Metabolomic profiling reveals intestinal toxicity in zebrafish upon single and combined exposure to polystyrene microplastics and azithromycin

Multi-omic Approach on the Ecotoxicological Assessment of Microplastics, Antibiotics and Their Co-exposure to Zebrafish

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This PhD thesis investigated co-exposure effects of microplastics and antibiotics on zebrafish using multi-omic approaches, examining transcriptomic, proteomic, and metabolomic responses. Combined exposure produced more complex molecular disruption than either stressor alone, with interactions affecting gut microbiome composition and host metabolic phenotype.

Oxidative damage and intestinal microbial imbalance induced by polystyrene microplastics and cadmium in zebrafish (Danio rerio)

Toxicity and behavioral response of zebrafish exposed to combined microplastic and bisphenol analogues

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Co-exposure of zebrafish larvae to polystyrene microplastics combined with bisphenol A or F increased larval lethality by 7–51% compared to either pollutant alone, while also causing stronger behavioral effects including reduced movement and activity. This synergistic toxicity — not seen in embryos — highlights the danger of treating microplastics and chemical contaminants as independent hazards, since real-world exposures are always mixed.

Joint effects of micro-sized polystyrene and chlorpyrifos on zebrafish based on multiple endpoints and gut microbial effects

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Researchers found that micro-sized polystyrene particles accumulated in zebrafish gut and liver, causing oxidative stress and gut microbiome disruption, and that co-exposure with chlorpyrifos pesticide amplified toxic effects at the individual level.