Joint analysis of zebrafish gut flora and liver transcriptome by exposure to polystyrene microplastics and cadmium

Integrated analysis of zebrafish gut microbiota and liver transcriptome responses to polystyrene microplastics and cadmium

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Researchers exposed zebrafish to polystyrene microplastics and cadmium, both individually and combined, and found that combined exposure caused more severe disruption to gut bacteria and liver gene expression than either pollutant alone. The study revealed that microplastics decreased beneficial gut bacteria while increasing pathogenic species, and the combined treatment suppressed liver xenobiotic metabolism and antioxidant pathways.

Oxidative damage and intestinal microbial imbalance induced by polystyrene microplastics and cadmium in zebrafish (Danio rerio)

Metabolomic profiling reveals intestinal toxicity in zebrafish upon single and combined exposure to polystyrene microplastics and azithromycin

Multi-omic Approach on the Ecotoxicological Assessment of Microplastics, Antibiotics and Their Co-exposure to Zebrafish

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This PhD thesis investigated co-exposure effects of microplastics and antibiotics on zebrafish using multi-omic approaches, examining transcriptomic, proteomic, and metabolomic responses. Combined exposure produced more complex molecular disruption than either stressor alone, with interactions affecting gut microbiome composition and host metabolic phenotype.