Su1286: ELEVATED TEMPERATURE EXACERBATES POLYSTYRENE MICROPLASTIC-INDUCED INTESTINAL BARRIER DYSFUNCTION, INFLAMMATION, AND MICROBIOME ALTERATIONS

Impact of Microplastics on the Severity of Intestinal Inflammation in Mice

Impact of Micro-nanoplastics on Gut and Immune Function

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This review examined how micro- and nanoplastics disrupt gut microbiota and immune function across aquatic and terrestrial vertebrates, with implications for human health. Because the gut microbiome governs immune regulation and metabolic health, microplastic-induced dysbiosis represents a plausible mechanism by which plastic ingestion could drive systemic inflammation and disease beyond the GI tract.

Polydisperse polystyrene microplastics exacerbate colitis through gut microbiota-butyrate-PPARγ axis disruption in mice

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This study demonstrates that exposure to polydisperse polystyrene microplastics worsens colitis symptoms in experimental animal models. The microplastics appear to aggravate intestinal inflammation by disrupting gut barrier function and amplifying immune responses. These results raise concern about microplastic exposure as a potential risk factor for inflammatory bowel conditions.

Impact of microplastics on the intestinal microbiota: A systematic review of preclinical evidence

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Across 28 preclinical studies, microplastics triggered intestinal dysbiosis characterized by increased Firmicutes and Proteobacteria and decreased Bacteroidetes, while increasing gut permeability and elevating pro-inflammatory cytokines including IL-1β, TNF-α, and IL-6.

Polystyrene microplastics trigger intestinal inflammation through CXCL11-mediated T-cell recruitment

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Scientists found that microplastics, tiny plastic particles now found in water, food, and even our bodies, can trigger significant gut inflammation in fish by activating a specific immune signaling pathway that recruits inflammatory cells into intestinal tissue. While this study was done in zebrafish, not humans, it reveals a detailed biological mechanism for how these ubiquitous plastic particles might damage gut health, raising important questions about similar effects in people given how widely microplastics have infiltrated our environment and food supply.