Multi-omic Approach on the Ecotoxicological Assessment of Microplastics, Antibiotics and Their Co-exposure to Zebrafish

Recent advances of microplastics toxicity and fate on zebrafish-a review

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This review synthesizes evidence on how micro- and nanoplastics cause developmental, reproductive, gastrointestinal, and oxidative stress toxicity in zebrafish, positioning the species as a valuable vertebrate model for understanding plastic pollutant effects across trophic levels. Zebrafish research is accelerating mechanistic understanding of how microplastics harm vertebrate biology, providing insights relevant to assessing risks for fish-eating wildlife and humans.

Metabolomic profiling reveals intestinal toxicity in zebrafish upon single and combined exposure to polystyrene microplastics and azithromycin

Bioaccumulation and Toxic Effects of Micro- and Nanoplastics in Zebrafish: A Critical Review

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Researchers comprehensively reviewed micro- and nanoplastic bioaccumulation and toxicity in zebrafish, finding that these particles accumulate in digestive organs, gills, liver, and brain, inducing oxidative stress, developmental delays, neurotoxicity, and transgenerational reproductive impairments that highlight broad ecological risks.

Microplastic Contamination in Aquatic Organisms: An Ecotoxicological Perspective

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"This ecotoxicological review examined how microplastics accumulate in aquatic organisms across multiple trophic levels, documenting impacts on physiology, reproduction, and behavior, as well as the transport of associated chemical contaminants through food webs. Because humans sit at the top of aquatic food chains, the bioaccumulation dynamics described here translate directly into dietary microplastic exposure, making ecotoxicological endpoints in fish and shellfish key indicators of human health risk."

Toxicity and behavioral response of zebrafish exposed to combined microplastic and bisphenol analogues

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Co-exposure of zebrafish larvae to polystyrene microplastics combined with bisphenol A or F increased larval lethality by 7–51% compared to either pollutant alone, while also causing stronger behavioral effects including reduced movement and activity. This synergistic toxicity — not seen in embryos — highlights the danger of treating microplastics and chemical contaminants as independent hazards, since real-world exposures are always mixed.