PET-NPs did not significantly affect liver, kidney or ileum indexes compared to the control group (p¿0.05). Histopathological damage caused by PET nanoplastics was significantly higher in all examined tissues compared to that of in the control group (p Also see: https://micro2024.sciencesconf.org/558673/document