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Gut-on-a-Chip Reveals Reduced Nanoplastic-Induced Inflammation Through Enhanced Peristalsis
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A gut-on-a-chip device with integrated sensors showed that nanoplastics caused cell damage, tight junction loss, and inflammatory cytokine peaks (IL-6, TNF-α) within 24 hours, but that increasing mechanical peristaltic strain from 5% to higher levels significantly reduced these inflammatory responses.
Nanoplastics (NPs) pollution threatens human health, particularly the digestive system, by exacerbating intestinal inflammation and increasing the risk of inflammatory bowel disease (IBD). Using a biomimetic gut-on-a-chip (GOC) with integrated sensors, we investigated NPs' effects and explored enhanced peristalsis as a potential intervention. The GOC mimicked intestinal peristalsis via periodic stretching and detected inflammatory cytokines IL-6 and TNF-α over 12 days. NPs caused cell damage, tight junction protein loss, and cytokine peaks at 24 hours. Remarkably, increasing strain from 5% to 6.5% reduced IL-6 and TNF-α secretion by 2.73-fold and 3.34-fold, highlighting peristalsis’ protective role.
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Gut‐on‐a‐Chip Reveals Enhanced Peristalsis Reduces Nanoplastic‐Induced Inflammation
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Researchers built a miniature gut-on-a-chip device that mimics intestinal movement to study how nanoplastics affect the digestive system. They found that nanoplastic exposure caused significant inflammation and cell damage in the simulated gut lining. Notably, increasing the intensity of gut-like contractions substantially reduced the inflammatory response, suggesting that healthy intestinal movement may help protect against nanoplastic-related harm.
Impact of Nanoplastic Particles on Intestinal Epithelium Health Using a Vascularized Gut-on-aChip Model
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Researchers developed a vascularized gut-on-a-chip model to evaluate how nanoplastics affect intestinal health, focusing on bioaccumulation, translocation across epithelial barriers, and immune responses at the gut-blood interface — a more physiologically realistic platform than conventional cell culture approaches.
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Researchers developed a vascularized gut-on-a-chip model to evaluate how nanoplastics affect intestinal health, focusing on bioaccumulation, translocation across epithelial barriers, and immune responses at the gut-blood interface — a more physiologically realistic platform than conventional cell culture approaches.
Impact of Nanoplastic Particles on Intestinal Epithelium Health Using a Vascularized Gut-on-aChip Model
AI summary Read the abstract
Researchers developed a vascularized gut-on-a-chip model to evaluate how nanoplastics affect intestinal health, focusing on bioaccumulation, translocation across epithelial barriers, and immune responses at the gut-blood interface — a more physiologically realistic platform than conventional cell culture approaches.
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Researchers developed a vascularized gut-on-a-chip model to assess how nanoplastic particles affect the intestinal barrier, focusing on bioaccumulation, translocation across epithelial and endothelial layers, and disruption of mucus and immune interfaces under physiologically relevant conditions.
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